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公开(公告)号：US20120142045A1
公开(公告)日：2012-06-07
申请号：US13376057
申请日：2010-06-04
申请人： Francois Ozanam , Larbi Touahir , Elisabeth Galopin , Rabah Boukherroub , Jean-Noel Chazalviel , Anne Chantal Gouget , Sabine Szunerits
发明人： Francois Ozanam , Larbi Touahir , Elisabeth Galopin , Rabah Boukherroub , Jean-Noel Chazalviel , Anne Chantal Gouget , Sabine Szunerits
CPC分类号： G01N21/6428 , G01N21/553 , G01N21/648
摘要： A method of detecting substances or reactions of substances in a sample, comprising: (i) providing a layer (CS) based on hydrogenated or unhydrogenated amorphous silicon with attached probes, (ii) bringing the layer (CS) in contact with the sample that may contain the substances that bind specifically to or reacts specifically with the probes, under appropriate conditions for the substances to bind to or react with the probes; (iii) optionally removing non-specifically bound or non-specifically reactive substances; and (iv) detecting the presence or amount of the specifically bound or reactive substances in the sample by surface plasmon resonance (SPR) and/or fluorescence, is described.
摘要翻译： 一种检测样品中物质或物质反应的方法，包括：（i）提供基于氢化或非氢化非晶硅的附着探针的层（CS），（ii）使层（CS）与样品接触 可能含有与探针结合或与探针结合或反应的适当条件下特异性结合或与探针特异性结合的物质; （iii）任选地除去非特异性结合或非特异性反应物质; 和（iv）通过表面等离子体共振（SPR）和/或荧光来检测样品中特异性结合或反应物质的存在或量。
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2.发明授权System and method of multitechnique imaging for the chemical biological or biochemical analysis of a sample 有权用于化学生物或生化分析样品的多特征成像系统和方法公开(公告)号：US09476827B2
公开(公告)日：2016-10-25
申请号：US13991798
申请日：2011-12-07
申请人： François Ozanam , Jean-Noël Chazalviel , Rabah Boukherroub , Elisabeth Anne-Gabrielle Galopin , Anne Chantal Gouget-Laemmel , Sabine Szunerits , Larbi Touahir
发明人： François Ozanam , Jean-Noël Chazalviel , Rabah Boukherroub , Elisabeth Anne-Gabrielle Galopin , Anne Chantal Gouget-Laemmel , Sabine Szunerits , Larbi Touahir
CPC分类号： G01N21/27 , G01N21/554 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/6463 , G01N2021/6471 , G01N2021/6493 , G02B21/082 , G02B21/16
摘要： The invention substantially relates to an imaging system for the chemical, biological or biochemical analysis of a sample (10), comprising a device (40) for holding the sample (10), a device (20) for optical detection, a lighting device (30), liable to emit a monochromatic light beam, and a wide aperture objective (f1), It is substantially characterized in that the objective (f1) is configured for, downstream of the sample (10): focusing the excitation light beam reflected at a point (C) located in the focal plane (FF) of said objective (f1), and transforming the retransmitted or scattered light beam into a quasi-parallel beam, and in that the system further comprises a device (70) for selectively blocking the collected light beam by said objective (f1).
摘要翻译： 并且所述系统还包括用于通过所述物镜（f1）选择性地阻挡所收集的光束的装置（70）。
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公开(公告)号：US08279444B2
公开(公告)日：2012-10-02
申请号：US11992808
申请日：2006-09-27
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , C03C17/3615 , C03C17/3639 , C03C17/3649 , C03C2217/42 , C23C16/0281 , C23C16/401 , C23C16/56 , G01N21/554 , G01N33/54373 , Y10T428/31663
摘要： The Invention relates to a method for producing a solid support coated by a metal Layer to which an SiOx layer provided with a uniform and stable thickness is applied, wherein said solid support makes it possible to determine the pretense of a compound on the surface thereof by means of Surface Plasmon Resonance (≦SPR ≧).
摘要翻译： 本发明涉及一种由金属层涂覆的固体载体的制造方法，其中施加均匀且稳定的厚度的SiO x层，其中所述固体支持体可以通过以下方式确定化合物的表面上的化学物质： 表面等离子体共振的手段（＆nlE; SPR≧）。
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4.发明申请SOLID SUPPORT COATED WITH AT LEAST ONE METAL FILM AND WITH AT LEAST ONE TRANSPARENT CONDUCTIVE OXIDE LAYER FOR DETECTION BY SPR AND/OR BY AN ELECTROCHEMICAL METHOD 审中-公开用最少的一个金属膜和至少一个透明导电氧化物层的固体支持，用于通过SPR和/或通过电化学方法检测公开(公告)号：US20100311103A1
公开(公告)日：2010-12-09
申请号：US12735041
申请日：2008-12-11
IPC分类号： G01N27/26 , B32B9/00 , B32B15/04 , C23C14/34 , G01N33/44 , G01N33/00 , G01N33/68 , G01N33/92 , G01N33/84 , G01N33/48 , C12Q1/02 , C12M1/34 , G01N21/55
CPC分类号： C23C14/086 , C23C14/025 , G01N21/553 , G01N21/554 , G01N33/553 , Y10T428/265 , Y10T436/143333 , Y10T436/23
摘要： One subject of the present invention is a transparent solid support coated with at least one layer of metal and with at least one layer of transparent conductive oxide (TCO), especially tin-doped indium oxide (ITO) in order to form a solid support that can be used at the same time or independently for detection by SPR and by an electrochemical method. The invention comprises a process for producing such supports, especially by cathode sputtering using a device comprising a radiofrequency (RF) generator, this device also being included in the invention. Another subject of the invention is a kit and a method for detection or identification of an organic or mineral compound by surface plasmon resonance (SPR) and/or electrochemical plasmon resonance comprising or using such supports.
