公开(公告)号：US20070021801A1

公开(公告)日：2007-01-25

申请号：US11374852

申请日：2006-03-14

申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel ,  Gary King

发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel ,  Gary King

IPC分类号： A61N1/34

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.

摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。 还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

公开(公告)号：US20060259099A1

公开(公告)日：2006-11-16

申请号：US11401100

申请日：2006-04-10

申请人： Steven Goetz ,  Andrew Houchins ,  Jeffrey Keacher ,  Gary King ,  Kenneth Heruth ,  Roy Testerman ,  Michael Lee ,  Nathan Torgerson ,  Joseph Nolan

发明人： Steven Goetz ,  Andrew Houchins ,  Jeffrey Keacher ,  Gary King ,  Kenneth Heruth ,  Roy Testerman ,  Michael Lee ,  Nathan Torgerson ,  Joseph Nolan

IPC分类号： A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36071 ,  A61N1/36185 ,  A61N1/37252

摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

公开(公告)号：US20070073356A1

公开(公告)日：2007-03-29

申请号：US11450133

申请日：2006-06-09

申请人： Ethan Rooney ,  Carl Wahlstrand ,  Gary King ,  Thomas Cross ,  Jeffrey Evanson ,  Kenneth Heruth ,  Paul Wacnik

发明人： Ethan Rooney ,  Carl Wahlstrand ,  Gary King ,  Thomas Cross ,  Jeffrey Evanson ,  Kenneth Heruth ,  Paul Wacnik

IPC分类号： A61N1/32

CPC分类号： A61N1/36021 ,  A61M5/14 ,  A61M5/142 ,  A61M2205/054 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/37211 ,  A61N1/375

摘要： Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

摘要翻译： 描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。 与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。 包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。 此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

公开(公告)号：US20070245318A1

公开(公告)日：2007-10-18

申请号：US11402657

申请日：2006-04-12

申请人： Steven Goetz ,  Donald Johnson ,  Andrew Houchins ,  Jeffrey Keacher ,  Theodore Stone ,  Kenneth Heruth ,  Gary King ,  Roy Testerman

发明人： Steven Goetz ,  Donald Johnson ,  Andrew Houchins ,  Jeffrey Keacher ,  Theodore Stone ,  Kenneth Heruth ,  Gary King ,  Roy Testerman

IPC分类号： G06F9/44

CPC分类号： A61N1/37264 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63 ,  G16H50/20

摘要： Techniques that involve application of one or more rules to a “parent” program to generate a plurality of different “child” programs are described. Each of the rules may define a respective electrode configuration modification, and each child program may be a variation of the parent based on a modification of the electrode configuration of the parent according to one of the rules. The systems or devices may generate further generations of child programs from a previous generation child program using the same one or more rules. The child programs may be provided to a user, so that the user may test the efficacy of the new programs, assisting the user in identifying desirable programs. The child programs may be relatively minor variations of the parent program, and the user may “fine tune” a generally desirable parent program by testing the child programs.

摘要翻译： 描述涉及将一个或多个规则应用于“父”程序以生成多个不同的“子”程序的技术。 每个规则可以限定相应的电极配置修改，并且每个子程序可以是基于根据规则之一的父母的电极配置的修改的父母的变体。 系统或设备可以使用相同的一个或多个规则从上一代子程序生成更多代的子程序。 子程序可以被提供给用户，使得用户可以测试新程序的功效，帮助用户识别期望的程序。 子程序可能是父程序的相对小的变化，并且用户可以通过测试子程序来“微调”通常期望的父程序。

公开(公告)号：US20070073357A1

公开(公告)日：2007-03-29

申请号：US11450144

申请日：2006-06-09

申请人： Ethan Rooney ,  Carl Wahlstrand ,  Gary King ,  Thomas Cross ,  Jeffrey Evanson ,  Kenneth Heruth ,  Paul Wacnik

发明人： Ethan Rooney ,  Carl Wahlstrand ,  Gary King ,  Thomas Cross ,  Jeffrey Evanson ,  Kenneth Heruth ,  Paul Wacnik

IPC分类号： A61N1/32

CPC分类号： A61N1/36071 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/36021 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/375 ,  A61N1/3756

摘要： Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

摘要翻译： 描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。 与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。 包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。 此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

公开(公告)号：US20060229687A1

公开(公告)日：2006-10-12

申请号：US11352389

申请日：2006-02-10

申请人： Steven Goetz ,  Andrew Houchins ,  Jeffrey Keacher ,  Gary King ,  Kenneth Heruth ,  Roy Testerman ,  Michael Lee ,  Nathan Torgerson ,  Joseph Nolan

发明人： Steven Goetz ,  Andrew Houchins ,  Jeffrey Keacher ,  Gary King ,  Kenneth Heruth ,  Roy Testerman ,  Michael Lee ,  Nathan Torgerson ,  Joseph Nolan

