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公开(公告)号：US20190382381A1
公开(公告)日：2019-12-19
申请号：US16547734
申请日：2019-08-22
Inventor： Linda N. CASILLAS , John David HARLING , Afjal Hussain MIAH , Mark David RACKHAM , Ian Edward David SMITH
IPC: C07D403/14 , A61P29/00 , C07D487/04 , C07D417/14 , C07D401/14
Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.
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公开(公告)号：US20150361069A1
公开(公告)日：2015-12-17
申请号：US14762905
申请日：2014-02-19
Inventor： Linda N. CASILLAS , Adam Kenneth CHARNLEY , Xiaoyang DONG , Pamela A. HAILE , Michael P. DEMARTINO , John F. MEHLMANN
IPC: C07D403/12 , C07D405/14
CPC classification number: C07D403/12 , A61K9/2054 , A61K9/4866 , C07D405/14
Abstract: Disclosed are compounds that are inhibitors of RIP2 kinase and methods of making and using the same.
Abstract translation: 公开了作为RIP2激酶抑制剂的化合物及其制备和使用方法。
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公开(公告)号：US20180134688A1
公开(公告)日：2018-05-17
申请号：US15568025
申请日：2016-04-20
Inventor： Linda N. CASILLAS , John David HARLING , Afjal Hussain MIAH , Mark David RACKHAM , Ian Edward David SMITH
IPC: C07D403/14 , C07D401/14 , C07D487/04 , C07D417/14 , A61P29/00
CPC classification number: C07D403/14 , A61P29/00 , C07D401/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.
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公开(公告)号：US20180085365A1
公开(公告)日：2018-03-29
申请号：US15811712
申请日：2017-11-14
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Pamela A. HAILE , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Robert R. SINGHAUS, JR. , Gren Z. WANG
IPC: A61K31/4709 , A61K31/4706
CPC classification number: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20190119271A1
公开(公告)日：2019-04-25
申请号：US16094564
申请日：2017-04-18
Inventor： Linda N. CASILLAS , John David HARLING , Afjal Hussain MIAH , Mark David RACKHAM , Ian Edward David Smith
IPC: C07D471/04 , C07D417/14 , C07D471/10 , C07D519/00
Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.
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Patent Agency Ranking
公开(公告)号：US20170152233A1
公开(公告)日：2017-06-01
申请号：US15431942
申请日：2017-02-14
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam K. CHARNLEY , Michael P. DEMARTINO , Xiaoyang DONG , Patrick M. EIDAM , Pamela A. HAILE , Robert W. MARQUIS, JR. , Joshi M. RAMANJULU , Joseph J. ROMANO , Ami Lakdawala SHAH , Robert R. SINGHAUS, JR. , Gren WANG
IPC: C07D239/94 , C07D403/12 , C07D417/14 , C07D417/12
CPC classification number: C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20160060222A1
公开(公告)日：2016-03-03
申请号：US14934395
申请日：2015-11-06
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Michael P. DeMARTINO , Xiaoyang DONG , Patrick EIDAM , Pamela A. HAILE , Philip Anthony HARRIS , Ami Lakdawala SHAH , Bryan W. KING , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Clark A. SEHON
IPC: C07D215/42 , C07D215/44 , C07D401/12 , C07D405/12 , C07D411/12 , C07D215/48 , C07D471/04 , C07D417/14 , C07D513/04 , C07D405/14 , C07D401/14 , C07D417/12 , C07D413/12
CPC classification number: C07D215/42 , A61K31/47 , C07D215/44 , C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.
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公开(公告)号：US20170128437A1
公开(公告)日：2017-05-11
申请号：US15413792
申请日：2017-01-24
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Pamela A. HAILE , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Robert R. SINGHAUS, JR. , Gren Z. WANG
IPC: A61K31/4709 , A61K31/4706
CPC classification number: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20160060249A1
公开(公告)日：2016-03-03
申请号：US14933201
申请日：2015-11-05
Inventor： Linda N. CASILLAS , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Robert W. Marquis, JR. , John F. Mehlmann , Michael Reilly , Joseph J. Romano , Robert R. Singhaus, JR.
IPC: C07D401/12 , C07D405/14
CPC classification number: C07D401/12 , C07D405/14
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
Abstract translation: 公开了具有下式的化合物：其中R1，R2，R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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公开(公告)号：US20140256949A1
公开(公告)日：2014-09-11
申请号：US14283352
申请日：2014-05-21
Inventor： Linda N. CASILLAS , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Robert W. Marquis, JR. , John F. Mehlmann , Michael Reilly , Joseph J. Romano , Robert R. Singhaus, JR.
IPC: C07D405/14 , C07D401/12
CPC classification number: C07D401/12 , C07D405/14
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
Abstract translation: 公开了具有下式的化合物：其中R1，R2，R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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