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    Diastereoselective method of preparing olefins by means of the horner-wadsworthemmons reaction, comprising the addition of a tris-(polyoxaalkyl)-amine sequestering agent
    1.
    发明申请
    Diastereoselective method of preparing olefins by means of the horner-wadsworthemmons reaction, comprising the addition of a tris-(polyoxaalkyl)-amine sequestering agent 审中-公开
    通过天然气流动反应制备烯烃的非对映选择性方法，包括加入三 - （聚氧杂烷基） - 胺螯合剂

    公开(公告)号：US20060100456A1

    公开(公告)日：2006-05-11

    申请号：US10528715

    申请日：2003-09-22

    申请人： Fracois Touchard ,  Olivier Buisine ,  Frederic Leguyader ,  Thierry Schlama ,  Franco Manfre

    发明人： Fracois Touchard ,  Olivier Buisine ,  Frederic Leguyader ,  Thierry Schlama ,  Franco Manfre

    IPC分类号： C07F9/22 ,  C07C315/04 ,  C07C253/30 ,  C07C231/12

    CPC分类号： C07D333/24 ,  C07B2200/09 ,  C07C67/343 ,  C07C2601/14 ,  C07D213/48 ,  C07C69/65 ,  C07C69/734 ,  C07C69/618 ,  C07C69/608

    摘要： The invention relates to a process for the diastereoselective preparation of olefins via the Homer-Wadsworth-Emmons reaction, which consists in reacting at low temperature a phosphonate with a carbonyl derivative in the presence of a base in a suitable solvent, characterized in that a tris(polyoxaalkyl)amine sequestering reagent of formula (I): N—[CHR1—CHR2—O—(CHR3—CHR4—O)n—R5]3 (I), wherein: n is an integer between 0 and 10; R1, R2, R3 and R4 may be identical or different, and represent a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms; R5 represents a hydrogen atom, an alkyl or cycloalkyl radical containing up to 12 carbon atoms, a phenyl radical or a radical of formula —CμH2μ-Φ, or CmH2m+1-Φ-, with m being an integer between 1 and 12 and Φ being a phenyl radical; is added in an amount that is sufficient to increase the diastereoselectivity of the olefin.

    摘要翻译： 本发明涉及通过Homer-Wadsworth-Emmons反应非对映选择性制备烯烃的方法，该方法在低温下使膦酸酯与羰基衍生物在碱的存在下在合适的溶剂中反应，其特征在于三 （I）的（多氧烷基）胺螯合试剂：N- [CHR 1 -CH 2，-SO 2 -O-（CHR 3 - （I）其中：n是介于0和...之间的整数，其中，n是0和...之间的整数。 10; R 1，R 2，R 3和R 4可以相同或不同，并且表示氢原子 或含有1至4个碳原子的烷基; R 5表示氢原子，含有至多12个碳原子的烷基或环烷基，苯基或式-CmuH 2 mu-Phi的基团或C m H 2m + 1 -hi-，m是1和12之间的整数，Phi是苯基; 以足以增加烯烃的非对映选择性的量加入。

    Method of preparing an acylimidazolium-type reagent
    2.
    发明申请
    Method of preparing an acylimidazolium-type reagent 审中-公开
    制备酰基咪唑型试剂的方法

    公开(公告)号：US20060149051A1

    公开(公告)日：2006-07-06

    申请号：US10542249

    申请日：2004-01-14

    申请人： Thierry Schlama ,  Franco Manfre

    发明人： Thierry Schlama ,  Franco Manfre

    IPC分类号： C07H21/04 ,  C07D233/91

    CPC分类号： C07D233/54

    摘要： The invention relates to a method of preparing an acylimidazolium-type reagent. More specifically, the invention relates to a salt of N-(benzyloxycarbonyl)-N′-methylimidazolium. The inventive method of preparing an acylimidazolium-type reagent is characterised in that it is obtained by: (i) reacting a reagent comprising a —COX group having formula (II) and an imidazole reagent having formula (III); and (ii) subsequently, adding a strong acid HY to the product thus obtained, said acid having a pKa of less than 1, which produces the desired reagent.

    摘要翻译： 本发明涉及一种制备酰基咪唑型试剂的方法。 更具体地说，本发明涉及N-（苄氧基羰基）-N'-甲基咪唑鎓盐。 制备酰基咪唑型试剂的本发明方法的特征在于：（i）使包含式（II）的-COX基团和具有式（III）的咪唑试剂的试剂反应; 和（ii）随后，向由此获得的产物中加入强酸HY，所述酸的pKa小于1，产生所需试剂。

    Process for preparing a polyaromatic compound
    3.
    发明授权
    Process for preparing a polyaromatic compound 失效
    制备多芳族化合物的方法

    公开(公告)号：US06800784B1

    公开(公告)日：2004-10-05

    申请号：US10130656

    申请日：2002-09-03

    申请人： Thierry Schlama ,  Jean-Christophe Bigouraux

    发明人： Thierry Schlama ,  Jean-Christophe Bigouraux

    IPC分类号： C07C21145

    CPC分类号： C07C211/45 ,  C07C209/68

    摘要： The present invention concerns a process for preparing a polyaromatic compound comprising a concatenation of two aromatic cycles and carrying at least one amino group on one of the aromatic cycles. The process of the invention is characterized in that it consists of reacting an aromatic compound carrying at least one amino group and a leaving group with an arylboronic acid in an aqueous medium and in the presence of a palladium catalyst.