IPC分类号： A61N1/18

CPC分类号： A61N1/36185 ,  A61N1/36071

摘要： In general, the invention is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. The stimulation pulses of the first and second electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, thereby allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find the most efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

摘要翻译： 通常，本发明涉及用于在两个电极组合之间移动的技术。 第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。 第一和第二电极组合的刺激脉冲在时间上交付给患者。 以这种方式，本发明提供了从第一电极组合到第二电极组合的平滑的逐渐变化，从而允许患者保持对刺激的连续感知。 在编程期间可以使用本文描述的移位技术来在不同的电极组合之间移动以找到最有效的电极组合。 另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

公开(公告)号：US20070123954A1

公开(公告)日：2007-05-31

申请号：US11669758

申请日：2007-01-31

申请人： Frans Gielen ,  Gary King ,  Daryle Petersen ,  Mark Rise ,  Michael Schendel ,  Warren Starkebaum

发明人： Frans Gielen ,  Gary King ,  Daryle Petersen ,  Mark Rise ,  Michael Schendel ,  Warren Starkebaum

IPC分类号： A61N1/36

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2209/045 ,  A61M2210/0693 ,  A61M2210/1003 ,  A61N1/05 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/36071

摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.

摘要翻译： 用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。 公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。 此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。 治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。 可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

公开(公告)号：US10692391B2

公开(公告)日：2020-06-23

申请号：US16551889

申请日：2019-08-27

申请人： Gary King ,  Eric Mazur ,  Kelly Miller ,  Brian Lukoff

发明人： Gary King ,  Eric Mazur ,  Kelly Miller ,  Brian Lukoff

IPC分类号： G09B5/02 ,  G09B7/02 ,  G06N20/00 ,  G06N20/20 ,  G06N5/00 ,  G06N7/00 ,  G06F40/40 ,  G06F40/169 ,  G09B5/12

摘要： In various embodiments, subject matter for improving discussions in connection with an educational resource is identified and summarized by analyzing annotations made by students assigned to a discussion group to identify high-quality annotations likely to generate responses and stimulate discussion threads, identifying clusters of high-quality annotations relating to the same portion or related portions of the educational resource, extracting and summarizing text from the annotations, and combining, in an electronically represented document, the extracted and summarized text and (i) at least some of the annotations and the portion or portions of the educational resource or (ii) clickable links thereto.

公开(公告)号：US08954520B2

公开(公告)日：2015-02-10

申请号：US13393204

申请日：2011-11-11

申请人： Nick Triantos ,  Abraham Benjamin de Waal ,  Gary King

发明人： Nick Triantos ,  Abraham Benjamin de Waal ,  Gary King

IPC分类号： G06F15/16 ,  G06Q10/10

CPC分类号： H04L51/046 ,  G06F3/04842 ,  G06Q10/103

摘要： System and methods for managing content modification messages are provided. In some embodiments, a request to send a modification message to a second user is received from a first user. The request to send the modification message pertains to a modification made to a first user-specific version corresponding to the first user and represented by a first delta. The modification message comprising a second delta is generated. The modification message includes second instructions to modify a second user-specific version to include the modification within the second user-specific version by resolving the first delta and the first user-specific version to the second user-specific version. A message indicator for the modification message is provides to a client device of the second user. The message indicator identifies the first user as the sender of the modification message.

摘要翻译： 提供了管理内容修改消息的系统和方法。 在一些实施例中，从第一用户接收向第二用户发送修改消息的请求。 发送修改消息的请求涉及对应于第一用户并由第一增量表示的对第一用户特定版本的修改。 生成包括第二增量的修改消息。 修改消息包括通过将第一增量和第一用户特定版本解析为第二用户特定版本来修改第二用户特定版本以将修改包括在第二用户特定版本内的第二指令。 用于修改消息的消息指示符被提供给第二用户的客户端设备。 消息指示符将第一个用户标识为修改消息的发送者。

公开(公告)号：US20080058878A1

公开(公告)日：2008-03-06

申请号：US11930767

申请日：2007-10-31

申请人： Gary King

发明人： Gary King

IPC分类号： A61N1/34 ,  A61N1/32 ,  A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/36007 ,  A61N1/36071

摘要： A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and/or direct current pulses at or near the second site. Timex varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be defibrillation of the patient's atria or defibrillation of the patient's ventricles, and the undesired side effect may be pain.

摘要翻译： 通过在患者体内的第一部位进行治疗活化的组织产生期望的效果，并且通过施加高频刺激和/或使患者的身体内的第二部位阻止组织的激活或动作电位的传导来减少相应的不期望的副作用，和/ 或在第二位置处或附近的直流脉冲。 可以在高频阻塞信号之前或之后使用Timex变化的DC脉冲。 高频刺激可以在治疗激活期间开始并且在治疗激活期间继续。 高频刺激可以以相对低的幅度开始，并且幅度可能逐渐增加。 期望的效果可以是患者心房的除颤或患者心室的除颤，并且不期望的副作用可能是疼痛。