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公开(公告)号：US20060216289A1
公开(公告)日：2006-09-28
申请号：US11448387
申请日：2006-06-06
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体 。 它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。
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公开(公告)号：US20050221330A1
公开(公告)日：2005-10-06
申请号：US10621855
申请日：2003-07-16
IPC分类号： G01N33/68 , A61K39/395 , A61K45/00 , A61P1/02 , A61P1/10 , A61P11/06 , A61P17/02 , A61P25/02 , A61P25/06 , A61P27/02 , C07K14/71 , C07K16/28 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/42 , G01N33/573 , C12Q1/68 , C07H21/04
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和表达哺乳动物GFRalpha3的免疫粘附和宿主细胞，以及GDNF（即GFR）受体家族的新型α-亚基受体 。 它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。
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公开(公告)号：US20070232535A1
公开(公告)日：2007-10-04
申请号：US11529680
申请日：2006-09-27
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体 。 它进一步涉及通过检测酪氨酸激酶受体活化（即自身磷酸化）或与配体诱导的亚单位受体均二聚化或同型寡聚化相关的其它活性来测量α亚基受体活化的测定法。
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公开(公告)号：US07259245B2
公开(公告)日：2007-08-21
申请号：US10174653
申请日：2002-06-17
CPC分类号： C12N9/1205 , C07K14/705 , C07K16/40 , C07K2319/00 , C12N2799/026 , G01N2500/04
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，表达免疫粘附素，激动剂和对人和脊椎动物融合的拮抗剂（包括抗体）。
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公开(公告)号：US08394939B2
公开(公告)日：2013-03-12
申请号：US11536932
申请日：2006-09-29
CPC分类号： C12N9/1205 , C07K14/705 , C07K16/40 , C07K2319/00 , C12N2799/026 , G01N2500/04
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，表达免疫粘附素，激动剂和对人和脊椎动物融合的拮抗剂（包括抗体）。
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公开(公告)号：US6022708A
公开(公告)日：2000-02-08
申请号：US031563
申请日：1998-02-26
IPC分类号： G01N33/50 , C07K14/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/54 , C12Q1/48 , G01N33/15 , G01N33/68 , C12P21/02 , C12N15/63
CPC分类号： C12N9/1205 , C07K2319/00
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，载体和表达人和脊椎动物融合蛋白的免疫粘附素，激动剂和拮抗剂的宿主细胞。
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公开(公告)号：US06531579B1
公开(公告)日：2003-03-11
申请号：US09258000
申请日：1999-02-25
IPC分类号： C12P2102
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，载体和表达人和脊椎动物融合蛋白的免疫粘附素，激动剂和拮抗剂的宿主细胞。
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公开(公告)号：US06451977B1
公开(公告)日：2002-09-17
申请号：US09392277
申请日：1999-09-03
IPC分类号： C07K1447
CPC分类号： C12N9/1205 , C07K14/705 , C07K16/40 , C07K2319/00 , C12N2799/026 , G01N2500/04
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptide, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，载体和宿主细胞，表达免疫粘附素，激动剂和对人和脊椎动物融合的拮抗剂。
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公开(公告)号：US20070042415A1
公开(公告)日：2007-02-22
申请号：US11536932
申请日：2006-09-29
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/1205 , C07K14/705 , C07K16/40 , C07K2319/00 , C12N2799/026 , G01N2500/04
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，表达免疫粘附素，激动剂和对人和脊椎动物融合的拮抗剂（包括抗体）。
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公开(公告)号：US20050196814A1
公开(公告)日：2005-09-08
申请号：US11096396
申请日：2005-04-01
申请人： Frederic de Sauvage , Maximilien Murone , Arnon Rosenthal , Donna Stone , Austin Gurney , William Wood
发明人： Frederic de Sauvage , Maximilien Murone , Arnon Rosenthal , Donna Stone , Austin Gurney , William Wood
CPC分类号： C07K14/4703 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与黑腹果蝇融合蛋白的多肽抑制子和编码那些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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