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1.发明公开公开(公告)号：US20240123116A1
公开(公告)日：2024-04-18
申请号：US18046281
申请日：2022-10-13
申请人： GLOBUS MEDICAL, INC.
发明人： Bipin Gaihre , Archana Bhat
CPC分类号： A61L27/227 , A61L27/025 , A61L27/20 , A61L27/26 , A61L27/56 , B82Y5/00
摘要： The present invention relates to a thermoresponsive or shear-thinning gel composition comprising a recombinant factor (i.e., interleukin-1 receptor antagonist protein (IRAP) and/or platelet derived growth factor (PDGF)) and a carrier solution comprising at least one selected from hyaluronic acid (HA), chondroitin sulfate (CS), methyl cellulose (MC), and/or two-dimensional silicate nanomaterial. In some embodiments, the composition is an anti-inflammatory composition. Thus, in some embodiments, the present invention also provides a method of treating an inflammatory disease or disorder, such as osteoarthritis, using said composition.
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公开(公告)号：US20220168356A1
公开(公告)日：2022-06-02
申请号：US17672983
申请日：2022-02-16
申请人： GLOBUS MEDICAL, INC.
发明人： David C. Paul , Archana Bhat , Breanna Seiber
摘要： Allograft biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting cartilage, tissue, bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. For example, the allograft may include viable cells, for example, which were native to intervertebral discs and/or umbilical cords that the allograft was derived from.
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公开(公告)号：US20210369919A1
公开(公告)日：2021-12-02
申请号：US17405113
申请日：2021-08-18
申请人： GLOBUS MEDICAL, INC.
发明人： Archana Bhat , Shairali Rao , Daniel Laskowitz
摘要： Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof Also provided are kits that include the present bone grafts and/or constructs, or components thereof.
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公开(公告)号：US11116874B2
公开(公告)日：2021-09-14
申请号：US16009832
申请日：2018-06-15
申请人： GLOBUS MEDICAL, INC.
发明人： Archana Bhat , Shairali Rao , Daniel Laskowitz
摘要： Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof Also provided are kits that include the present bone grafts and/or constructs, or components thereof.
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公开(公告)号：US10016529B2
公开(公告)日：2018-07-10
申请号：US14735460
申请日：2015-06-10
申请人： GLOBUS MEDICAL, INC.
CPC分类号： A61L27/446 , A61L27/46 , A61L27/56 , A61L2430/02 , A61L2430/38 , C08L5/08 , C08L71/02
摘要： Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, osteoconductive, and/or osteostimulative properties.
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公开(公告)号：US11285177B2
公开(公告)日：2022-03-29
申请号：US16210464
申请日：2018-12-05
申请人： GLOBUS MEDICAL, INC.
发明人： David C. Paul , Archana Bhat , Breanna Seiber
IPC分类号： A61K35/32 , A61K38/39 , A61K35/51 , A61L27/36 , A61K35/33 , A01N1/02 , A61L27/38 , A61K31/728
摘要： Allograft biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting cartilage, tissue, bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. For example, the allograft may include viable cells, for example, which were native to intervertebral discs and/or umbilical cords that the allograft was derived from.
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公开(公告)号：US20170119929A1
公开(公告)日：2017-05-04
申请号：US15407702
申请日：2017-01-17
申请人： GLOBUS MEDICAL, INC.
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L2430/02
摘要： Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.
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公开(公告)号：US09579421B2
公开(公告)日：2017-02-28
申请号：US14175184
申请日：2014-02-07
申请人： GLOBUS MEDICAL, INC
发明人： Archana Bhat , Dan Laskowitz , Patrick Joe , Mark Adams , Michael Lee Boyer, II
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L2430/02
摘要： Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.
摘要翻译： 本文提供了骨移植物及其制备和使用方法，以及包括这种骨移植物的产品和试剂盒。 特别地，提供骨移植物，其包括成骨诱导的软骨骨架和骨诱导性皮质松质骨碎片混合中的成骨干细胞。
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公开(公告)号：US20160361467A1
公开(公告)日：2016-12-15
申请号：US14810858
申请日：2015-07-28
申请人： GLOBUS MEDICAL, INC.
发明人： Jennifer Klimek , Archana Bhat , Vipin Kunjachan , Chris Geisler , Allison Adams , Christine Grimes
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/2846 , A61F2/4455 , A61F2/447 , A61F2002/2835 , A61F2002/30733 , A61F2002/30787 , A61F2002/30904 , A61F2002/30971 , A61F2002/4475 , A61L27/10 , A61L27/12 , A61L27/427 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , A61L2430/38
摘要： Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, osteoconductive, and/or osteostimulative properties.
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公开(公告)号：US20150110748A1
公开(公告)日：2015-04-23
申请号：US14057860
申请日：2013-10-18
申请人： Globus Medical, Inc.
发明人： Archana Bhat , Shairali Rao , Daniel Laskowitz
IPC分类号： A61K35/28
CPC分类号： A61K35/28 , A61K35/32 , A61L27/3608 , A61L27/3834 , A61L27/3847 , A61L2430/02
摘要： Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof. Also provided are kits that include the present bone grafts and/or constructs, or components thereof.
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