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1.发明授权公开(公告)号：US07414169B2
公开(公告)日：2008-08-19
申请号：US09844353
申请日：2001-04-27
申请人： Gary Ruvkun , Koutarou Kimura , Garth Patterson , Scott Ogg , Suzanne Paradis , Heidi Tissenbaum , Jason Morris , Allison Koweek
发明人： Gary Ruvkun , Koutarou Kimura , Garth Patterson , Scott Ogg , Suzanne Paradis , Heidi Tissenbaum , Jason Morris , Allison Koweek
CPC分类号： A61K49/0004 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/70596 , G01N33/5085 , G01N2333/4353
摘要： Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
摘要翻译： 本文公开了用于筛选可用于治疗葡萄糖耐量异常病症的治疗剂的新基因和方法，以及用于鉴定或治疗这些病症的诊断和治疗组合物。
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公开(公告)号：US07094889B2
公开(公告)日：2006-08-22
申请号：US08908453
申请日：1997-08-07
申请人： Gary Ruvkun , Jason Morris , Heidi Tissenbaum
发明人： Gary Ruvkun , Jason Morris , Heidi Tissenbaum
IPC分类号： C07H21/04 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N5/00 , C12N5/02 , C12Q1/68 , G01N33/53
CPC分类号： C12N9/1205
摘要： Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.
摘要翻译： 公开了基本上纯的AGE-1多肽和纯化的DNA，载体和编码那些多肽的细胞。 还公开了使用AGE-1序列确定寿命和分离拮抗剂的方法。
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3.发明授权公开(公告)号：US06225120B1
公开(公告)日：2001-05-01
申请号：US08857076
申请日：1997-05-15
申请人： Gary Ruvkun , Koutarou Kimura , Garth Patterson , Scott Ogg , Suzanne Paradis , Heidi Tissenbaum , Jason Morris , Allison Koweek
发明人： Gary Ruvkun , Koutarou Kimura , Garth Patterson , Scott Ogg , Suzanne Paradis , Heidi Tissenbaum , Jason Morris , Allison Koweek
IPC分类号： C12N500
CPC分类号： A61K49/0004 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/70596 , G01N33/5085 , G01N2333/4353
摘要： Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
摘要翻译： 本文公开了用于筛选可用于治疗葡萄糖耐量异常病症的治疗剂的新基因和方法，以及用于鉴定或治疗这些病症的诊断和治疗组合物。
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公开(公告)号：US20080139492A1
公开(公告)日：2008-06-12
申请号：US10587735
申请日：2005-02-02
申请人： Gary Ruvkun , Scott Kennedy
发明人： Gary Ruvkun , Scott Kennedy
IPC分类号： C12Q1/68 , G01N33/00 , C07K14/00 , C07H21/00 , C12N15/11 , A01K67/027 , A01K67/033 , A01H5/00 , C12N5/10 , C12N15/80 , C12N15/85 , C12N15/74
CPC分类号： C12N15/111 , C12N15/8218 , C12N15/8279 , C12N2310/14 , C12N2320/50
摘要： The invention features nucleobase oligomeric compositions useful in enhancing RNA interference in a wide variety of cell types for the treatment of virtually any disease or disorder related to the overexpression of a gene or genes, as well as methods of identifying and using such compositions.
摘要翻译： 本发明具有用于增强各种细胞类型中的RNA干扰以用于治疗与基因或基因的过表达有关的任何疾病或病症的核碱基寡聚组合物，以及鉴定和使用这些组合物的方法。
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公开(公告)号：US20070087378A1
公开(公告)日：2007-04-19
申请号：US11641409
申请日：2006-12-19
申请人： Gary Ruvkun , Kaveh Ashrafi
发明人： Gary Ruvkun , Kaveh Ashrafi
CPC分类号： C12Q1/6883 , A01K67/0336 , A01K2217/05 , A61K38/00 , C07K14/43545 , C07K14/4702 , C12Q1/6837 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.
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6.发明授权公开(公告)号：US07175999B2
公开(公告)日：2007-02-13
申请号：US10617351
申请日：2003-07-10
申请人： Gary Ruvkun , Kaveh Ashrafi
发明人： Gary Ruvkun , Kaveh Ashrafi
IPC分类号： C12N15/09
CPC分类号： C12Q1/6883 , A01K67/0336 , A01K2217/05 , A61K38/00 , C07K14/43545 , C07K14/4702 , C12Q1/6837 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.
