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1.发明授权公开(公告)号：US08519358B2
公开(公告)日：2013-08-27
申请号：US12865186
申请日：2009-02-05
申请人： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
发明人： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
IPC分类号： G01J1/58
CPC分类号： G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译： 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。 该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。
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公开(公告)号：US20110008825A1
公开(公告)日：2011-01-13
申请号：US12682402
申请日：2008-10-10
申请人： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
发明人： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
CPC分类号： G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
摘要： A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
摘要翻译： 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于保持四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。
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公开(公告)号：US10288632B2
公开(公告)日：2019-05-14
申请号：US12885993
申请日：2010-09-20
申请人： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
发明人： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
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4.发明申请公开(公告)号：US20110042582A1
公开(公告)日：2011-02-24
申请号：US12865186
申请日：2009-02-05
申请人： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
发明人： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
CPC分类号： G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译： 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。 该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。
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公开(公告)号：US08808649B2
公开(公告)日：2014-08-19
申请号：US12682402
申请日：2008-10-10
申请人： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
发明人： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
CPC分类号： G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
摘要： A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
摘要翻译： 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于容纳四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。
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6.发明申请公开(公告)号：US20110093207A1
公开(公告)日：2011-04-21
申请号：US12885993
申请日：2010-09-20
申请人： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
发明人： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
CPC分类号： G01N35/025 , B04B9/14 , G01N2035/00504 , G01N2035/0434 , G01N2035/0458
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
摘要翻译： 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括用于在测试期间保持样品的预定最适温度的冷却，加热和风扇装置的系统; 用于使转盘内的样品对准的视觉，圆周和轴向对准系统; 将样品从转盘转移到离心机的转移系统; 使离心机的旋转振动最小化的平衡系统; 采样系统的安全系统和防倾翻设计; 用于分配缓冲盐溶液的液体分配臂; 以及用于将从样品去除的液体排放和处置到系统外部的位置的排出口。
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公开(公告)号：US07518710B2
公开(公告)日：2009-04-14
申请号：US11486619
申请日：2006-07-14
申请人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
发明人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
CPC分类号： G01N15/1463 , G01N2015/0261 , G01N2015/1488 , Y10T436/11 , Y10T436/115831
摘要： A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data. The processor determines whether the sample area includes predetermined biological or chemical particulates of interest based upon an analysis of the interrogation data and triggers an event such as an alarm or message if the predetermined biological or chemical particulates of interest are identified.
摘要翻译： 提供了一种生物和化学检测系统，用于检测和识别感兴趣的生物和/或化学颗粒物。 生物和化学检测系统包括收集器，第一光学装置，第二光学装置和处理器。 收集器被配置为将从流体流中吸取的微粒沉积到样品基底上以限定样品区域。 第一光学装置相对于样本区域的至少一部分导出第一数据，其被分析以确定至少一个视场和/或特定目标位置。 然后，第二光学装置在每个确定的目标位置询问样品区域，例如使用拉曼光谱法，产生询问数据。 处理器基于询问数据的分析来确定样本区域是否包括预期的生物或化学颗粒物，并且如果识别出预定的感兴趣的生物或化学颗粒物，则触发诸如报警或消息的事件。
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公开(公告)号：US20090066934A1
公开(公告)日：2009-03-12
申请号：US11486619
申请日：2006-07-14
申请人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
发明人： Johnway Gao , Jerome U. Gilberry , William A. Ivancic , John J. Kester , Joseph A. McClintock , Clark A. Morrow , Jason A. Schaefer
CPC分类号： G01N15/1463 , G01N2015/0261 , G01N2015/1488 , Y10T436/11 , Y10T436/115831
摘要： A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data. The processor determines whether the sample area includes predetermined biological or chemical particulates of interest based upon an analysis of the interrogation data and triggers an event such as an alarm or message if the predetermined biological or chemical particulates of interest are identified.
摘要翻译： 提供了一种生物和化学检测系统，用于检测和识别感兴趣的生物和/或化学颗粒物。 生物和化学检测系统包括收集器，第一光学装置，第二光学装置和处理器。 收集器被配置为将从流体流中吸取的微粒沉积到样品基底上以限定样品区域。 第一光学装置相对于样本区域的至少一部分导出第一数据，其被分析以确定至少一个视场和/或特定目标位置。 然后，第二光学装置在每个确定的目标位置询问样品区域，例如使用拉曼光谱法，产生询问数据。 处理器基于询问数据的分析来确定样品区域是否包括预期的生物或化学颗粒物，并且如果识别出预定的感兴趣的生物或化学颗粒物，则触发诸如报警或消息的事件。
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