摘要翻译： 本发明的一个主题是涂覆有至少一层金属和至少一层透明导电氧化物（TCO），特别是锡掺杂的氧化铟（ITO）的透明固体载体，以形成固体支持物 可以同时使用或独立使用，以便通过SPR和电化学方法进行检测。 本发明包括一种用于生产这种载体的方法，特别是通过使用包括射频（RF）发生器的装置的阴极溅射），该装置也包括在本发明中。 本发明的另一主题是用于通过表面等离子体共振（SPR）和/或包含或使用这种载体的电化学等离子体共振来检测或鉴定有机或无机化合物的试剂盒和方法。
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公开(公告)号：US20100149540A1
公开(公告)日：2010-06-17
申请号：US11992808
申请日：2006-09-27
IPC分类号： G01N21/55 , C23C16/513 , B32B9/00
CPC分类号： G01N21/553 , C03C17/3615 , C03C17/3639 , C03C17/3649 , C03C2217/42 , C23C16/0281 , C23C16/401 , C23C16/56 , G01N21/554 , G01N33/54373 , Y10T428/31663
摘要： The Invention relates to a method for producing a solid support coated by a metal Layer to which an SiOx layer provided with a uniform and stable thickness is applied, wherein said solid support makes it possible to determine the pretense of a compound on the surface thereof by means of Surface Plasmon Resonance (≦SPR ≧).
摘要翻译： 本发明涉及一种由金属层涂覆的固体载体的制造方法，其中施加均匀且稳定的厚度的SiO x层，其中所述固体支持体可以通过以下方式确定化合物的表面上的化学物质： 表面等离子体共振的手段（＆nlE; SPR≧）。
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公开(公告)号：US06814849B2
公开(公告)日：2004-11-09
申请号：US10012943
申请日：2001-12-10
IPC分类号： C25D712
CPC分类号： C25D11/32
摘要： A porous silicon structure is stabilized by anodically oxidizing the structure and then subjecting it to chemical functionalization to protect non-oxidized surface regions, preferably in the presence of 1-decene under thermal conditions. This process creates a protective organic monolayer on the surface of the structure, rendering it highly stable.
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公开(公告)号：US07332441B2
公开(公告)日：2008-02-19
申请号：US10830035
申请日：2004-04-23
IPC分类号： H01L21/302 , H01L21/461
CPC分类号： B82Y30/00 , B05D1/185 , B05D1/60 , B82Y40/00 , H01L21/306 , Y10S436/805 , Y10S436/823
摘要： A method is disclosed for stabilizing porous silicon. A porous silicon structure having a surface terminated with hydrogen atoms is subjected to organic thermal processing to substitute the hydrogen atoms with a protective organic layer. The resulting structures are found to have unprecedented stability.
摘要翻译： 公开了一种稳定多孔硅的方法。 将具有用氢原子封端的表面的多孔硅结构进行有机热处理以用保护性有机层代替氢原子。 发现所得到的结构具有前所未有的稳定性。
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公开(公告)号：US06677163B1
公开(公告)日：2004-01-13
申请号：US09713300
申请日：2000-11-16
IPC分类号： G01N33552
CPC分类号： C07H15/26 , G01N33/54353 , G01N33/552 , Y10S436/823
摘要： Provided is a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a bio-molecule, to form a covalently attached layer of bio-molecule on the silicon surface.
摘要翻译： 提供了在温和条件下用有机分子改性硅的方法。 如果连接的分子是双功能的，则其可以随后与生物分子反应，以在硅表面上形成共价连接的生物分子层。
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公开(公告)号：US07119361B2
公开(公告)日：2006-10-10
申请号：US10972550
申请日：2004-10-25
IPC分类号： H01L29/08
CPC分类号： C25D11/32
摘要： A porous silicon structure is stabilized by anodically oxidizing the structure and then subjecting it to chemical functionalization to protect non-oxidized surface regions, preferably in the presence of 1-decene under thermal conditions. This process creates a protective organic monolayer on the surface of the structure, rendering it highly stable.
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公开(公告)号：US20050085001A1
公开(公告)日：2005-04-21
申请号：US10972550
申请日：2004-10-25
IPC分类号： C25D11/32 , H01L21/00 , H01L21/31 , H01L21/469
CPC分类号： C25D11/32
摘要： A porous silicon structure is stabilized by anodically oxidizing the structure and then subjecting it to chemical functionalization to protect non-oxidized surface regions, preferably in the presence of 1-decene under thermal conditions. This process creates a protective organic monolayer on the surface of the structure, rendering it highly stable.
摘要翻译： 多孔硅结构通过阳极氧化该结构而稳定化，然后进行化学官能化以保护未氧化的表面区域，优选在1-癸烯存在下在热条件下进行。 该方法在结构表面上产生保护性有机单层，使其高度稳定。
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