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1.发明授权DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy 失效DTPA衍生物以新颖的方式取代，其金属络合物及其在诊断和治疗中的应用
公开(公告)号：US5746995A
公开(公告)日：1998-05-05
申请号：US565025
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds and their use as contrast media and antidotes.
摘要翻译： 本发明涉及含有原子序数20-32,39-51或57-83的元素的新的二亚乙基三胺五乙酸衍生物，其络合物和络合盐，含有这些化合物的药物及其作为造影介质和解毒剂的用途。
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2.发明授权Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents 失效倍增取代的DTPA衍生物及其金属络合物及其金属络合物，含有这些复合物的药物，它们在诊断和治疗中的应用，以及制备药剂的方法
公开(公告)号：US5885548A
公开(公告)日：1999-03-23
申请号：US565024
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds, their use as contrast media and antidotes, and process for the production of pharmaceutical agents.
摘要翻译： 本发明涉及含有原子序数20-32,39-51或57-83的元素的新的多取代的二亚乙基三胺五乙酸衍生物，它们的配合物和络合盐，含有这些化合物的药剂，它们作为造影介质的用途和 解毒剂，以及生产药剂的方法。
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3.发明授权
公开(公告)号：US5672335A
公开(公告)日：1997-09-30
申请号：US487094
申请日：1995-06-06
申请人： Werner Krause , Thomas Balzer , Wolf-Rudiger Press , Gabriele Schuhmann-Giampieri , Ulrich Speck , Andreas Muhler
发明人： Werner Krause , Thomas Balzer , Wolf-Rudiger Press , Gabriele Schuhmann-Giampieri , Ulrich Speck , Andreas Muhler
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer tomography of the liver and the biliary tracts.
摘要翻译： 含有原子序数39-42,44-51或56-83的金属和络合剂的金属络合物可用于生产用于肝脏和胆道的对比度增强计算机断层摄影术的造影剂。
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4.发明授权Use of tetra azacycle complexes as x-ray diagnostic agents for the liver and gallbladder 失效使用四氮基复合物作为肝和胆囊的X射线诊断剂
公开(公告)号：US5853699A
公开(公告)日：1998-12-29
申请号：US565397
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The disclosed metal complexes are suitable as contrast media for computer tomography of the liver and the biliary tracts.
摘要翻译： 所公开的金属络合物适合作为肝脏和胆道的计算机断层摄影的造影剂。
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5.发明授权公开(公告)号：US06638913B1
公开(公告)日：2003-10-28
申请号：US09504108
申请日：2000-02-14
IPC分类号： A01N4304
CPC分类号： A61K49/0452 , A61K9/0019 , A61K45/06 , A61K47/02 , A61K47/183
摘要： Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these additives are described.
摘要翻译： 描述了避免或减轻急性或延迟性超敏反应的浓缩注射和输注溶液的添加剂以及含有这些添加剂的注射和输注溶液。
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6.发明授权Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them 失效含有5或6元环的大环多氮化合物，其制备方法和含有它们的药物介质
公开(公告)号：US5403572A
公开(公告)日：1995-04-04
申请号：US213431
申请日：1994-03-15
申请人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
发明人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
IPC分类号： A61K49/06 , A61K51/04 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07F5/00 , A61B5/055 , C07D267/22
CPC分类号： C07F5/003 , A61K49/06 , A61K51/04 , A61K51/0482 , C07D255/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
摘要翻译： 下文定义的下式I和IV的大环化合物及其与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的诊断和治疗剂。
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7.发明授权Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI 失效含有5或6元环的马可环多氮杂双环化合物，以及MRI的方法
公开(公告)号：US5334371A
公开(公告)日：1994-08-02
申请号：US907929
申请日：1992-07-06
申请人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
发明人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
IPC分类号： A61K49/06 , A61K51/04 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07F5/00 , A61B5/055 , A61K31/44 , C07D225/00
CPC分类号： C07F5/003 , A61K49/06 , A61K51/04 , A61K51/0482 , C07D255/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
摘要翻译： 下文定义的下式I和IV的大环化合物及其与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的诊断和治疗剂。
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公开(公告)号：US08608689B2
公开(公告)日：2013-12-17
申请号：US12671910
申请日：2008-08-01
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
IPC分类号： A61M25/12
CPC分类号： A61M25/1029 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/204 , A61L2300/21 , A61L2300/22 , A61L2300/602 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , B05D1/26
摘要： This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
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公开(公告)号：US20130023817A1
公开(公告)日：2013-01-24
申请号：US13628627
申请日：2012-09-27
IPC分类号： A61M37/00
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.
摘要翻译： 本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种药物或药物制剂和至少一种亲脂性抗氧化剂，其比例为至少一种亲脂性抗氧化剂的3-100重量％ 相对于100重量％的药物，其中排除了至少一种药物和至少一种亲脂性抗氧化剂作为药物的组合，其中所述至少一种亲脂性抗氧化剂是丁基化羟基甲苯。
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公开(公告)号：US20110295200A1
公开(公告)日：2011-12-01
申请号：US13143703
申请日：2010-01-08
CPC分类号： A61L29/16 , A61L29/06 , A61L2300/216 , A61L2300/416 , A61L2300/602 , A61L2300/63 , A61M25/1002 , A61M25/1029 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , C08L77/00
摘要： The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.
摘要翻译： 本发明涉及一种药物洗脱医学装置，特别是用于血管成形术导管的气囊，其具有药物洗脱以防止经血管成形术的血管的再狭窄。 更具体地说，本发明涉及完全或部分地涂覆有水合结晶形式的紫杉醇或水合溶剂化晶体形式的导管球囊，其在干预部位具有治疗有效量的紫杉醇的即时释放和生物利用度。 气球可以由聚醚 - 聚酰胺嵌段共聚物或聚酯酰胺或聚酰胺-12制成。
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