公开(公告)号：US07734342B2

公开(公告)日：2010-06-08

申请号：US11669758

申请日：2007-01-31

申请人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/00

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US07191018B2

公开(公告)日：2007-03-13

申请号：US10881239

申请日：2004-06-30

申请人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as_electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗，例如电刺激和/或药物输注到精确的靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US08600495B2

公开(公告)日：2013-12-03

申请号：US12794363

申请日：2010-06-04

申请人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/00

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US06319241B1

公开(公告)日：2001-11-20

申请号：US09303145

申请日：1999-04-30

申请人： Gary W. King ,  Frans Gielen ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Gary W. King ,  Frans Gielen ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61M3100

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： The present invention addresses the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. The present invention discloses techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy. The present invention also discloses techniques for non-invasively positioning and re-positioning therapy delivery elements after implant to provide electrical stimulation and/or drug infusion to a precise target. A position control mechanism and/or a position controller are provided for adjusting in situ the position of the therapy delivery elements relative to the targeted tissue of interest. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system may be provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

公开(公告)号：US20100241179A1

公开(公告)日：2010-09-23

申请号：US12794363

申请日：2010-06-04

申请人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/05 ,  A61N1/375 ,  A61M39/00

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US06795737B2

公开(公告)日：2004-09-21

申请号：US09934001

申请日：2001-08-21

申请人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary W. King ,  Daryle Petersen ,  Mark T. Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N118

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗疗法，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US20070123954A1

公开(公告)日：2007-05-31

申请号：US11669758

申请日：2007-01-31

申请人： Frans Gielen ,  Gary King ,  Daryle Petersen ,  Mark Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary King ,  Daryle Petersen ,  Mark Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/36

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US20070039625A1

公开(公告)日：2007-02-22

申请号：US11374793

申请日：2006-03-14

申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

IPC分类号： A61B19/00

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz) frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.

摘要翻译： 描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。 该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。 例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。 还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输注泵的系统。

公开(公告)号：US20070021802A1

公开(公告)日：2007-01-25

申请号：US11375492

申请日：2006-03-14

申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

IPC分类号： A61N1/34

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.

摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。 描述了通过植入式输注系统递送疼痛治疗剂。 还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。

公开(公告)号：US20070021801A1

公开(公告)日：2007-01-25

申请号：US11374852

申请日：2006-03-14

申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel ,  Gary King

发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel ,  Gary King

IPC分类号： A61N1/34

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.

摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。 还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。