    摘要翻译： 本发明涉及一种制备多芳族化合物的方法，该方法包括两个芳环的连接并在一个芳环上带有至少一个氨基。 本发明的方法的特征在于它包括使含有至少一个氨基的芳族化合物和离去基团与芳基硼酸在水性介质中和钯催化剂存在下反应。

    Method of preparation of an alkyne with an optically active hydroxyl group in the beta or gamma position of a triple bond and intermediates obtained
    7.
    发明申请
    Method of preparation of an alkyne with an optically active hydroxyl group in the beta or gamma position of a triple bond and intermediates obtained 审中-公开
    在三键的β或γ位置制备具有光学活性羟基的炔烃的方法和获得的中间体

    公开(公告)号：US20070004942A1

    公开(公告)日：2007-01-04

    申请号：US11476196

    申请日：2006-06-28

    申请人： Laurent Garel ,  Thierry Schlama

    发明人： Laurent Garel ,  Thierry Schlama

    IPC分类号： C07C33/04 ,  C07F7/02

    CPC分类号： C07C29/36 ,  C07B2200/07 ,  C07C33/042 ,  C07C31/36

    摘要： The present invention relates to a method of preparation of an alkyne with an optically active hydroxyl group in the β or γ position of a triple bond and intermediates obtained. The method of the invention for preparation of an alkyne with an optically active hydroxyl group in the β position of a triple bond is characterized in that it comprises the reaction, in the presence of a Lewis acid: of a compound of formula (IV): in which: R is a linear or branched alkyl group having from 1 to 6 carbon atoms. and of a compound of formula (V): R′—C≡C-M   (V) in which: R′ represents a hydrogen atom, a linear or branched alkyl group having from 1 to 8 carbon atoms, preferably a methyl group or a trialkylsilyl group. M represents a metal, preferably a metal of group (Ia) of the periodic table, preferably lithium. Another object of the invention comprises the production of an alkyne with an optically active hydroxyl group in the γ position of a triple bond by isomerization of an alkyne with an optically active hydroxyl group in the β position previously obtained.

    摘要翻译： 本发明涉及一种在三键的β或γ位具有光学活性羟基的炔烃的制备方法和中间体。 在三键的β位上制备具有光学活性羟基的炔烃的本发明的方法的特征在于其包含在路易斯酸存在下的反应：式（Ⅳ）化合物： 其中：R为具有1至6个碳原子的直链或支链烷基。 和式（V）化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> R'-C≡CM（V）<？in-line-formula description = “直链式”末端=“尾”→其中：R'表示氢原子，具有1至8个碳原子的直链或支链烷基，优选甲基或三烷基甲硅烷基。 M表示金属，优选元素周期表（Ia）族的金属，优选锂。 本发明的另一个目的是通过在先前获得的β位上通过异构化具有光学活性羟基的炔异构化在三键的γ位置制备具有光学活性羟基的炔。

    Method for preparing aromatic diphenyl thioethers
    8.
    发明授权
    Method for preparing aromatic diphenyl thioethers 失效
    制备芳香族二苯硫醚的方法

    公开(公告)号：US06596905B1

    公开(公告)日：2003-07-22

    申请号：US09868823

    申请日：2001-08-27

    申请人： Thierry Schlama ,  Jean-Christophe Bigouraux

    发明人： Thierry Schlama ,  Jean-Christophe Bigouraux

    IPC分类号： C07C31900

    CPC分类号： C07C319/14 ,  C07C323/29

    摘要： The invention concerns a method for preparing aromatic diphenyl thioethers. More particularly the invention concerns the preparation of 4-chloro-4′-thiomethyldiphenylether. The inventive method for preparing an aromatic diphenyl thioether is characterised in that it consists in reacting in an aqueous medium a diazonium salt of an aromatic diphenyl compound with a disulphide sulphur compound, in the presence of an efficient amount of a coupling catalyst.

    摘要翻译： 本发明涉及一种制备芳族二苯硫醚的方法。 更具体地，本发明涉及4-氯-4'-硫代甲基二苯醚的制备。 本发明的芳族二苯基硫醚的制备方法的特征在于，在有效量的偶联催化剂存在下，其在水性介质中使芳族二苯基化合物的重氮盐与二硫化物硫化合物反应。