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49 条记录 (耗时 0.036 秒)

    Stimulus-inducible protein kinase complex and methods of use therefor
    2.
    发明授权
    Stimulus-inducible protein kinase complex and methods of use therefor 失效
    刺激诱导型蛋白激酶复合物及其使用方法

    公开(公告)号：US06258579B1

    公开(公告)日：2001-07-10

    申请号：US08910820

    申请日：1997-08-13

    申请人： Frank Mercurio ,  Hengyi Zhu ,  Miguel Barbosa ,  Jian Wu Li ,  Brion W. Murray

    发明人： Frank Mercurio ,  Hengyi Zhu ,  Miguel Barbosa ,  Jian Wu Li ,  Brion W. Murray

    IPC分类号： C12N912

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4702

    摘要： Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.

    摘要翻译： 提供用于治疗NF-κB相关病症的组合物和方法。 特别地，本发明提供了一种刺激诱导型IKK信号通路及其组件和变体。 IKK信号或其组分可用于例如鉴定通过NF-κB级联抑制或激活信号转导的抗体和其他调节剂。 IKK信号肽，其组分和/或调节剂也可用于治疗与NF-κB活化相关的疾病。

    Double-stranded RNAS directed to IKK-2
    3.
    发明授权
    Double-stranded RNAS directed to IKK-2 失效
    针对IKK-2的双链RNAS

    公开(公告)号：US07759476B2

    公开(公告)日：2010-07-20

    申请号：US11876570

    申请日：2007-10-22

    申请人： Frank Mercurio ,  Hengyi Zhu ,  Miguel Barbosa ,  Jian Wu Li ,  Brion W. Murray

    发明人： Frank Mercurio ,  Hengyi Zhu ,  Miguel Barbosa ,  Jian Wu Li ,  Brion W. Murray

    IPC分类号： C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4702

    摘要： Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.

    摘要翻译： 提供组合物和方法用于治疗NF-和κB相关病症。 特别地，本发明提供了一种刺激诱导型IKK信号通路及其组件和变体。 IKK信号或其组分可用于例如鉴定通过NF-κB级联抑制或激活信号转导的抗体和其它调节剂。 IKK信号肽，其组分和/或调节剂也可用于治疗与NF-κB活化相关的疾病。

    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders
    9.
    发明申请
    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders 有权
    鉴定可用于治疗增殖性和分化性疾病的化合物的方法

    公开(公告)号：US20090297528A1

    公开(公告)日：2009-12-03

    申请号：US12315862

    申请日：2008-12-05

    申请人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    发明人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    IPC分类号： A61K39/395 ,  C12Q1/00 ,  G01N33/53 ,  C12Q1/68 ,  A61K38/02 ,  A61K31/7088

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/1709 ,  A61K39/3955 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/4703 ,  G01N2333/9015 ,  G01N2500/00 ,  G01N2500/04

    摘要： The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders.

    摘要翻译： 本发明涉及编码泛素连接酶的新的底物靶向亚基的核苷酸序列的发现，鉴定和表征。 本发明包括编码泛素连接酶的新型底物靶向亚基的核苷酸：FBP1，FBP2，FBP3，FBP4，FBP5，FBP6，FBP7，FBP8，FBP9，FBP10，FBP11，FBP12，FBP13，FBP14，FBP15，FBP16，FBP17，FBP18， FBP19，FBP20，FBP21，FBP22，FBP23，FBP24和FBP25，转基因小鼠，敲除小鼠，宿主细胞表达系统和由新型底物靶向亚基的核苷酸编码的蛋白质。 本发明涉及使用泛素连接酶的新型和已知的底物靶向亚基的筛选测定法来鉴定潜在的治疗剂，例如调节新型和已知的泛素的活性的新型和已知的泛素连接酶的小分子，化合物或衍生物和类似物 用于治疗增殖性和分化性疾病如癌症，主要机会性感染，免疫疾病，某些心血管疾病和炎症性疾病的连接酶。 本发明还包括旨在靶向泛素连接酶及其底物以治疗增殖性和分化性疾病的治疗方案和药物组合物。

    METHOD AND APPARATUS FOR CLEANING THE CUTTING SYSTEM OF AN ELECTRIC SHAVER
    10.
    发明申请
    METHOD AND APPARATUS FOR CLEANING THE CUTTING SYSTEM OF AN ELECTRIC SHAVER 失效
    清洁电动剃须刀切割系统的方法和装置

    公开(公告)号：US20080210271A1

    公开(公告)日：2008-09-04

    申请号：US12030027

    申请日：2008-02-12

    申请人： James E. Chasen ,  Scott Larsen ,  Frank Mercurio ,  Stephen D. Mowers ,  Timothy G. Simmone

    发明人： James E. Chasen ,  Scott Larsen ,  Frank Mercurio ,  Stephen D. Mowers ,  Timothy G. Simmone

    IPC分类号： A45D27/46 ,  B08B3/04 ,  B26B19/38 ,  B08B3/14 ,  B08B3/02

    CPC分类号： A45D27/46 ,  B08B3/02

    摘要： By providing a shaver receiving and supporting housing which is constructed for enabling cleaning fluid to be delivered directly to the interior of a shaver in a highly efficient manner, a fully integrated shaving cleaning system is realized which is capable of providing automated cleaning of the shaver in an efficient and effective manner. In accordance with the present invention, the cleaning fluid if forced through portals formed in the shaver for enabling the fluid to be forcibly delivered directly into the hair pocket of the shaver, thereby enabling the surfaces of the hair pocket, the cutting foils, and the cutting blades to be completely and thoroughly cleaned, with the fluid draining out of the shaver through the cutting foils. In addition, the present invention is constructed for thoroughly and completely cleaning both rotary shavers and foil shavers.

    摘要翻译： 通过提供一种剃须刀接收和支撑壳体，其被构造用于使清洁流体能够以高效的方式直接输送到剃须刀的内部，实现了完全集成的剃刮清洁系统，其能够提供剃须刀的自动清洁 高效有效的方式。 根据本发明，如果强制通过形成在剃须刀中的入口的清洁流体，以使流体能够被强制地输送到剃须刀的毛发袋中，从而使得头发袋，切割箔和 切割刀片被完全和彻底地清洁，液体通过切割箔从剃须刀排出。 此外，本发明构造成用于彻底且全面地清洁旋转剃须刀和箔片剃须刀。