公开(公告)号：US20140039210A1

公开(公告)日：2014-02-06

申请号：US14000067

申请日：2011-12-01

申请人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Poetter ,  Anja Schubert ,  Jan Christoph ,  Thomas Tacke ,  Harald Haeger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

发明人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Poetter ,  Anja Schubert ,  Jan Christoph ,  Thomas Tacke ,  Harald Haeger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

IPC分类号： C07C67/62

CPC分类号： C07C67/62 ,  B01D11/0492 ,  B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F2001/425 ,  C02F2101/34 ,  C07C227/40 ,  C07C229/08

摘要： The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution.

摘要翻译： 本发明涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法。 所述方法包括以下步骤a）含有有机化合物的水溶液和含有具有一个或多个负电荷和负总电荷的疏水液体阳离子交换剂的疏水性有机溶液，b）水溶液和 使有机溶液彼此接触并且c）将有机溶液与水溶液分离。

公开(公告)号：US09315443B2

公开(公告)日：2016-04-19

申请号：US14000067

申请日：2011-12-01

申请人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Poetter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Haeger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

发明人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Poetter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Haeger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

IPC分类号： C07C227/00 ,  C07C67/62 ,  B01D11/04 ,  B01J39/04 ,  B01J39/16 ,  C07C227/40 ,  C07C229/08 ,  C02F1/26 ,  C02F1/42 ,  C02F101/34

CPC分类号： C07C67/62 ,  B01D11/0492 ,  B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F2001/425 ,  C02F2101/34 ,  C07C227/40 ,  C07C229/08

摘要： The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution.

摘要翻译： 本发明涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法。 所述方法包括以下步骤a）含有有机化合物的水溶液和含有具有一个或多个负电荷和负总电荷的疏水液体阳离子交换剂的疏水性有机溶液，b）水溶液和 使有机溶液彼此接触并且c）将有机溶液与水溶液分离。

公开(公告)号：US20140054224A1

公开(公告)日：2014-02-27

申请号：US14000028

申请日：2011-12-01

申请人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Pötter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Häger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

发明人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Pötter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Häger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

IPC分类号： B01J39/16 ,  B01J39/04

CPC分类号： C07C67/62 ,  B01D11/0492 ,  B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F2001/425 ,  C02F2101/34 ,  C07C227/40 ,  C07C229/08

摘要： The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution.

摘要翻译： 本申请涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法，包括以下步骤：a）提供包含有机化合物的水溶液和包含液体阳离子交换剂的疏水性有机溶液， 其中液体阳离子交换剂是疏水性的，并且其中液体阳离子交换剂具有一个或多个负电荷和总负电荷，b）使该水溶液和有机溶液接触，和c）从该水溶液中分离有机溶液。

公开(公告)号：US10071951B2

公开(公告)日：2018-09-11

申请号：US14000028

申请日：2011-12-01

申请人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Pötter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Häger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

发明人： Frank Erhardt ,  Thomas Haas ,  Martin Roos ,  Daniel Demicoli ,  Markus Pötter ,  Anja Schubert ,  Jan Christoph Pfeffer ,  Thomas Tacke ,  Harald Häger ,  Andreas Pfennig ,  Marie-Dominique Przybylski-Freund

IPC分类号： B01D11/00 ,  B01J39/04 ,  C07C67/62 ,  B01D11/04 ,  B01J39/16 ,  C07C227/40 ,  C07C229/08 ,  C02F1/26 ,  C02F1/42 ,  C02F101/34

CPC分类号： C07C67/62 ,  B01D11/0492 ,  B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F2001/425 ,  C02F2101/34 ,  C07C227/40 ,  C07C229/08

摘要： The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution.

公开(公告)号：US09919303B2

公开(公告)日：2018-03-20

申请号：US14419580

申请日：2013-07-24

申请人： Frank Erhardt ,  Lukas Falke ,  Ralf Kelle ,  Harald Haeger ,  Thomas Haas ,  Hans-Georg Hennemann ,  Oliver Thum ,  Martin Roos ,  Markus Poetter

发明人： Frank Erhardt ,  Lukas Falke ,  Ralf Kelle ,  Harald Haeger ,  Thomas Haas ,  Hans-Georg Hennemann ,  Oliver Thum ,  Martin Roos ,  Markus Poetter

IPC分类号： B01J39/04 ,  C07C209/90 ,  B01J39/16 ,  C02F1/42 ,  C02F1/26 ,  C07C227/40 ,  C07C209/84 ,  C02F101/30 ,  C02F101/38 ,  C02F103/36

