-
公开(公告)号:US20060079543A1
公开(公告)日:2006-04-13
申请号:US11248495
申请日:2005-10-13
申请人: Fuk-Wah Sum , Dennis Powell , Yixian Zhang , Lijing Chen , Scott Kincaid , Lee Jennings , Yongbo Hu , Adam Gilbert , Matthew Bursavich
发明人: Fuk-Wah Sum , Dennis Powell , Yixian Zhang , Lijing Chen , Scott Kincaid , Lee Jennings , Yongbo Hu , Adam Gilbert , Matthew Bursavich
IPC分类号: A61K31/506 , C07D417/02 , C07D403/02
CPC分类号: C07D409/12 , C07D239/42 , C07D239/70 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D487/04
摘要: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
摘要翻译: 本发明涉及式I化合物:其中R 1,R 2,R 3,R 4, R 5,R 6和R 6在本文中定义。
-
公开(公告)号:US07799915B2
公开(公告)日:2010-09-21
申请号:US11248495
申请日:2005-10-13
申请人: Fuk-Wah Sum , Dennis William Powell , Yixian Zhang , Lijing Chen , Scott Lee Kincaid , Lee Dalton Jennings , Yongbo Hu , Adam Matthew Gilbert , Matthew Gregory Bursavich
发明人: Fuk-Wah Sum , Dennis William Powell , Yixian Zhang , Lijing Chen , Scott Lee Kincaid , Lee Dalton Jennings , Yongbo Hu , Adam Matthew Gilbert , Matthew Gregory Bursavich
IPC分类号: C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C07D409/12 , C07D239/42 , C07D239/70 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D487/04
摘要: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
摘要翻译: 本发明涉及式I化合物:其中R1,R2,R3,R4,R5和R6如本文所定义。
-
公开(公告)号:US20060063784A1
公开(公告)日:2006-03-23
申请号:US11221846
申请日:2005-09-09
申请人: Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
发明人: Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04 , A61K31/519
摘要: This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
摘要翻译: 本发明涉及使用某些吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐的新方法。 本发明还涉及在哺乳动物(包括人)中使用这些化合物作为抗增殖剂的新方法。
-
公开(公告)号:US20070244140A1
公开(公告)日:2007-10-18
申请号:US11786380
申请日:2007-04-10
申请人: Yongbo Hu , Fuk-Wah Sum , Martin Di Grandi , Emily Norton
发明人: Yongbo Hu , Fuk-Wah Sum , Martin Di Grandi , Emily Norton
IPC分类号: A61K31/506 , C07D403/02 , A61K31/505 , C07D239/32
CPC分类号: C07D409/12 , C07D239/42 , C07D409/04 , C07D409/14
摘要: The present invention relates to compounds of formula III: wherein R2, R3, R5 and R6 are as defined herein.
摘要翻译: 本发明涉及式III化合物:其中R 2,R 3,R 5和R 6, 如本文所定义。
-
公开(公告)号:US20100035957A1
公开(公告)日:2010-02-11
申请号:US12539074
申请日:2009-08-11
申请人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark L. Behnke , Baihua Hu , James D. Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
发明人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark L. Behnke , Baihua Hu , James D. Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
IPC分类号: A61K31/405 , A61P9/10 , A61P25/28
CPC分类号: A61K31/505 , C07D209/14 , C07D209/16 , C07D209/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/10
摘要: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.
摘要翻译: 本发明提供了使用通式的取代的吲哚化合物及其药学上可接受的盐形式的方法。 本发明提供了使用化合物作为各种磷脂酶,特别是磷脂酶A2酶的活性的抑制剂的方法,以及用于医学治疗,预防和抑制疾病和病症,包括哮喘,中风,动脉粥样硬化,多发性硬化,帕金森病, 关节炎疾病,风湿病,中风引起的中枢神经系统损伤,由缺血引起的中枢神经系统损伤,由创伤引起的中枢神经系统损伤,由前列腺素引起或增强的炎症,由白细胞三烯引起或增强的炎症,血小板引起或增强的炎症 活化因子,由前列腺素引起或增强的疼痛,由白三烯引起或加剧的疼痛,以及血小板激活因子引起或增强的疼痛。
-
6.
公开(公告)号:US20080312203A1
公开(公告)日:2008-12-18
申请号:US12195706
申请日:2008-08-21
申请人: Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin
发明人: Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin
IPC分类号: A61K31/424 , C07D503/10 , A61K31/431 , A61K31/546 , A61K31/5365 , C07D498/04 , A61K31/545 , A61K31/43 , A61P31/04
CPC分类号: C07D519/00 , C07D499/861 , C07D499/88 , C07D503/00
摘要: The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is O, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
摘要翻译: 本发明提供式Ⅰ化合物,其中A和B之一为氢,另一个为任选取代的稠合双环杂芳基; X是O,药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。
-
公开(公告)号:US07101875B2
公开(公告)日:2006-09-05
申请号:US10302087
申请日:2002-11-22
申请人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James D. Clark
发明人: John C. McKew , Steve Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James D. Clark
IPC分类号: A61K31/404 , A61K31/54 , A61K31/42 , A61K31/41 , A61K31/40
CPC分类号: C07D401/12 , C07D209/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/10
摘要: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
摘要翻译: 本发明提供使用以下通式的取代的吲哚化合物及其药学上可接受的盐形式来治疗哺乳动物关节炎或风湿病的方法,以及使用这些化合物作为各种磷脂酶的活性抑制剂的方法,特别是磷脂酶A 2酶,并用于治疗,预防和抑制疼痛和炎症。
-
公开(公告)号:US06984735B2
公开(公告)日:2006-01-10
申请号:US10722782
申请日:2003-11-26
申请人: John C. McKew , Steven Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James D. Clark , Wei Li
发明人: John C. McKew , Steven Y. Tam , Katherine L. Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James D. Clark , Wei Li
IPC分类号: C07D215/38 , C07D217/12
CPC分类号: C07D401/12 , C07D209/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/10
摘要: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
摘要翻译: 在没有有效量的活化剂的情况下,使亚砜与二卤代芳香族化合物反应的芳香醛的制造方法。 然后可以使用醛来制备其它化合物,例如充当cPLA抑制剂的化合物。
-
公开(公告)号:US06525202B2
公开(公告)日:2003-02-25
申请号:US09903754
申请日:2001-07-12
申请人: Baihua Hu , Fuk-Wah Sum , Michael S. Malamas
发明人: Baihua Hu , Fuk-Wah Sum , Michael S. Malamas
IPC分类号: C07D21158
CPC分类号: C07D401/10 , C07D211/58 , C07D223/12 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/10 , C07D417/14
摘要: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
摘要翻译: 本发明提供具有其中R1,R2,R3,R4,R5,T,T1,T2和X如上所定义的结构的式I化合物或其药学上可接受的盐,其可用于治疗或抑制代谢紊乱 与胰岛素抵抗或高血糖相关(通常与肥胖或葡萄糖不耐受相关),动脉粥样硬化,胃肠道疾病,神经源性炎症,青光眼,高眼压症和尿频; 并且特别可用于治疗或抑制II型糖尿病。
-
公开(公告)号:US5786353A
公开(公告)日:1998-07-28
申请号:US893497
申请日:1997-07-11
申请人: Jay Donald Albright , Marvin Fred Reich , Fuk-Wah Sum , Xuemei Du
发明人: Jay Donald Albright , Marvin Fred Reich , Fuk-Wah Sum , Xuemei Du
IPC分类号: C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/55 , A61K31/675 , C07D223/00 , C07D267/02
CPC分类号: C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
-
-
-
-
-
-
-
-
-