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公开(公告)号：US06610846B1
公开(公告)日：2003-08-26
申请号：US09675781
申请日：2000-09-28
申请人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07D23724
CPC分类号： C07D213/75 , C07C275/50 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/135
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 所述3-取代的N-取代的N-杂芳族丙酰胺，其3-位取代为取代苯基，2-位是甲基环烷基环，所述丙酰胺为增加胰岛素分泌的葡萄糖激酶活化剂 II型糖尿病
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公开(公告)号：US07223868B2
公开(公告)日：2007-05-29
申请号：US11098717
申请日：2005-04-04
申请人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07D213/75 , C07D213/84
CPC分类号： C07D213/75 , C07C275/50 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/135
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 所述3-取代的N-取代的N-杂芳族丙酰胺，其3-位取代为取代苯基，2-位是甲基环烷基环，所述丙酰胺为增加胰岛素分泌的葡萄糖激酶活化剂 II型糖尿病
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公开(公告)号：US06951945B2
公开(公告)日：2005-10-04
申请号：US10616359
申请日：2003-07-09
申请人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07C275/50 , C07C317/44 , C07C323/62 , C07D213/75 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/22 , C07D239/42 , C07D241/20 , C07D241/28 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/18 , C07D277/38 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/12 , C07D285/135 , C07D285/06 , C07D275/02 , C07D277/04
CPC分类号： C07D213/75 , C07C275/50 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/135
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 所述3-取代的N-取代的N-杂芳族丙酰胺，其3-位取代为取代苯基，2-位是甲基环烷基环，所述丙酰胺为增加胰岛素分泌的葡萄糖激酶活化剂 II型糖尿病
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公开(公告)号：US06528543B1
公开(公告)日：2003-03-04
申请号：US09532506
申请日：2000-03-21
申请人： Fred Thomas Bizzarro , Wendy Lea Corbett , Antonio Focella , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Fred Thomas Bizzarro , Wendy Lea Corbett , Antonio Focella , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： A61K3117
CPC分类号： C07C275/50 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/75 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/22 , C07D239/42 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/135
摘要： Glucokinase activating compounds of the formula wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R3 is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R4 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R5 and R6 are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof
摘要翻译： 格列酰脲活性化合物R1和R2独立地是氢，卤素，氨基，硝基，氰基，亚磺酰氨基，低级烷基，全氟低级烷基，低级烷基硫代，全氟低级烷基硫代，低级烷基磺酰基或全氟低级烷基 磺酰基 R3是具有3至7个碳原子的环烷基或具有2至4个碳原子的低级烷基; R4是氢，低级烷基，低级烯基，羟基低级烷基，卤代低级烷基，R5和R6是氢或低级烷基; 且n为0,1,2,3或4; 或其药学上可接受的盐
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公开(公告)号：US06320050B1
公开(公告)日：2001-11-20
申请号：US09526143
申请日：2000-03-15
申请人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Ramakanth Sarabu
发明人： Fred Thomas Bizzarro , Wendy Lea Corbett , Joseph Francis Grippo , Nancy-Ellen Haynes , George William Holland , Robert Francis Kester , Ramakanth Sarabu
IPC分类号： C07D27738
CPC分类号： C07D213/75 , C07C275/50 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/80 , C07D213/82 , C07D233/88 , C07D237/22 , C07D239/42 , C07D241/20 , C07D253/07 , C07D261/14 , C07D263/48 , C07D277/46 , C07D277/56 , C07D277/58 , C07D285/135
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 2,3-二取代的N-杂芳族丙酰胺，其中2-取代为取代苯基，3-位是环烷基环，所述丙酰胺是葡萄糖激酶活化剂，其在II型治疗中增加胰岛素分泌 糖尿病。
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公开(公告)号：US06441184B1
公开(公告)日：2002-08-27
申请号：US10006168
申请日：2001-12-04
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07D27776
CPC分类号： C07D215/38 , C07D235/30 , C07D263/58 , C07D277/82
摘要： Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
摘要翻译： 葡萄糖激酶活化酰胺可用于在治疗II型糖尿病中增加胰岛素分泌。
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7.发明授权公开(公告)号：US07259166B2
公开(公告)日：2007-08-21
申请号：US11402167
申请日：2006-04-10
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
IPC分类号： C07D241/20 , C07D213/75 , C07D277/46 , C07D409/12
CPC分类号： C07D213/75 , C07C275/50 , C07C2601/08 , C07D241/20 , C07D277/46 , C07D307/16 , C07D309/04 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 2,3-二取代的N-杂芳族丙酰胺，其中2-取代为取代苯基，3-位是极性环，所述丙酰胺是葡萄糖激酶活化剂，其在II型治疗中增加胰岛素分泌 糖尿病。
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公开(公告)号：US07105671B2
公开(公告)日：2006-09-12
申请号：US10421109
申请日：2003-04-23
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
IPC分类号： C07D241/20 , C07D213/75 , C07D277/46 , C07D409/12
CPC分类号： C07D213/75 , C07C275/50 , C07C2601/08 , C07D241/20 , C07D277/46 , C07D307/16 , C07D309/04 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
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公开(公告)号：US06448399B1
公开(公告)日：2002-09-10
申请号：US10007091
申请日：2001-12-04
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07D25310
CPC分类号： C07D215/38 , C07D235/30 , C07D263/58 , C07D277/82
摘要： Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
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公开(公告)号：US06545155B2
公开(公告)日：2003-04-08
申请号：US10006170
申请日：2001-12-04
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Ramakanth Sarabu
IPC分类号： C07D21538
CPC分类号： C07D215/38 , C07D235/30 , C07D263/58 , C07D277/82
摘要： Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.
摘要翻译： 公开了用于治疗II型糖尿病中用于增加胰岛素分泌的葡糖激酶活化酰胺。
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