CPC分类号： B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F1/42 ,  C02F2001/425 ,  C02F2101/30 ,  C02F2101/38 ,  C02F2103/36 ,  C07C209/84 ,  C07C209/90 ,  C07C227/40 ,  C07C2601/14

摘要： The present invention relates to a method for removing an organic compound from an aqueous solution, comprising the steps of providing the aqueous solution which contains the organic compound, and a hydrophobic organic solution, where the latter comprises a liquid hydrophobic cation exchanger, contacting the aqueous solution and the hydrophobic organic solution, and separating off the hydrophobic organic solution from the aqueous solution, wherein the liquid hydrophobic cation exchanger is a saturated alkanoic acid having at least one alkyl substituent, where the organic compound is an organic compound having at least one positive charge and a neutral or positive total charge.

公开(公告)号：US20150209775A1

公开(公告)日：2015-07-30

申请号：US14419580

申请日：2013-07-24

申请人： Frank Erhardt ,  Lukas Falke ,  Ralf Kelle ,  Harald Haeger ,  Thomas Haas ,  Hans-Georg Hennemann ,  Oliver Thum ,  Martin Roos ,  Markus Poetter

发明人： Frank Erhardt ,  Lukas Falke ,  Ralf Kelle ,  Harald Haeger ,  Thomas Haas ,  Hans-Georg Hennemann ,  Oliver Thum ,  Martin Roos ,  Markus Poetter

IPC分类号： B01J39/04 ,  B01J39/16 ,  C07C209/90

CPC分类号： B01J39/04 ,  B01J39/16 ,  C02F1/26 ,  C02F1/42 ,  C02F2001/425 ,  C02F2101/30 ,  C02F2101/38 ,  C02F2103/36 ,  C07C209/84 ,  C07C209/90 ,  C07C227/40 ,  C07C2601/14

摘要： The present invention relates to a method for removing an organic compound from an aqueous solution, comprising the steps of providing the aqueous solution which contains the organic compound, and a hydrophobic organic solution, where the latter comprises a liquid hydrophobic cation exchanger, contacting the aqueous solution and the hydrophobic organic solution, and separating off the hydrophobic organic solution from the aqueous solution, wherein the liquid hydrophobic cation exchanger is a saturated alkanoic acid having at least one alkyl substituent, where the organic compound is an organic compound having at least one positive charge and a neutral or positive total charge.

摘要翻译： 本发明涉及一种从水溶液中除去有机化合物的方法，包括提供含有有机化合物的水溶液和疏水性有机溶液的步骤，其中后者包括液体疏水性阳离子交换剂， 溶液和疏水性有机溶液，并从水溶液中分离疏水性有机溶液，其中液体疏水性阳离子交换剂是具有至少一个烷基取代基的饱和链烷酸，其中有机化合物是具有至少一个阳性的有机化合物 充电和中性或正电荷。

公开(公告)号：US20130052700A1

公开(公告)日：2013-02-28

申请号：US13642412

申请日：2011-03-15

申请人： Markus Poetter ,  Andreas Schmid ,  Bruno Buehler ,  Hans-Georg Hennemann ,  Mattijs Kamiel Julsing ,  Steffen Schaffer ,  Thomas Haas ,  Manfred Schrewe ,  Sjef Cornelissen ,  Martin Roos ,  Harald Haeger

发明人： Markus Poetter ,  Andreas Schmid ,  Bruno Buehler ,  Hans-Georg Hennemann ,  Mattijs Kamiel Julsing ,  Steffen Schaffer ,  Thomas Haas ,  Manfred Schrewe ,  Sjef Cornelissen ,  Martin Roos ,  Harald Haeger

IPC分类号： C12P7/62 ,  C12P7/26 ,  C12P7/24 ,  C12P7/04 ,  C12P13/00 ,  C12P7/64 ,  C12N1/21 ,  C12N1/13 ,  C12P7/40 ,  C12P7/02

CPC分类号： C07K14/21 ,  C12P7/02 ,  C12P7/24 ,  C12P7/42 ,  C12P7/62 ,  C12P7/6436 ,  C12Y114/15003

摘要： The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.