摘要翻译： 通常，本发明涉及涉及脂肪代谢调节的核酸和氨基酸序列以及这些序列作为诊断，治疗和预防肥胖症和肥胖相关疾病的靶标的用途。 此外，本发明涉及用于鉴定体脂肪代谢调节剂的筛选方法以及肥胖和肥胖相关疾病的治疗发展。
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公开(公告)号：US20050260652A1
公开(公告)日：2005-11-24
申请号：US11106238
申请日：2005-04-14
申请人： Gary Ruvkun , Ravi Kamath , Harrison Gabel , John Kim
发明人： Gary Ruvkun , Ravi Kamath , Harrison Gabel , John Kim
IPC分类号： A01K67/033 , C12N15/11 , C12Q1/68
CPC分类号： C12N15/111 , A01K2217/05 , A01K2217/075 , A01K2227/105 , C12N2310/14 , C12N2320/12 , C12N2320/50 , C12N2330/31
摘要： The invention features compositions useful in modulating RNA interference in a wide variety of cell types for the treatment of virtually any disease or disorder related to the overexpression of a gene or genes, as well as methods of identifying and using such compositions.
摘要翻译： 本发明的特征在于可用于调节多种细胞类型中的RNA干扰的组合物，用于治疗与基因或基因的过表达相关的任何疾病或病症，以及鉴定和使用这些组合物的方法。
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8.发明授权公开(公告)号：US06861256B2
公开(公告)日：2005-03-01
申请号：US09205658
申请日：1998-12-03
申请人： Gary Ruvkun , Scott Ogg
发明人： Gary Ruvkun , Scott Ogg
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K45/00 , A61K48/00 , A61K49/00 , A61P3/04 , A61P3/10 , C07K14/705 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/85 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , C12N5/00 , A01K67/00 , C07H21/04 , G01N33/00 , A61K40/00
CPC分类号： C12N15/8509 , A01K67/0336 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A61K38/00 , A61K49/0004 , C07K14/705 , C07K14/70596 , C12N9/16 , G01N33/5085 , G01N33/6875 , G01N2333/4353 , G01N2500/00
摘要： Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
摘要翻译： 本文公开了用于筛选可用于治疗葡萄糖耐量异常病症的治疗剂的新基因和方法，以及用于鉴定或治疗这些病症的诊断和治疗组合物。
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公开(公告)号：US20080064648A1
公开(公告)日：2008-03-13
申请号：US10556649
申请日：2004-06-16
申请人： Gary Ruvkun , Ho Yi Mak
发明人： Gary Ruvkun , Ho Yi Mak
CPC分类号： C07K14/001 , A01K2217/05 , A01K2217/058 , A01K2217/075 , A01K2227/703 , A01K2267/0362
摘要： In general, this invention relates to nucleic acid and amino acid sequences involved in lipid accumulation, screening methods for identifying genes that regulate lipid accumulation, and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases.
摘要翻译： 通常，本发明涉及参与脂质积累的核酸和氨基酸序列，用于鉴定调节脂质积累的基因的筛选方法，以及这些序列作为诊断，治疗和预防肥胖和肥胖相关的靶标的用途 疾病
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公开(公告)号：US20060178292A1
公开(公告)日：2006-08-10
申请号：US10540445
申请日：2003-12-31
申请人： Gary Ruvkun , Alison Frand
发明人： Gary Ruvkun , Alison Frand
IPC分类号： A01N37/18 , C12Q1/68 , G01N33/567 , G01N33/53
CPC分类号： C07K14/4354 , C07K14/43545 , C07K14/43563 , C12N15/8285 , C12N15/8286 , G01N33/5085 , G01N2333/4353 , Y02A40/162 , Y02A40/164
摘要： In general, this invention relates to nucleic acid and amino acid sequences involved in molting and the use of these sequences as targets for the development of compounds that disrupt Ecdysozoan molting, and are useful as insecticides, nematicides, and anti-parasitic agents.
摘要翻译： 一般来说，本发明涉及涉及蜕皮的核酸和氨基酸序列，以及这些序列作为用于开发破坏生态土壤蜕皮的化合物的目标的用途，并且可用作杀虫剂，杀线虫剂和抗寄生虫剂。
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