摘要翻译： 本发明提供了借助于alkL基因产物和在该方法中使用的微生物来氧化有机化合物的生物催化方法。

公开(公告)号：US20140256904A1

公开(公告)日：2014-09-11

申请号：US14238591

申请日：2012-08-15

申请人： Steffen Schaffer ,  Nicole Decker ,  Jasmin Gielen ,  Harald Haeger ,  Thomas Haas ,  Markus Poetter ,  Hans-Georg Hennemann ,  Mirja Wessel ,  Michael Volland

发明人： Steffen Schaffer ,  Nicole Decker ,  Jasmin Gielen ,  Harald Haeger ,  Thomas Haas ,  Markus Poetter ,  Hans-Georg Hennemann ,  Mirja Wessel ,  Michael Volland

IPC分类号： C12P13/00 ,  C12P13/02 ,  C08G69/08 ,  C12P7/64

CPC分类号： C12P13/02 ,  C08G69/08 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0014 ,  C12N9/0077 ,  C12N9/1029 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P7/40 ,  C12P7/42 ,  C12P7/6409 ,  C12P7/6436 ,  C12P13/005 ,  Y02P20/52

摘要： The subject of the invention is a biotechnological process for the production of ω-functionalized carboxylic acids and of ω-functionalized carboxylate esters from simple carbon sources.

摘要翻译： 本发明的主题是用于从简单碳源生产ω官能化羧酸和ω-官能化羧酸酯的生物技术方法。

公开(公告)号：US20140186905A1

公开(公告)日：2014-07-03

申请号：US14238576

申请日：2012-08-15

申请人： Steffen Schaffer ,  Jasmin Gielen ,  Nicole Decker ,  Nicole Kirchner ,  Thomas Haas ,  Markus Poetter ,  Harald Haeger

发明人： Steffen Schaffer ,  Jasmin Gielen ,  Nicole Decker ,  Nicole Kirchner ,  Thomas Haas ,  Markus Poetter ,  Harald Haeger

IPC分类号： C12P7/64 ,  C12P5/02 ,  C12P13/00

CPC分类号： C12P7/649 ,  C07K14/21 ,  C12P5/026 ,  C12P7/62 ,  C12P7/64 ,  C12P7/6409 ,  C12P13/001 ,  Y02E50/343 ,  Y02T50/678

摘要： Subject matter of the invention is a biotechnological process for the production of organic compounds with the aid of at least one alkL gene product.

摘要翻译： 本发明的主题是借助至少一种alkL基因产物生产有机化合物的生物技术方法。

公开(公告)号：US20130164797A1

公开(公告)日：2013-06-27

申请号：US13721481

申请日：2012-12-20

申请人： Jasmin GIELEN ,  Thomas Haas ,  Hans-Georg Hennemann ,  Steffen Schaffer ,  Mirja Wessel ,  Katharina Berse ,  Marion Schiebelhut ,  Sabine Hafkemeyer ,  Markus Poetter ,  Frank Erhardt

发明人： Jasmin GIELEN ,  Thomas Haas ,  Hans-Georg Hennemann ,  Steffen Schaffer ,  Mirja Wessel ,  Katharina Berse ,  Marion Schiebelhut ,  Sabine Hafkemeyer ,  Markus Poetter ,  Frank Erhardt

IPC分类号： C12P7/64

CPC分类号： C12P7/6436 ,  C12N9/001 ,  C12P13/04 ,  C12Y103/99003

摘要： A process for the improved separation of a hydrophobic organic solution from an aqueous culture medium is provided. The process includes preparing an aqueous culture medium of a metabolically active cell having a decreased activity; contacting of the aqueous culture medium with a hydrophobic organic solution comprising a substrate for biotransformation; conducting a biotransformation of the substrate; and separating the hydrophobic organic solution comprising a biotransformed substrate from the aqueous culture medium. The decreased activity of the metabolically active cell is in comparison to a wild-type of the active cell and the decreased activity is of at least of one enzyme that catalyses one reaction of β-oxidation of fatty acids. The invention further provides a metabolically active cell that has a decreased activity, compared to its wild-type, of an enzyme that catalyses one of the reactions of the β-oxidation of fatty acids, including an enzyme selected from FadA, FadB, FadD, FadL and FadE as well as variants thereof.

摘要翻译： 提供了一种从水性培养基中改进疏水性有机溶液分离的方法。 该方法包括制备活性降低的代谢活性细胞的水性培养基; 使含水培养基与包含用于生物转化的底物的疏水性有机溶液接触; 进行基底的生物转化; 并从含水培养基中分离包含生物转化底物的疏水性有机溶液。 代谢活性细胞的活性降低与野生型活性细胞相比，活性降低至少是一种催化脂肪酸β-氧化反应的一种酶。 本发明还提供了一种代谢活性细胞，其与野生型相比具有降低的活性，所述活性细胞能催化脂肪酸的β-氧化反应之一，包括选自FadA，FadB，FadD， FadL和FadE及其变体。