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公开(公告)号：US08415477B2
公开(公告)日：2013-04-09
申请号：US13149392
申请日：2011-05-31
申请人： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
发明人： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
IPC分类号： C07D413/04 , C07D417/04
CPC分类号： C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
摘要： The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
摘要翻译： 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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公开(公告)号：US20070077549A1
公开(公告)日：2007-04-05
申请号：US11535458
申请日：2006-09-26
申请人： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
发明人： Gayle Buller , Jixiang Liu , Stephen Yue , Jolene Bradford
IPC分类号： C12Q1/00 , C07D413/02 , C07F9/58 , C07F9/82 , C07F7/02
CPC分类号： C09B23/0075 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/6441
摘要： The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
摘要翻译： 本发明提供了在约400nm处最佳激发并具有至少约80nm的斯托克斯位移的染料化合物。 这些染料可用于检测样品中的分析物和染料缀合物的制备。
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3.发明申请MODIFIED ACTINOMYCIN-BASED NUCLEIC ACID STAINS AND METHODS OF THEIR USE 有权改良的基于ACTINOMYCIN的核酸污染物及其使用方法公开(公告)号：US20110236887A1
公开(公告)日：2011-09-29
申请号：US13126150
申请日：2009-10-26
申请人： Stephen Yue , Jixiang Liu , Jolene Bradford
发明人： Stephen Yue , Jixiang Liu , Jolene Bradford
IPC分类号： C12Q1/68 , G01N33/50 , C07D265/38
CPC分类号： C07D265/38
摘要： Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.
摘要翻译： 提供基于放线菌素的近红外发射化合物及其用作核酸污渍的方法。
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4.发明授权公开(公告)号：US08653261B2
公开(公告)日：2014-02-18
申请号：US13126150
申请日：2009-10-26
申请人： Stephen Yue , Jixiang Liu , Jolene Bradford
发明人： Stephen Yue , Jixiang Liu , Jolene Bradford
IPC分类号： C07D265/38
CPC分类号： C07D265/38
摘要： Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure: wherein R is H or NH2; R1, R2, R3, and R4 are independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; R3 and/or R4 comprise a quaternary nitrogen atom; and R5 is H, F, or Cl.
摘要翻译： 提供了基于放射性肌动蛋白的近红外发射化合物及其用作核酸污渍的方法。 基于放电肌注蛋白的近红外发射化合物具有以下结构：其中R是H或NH 2; R1，R2，R3和R4独立地是包含1-30个选自H，O，C和N的原子的部分，其中原子是直链，支链或环状构型; R3和/或R4包含季氮原子; R5为H，F或Cl。
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公开(公告)号：US20120028249A1
公开(公告)日：2012-02-02
申请号：US13126234
申请日：2009-10-20
申请人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
发明人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
IPC分类号： C12Q1/68 , C07H21/04 , C07D233/61 , C07D403/12 , C07D401/12 , C07D295/13 , C07C255/43 , C07D295/192 , C07D205/04 , C07D207/09
CPC分类号： G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441
摘要： Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
摘要翻译： 近红外发射荧光化合物; 制备方法和含有所述化合物的试剂盒; 以及它们在荧光检测生物材料中的应用。
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公开(公告)号：US08999965B2
公开(公告)日：2015-04-07
申请号：US13126234
申请日：2009-10-20
申请人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
发明人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
CPC分类号： G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441
摘要： Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
摘要翻译： 近红外发射荧光化合物; 制备方法和含有所述化合物的试剂盒; 以及它们在荧光检测生物材料中的应用。
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7.发明授权Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use 有权对双链DNA具有高选择性的荧光化合物及其使用方法公开(公告)号：US07943777B2
公开(公告)日：2011-05-17
申请号：US12573809
申请日：2009-10-05
IPC分类号： C07D417/00 , C07D215/00 , C07D251/38
CPC分类号： G01N33/582 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/6876 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2201/06113 , Y10T436/143333
摘要： Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
摘要翻译： 公开了对RNA和单链DNA具有对双链DNA的高选择性的化合物。 化学化合物是在照射时变成荧光并与双链DNA相互作用的污渍，但在不存在双链DNA的情况下表现出减少的或没有荧光。 该化合物可用于各种生物学应用中，以定性或定量测定DNA，即使在RNA的存在下。
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8.发明申请Flourescent chemical compounds having high selectivity for double standard DNA, and methods for their use 有权对双标准DNA具有高选择性的荧光化合物及其使用方法公开(公告)号：US20060263844A1
公开(公告)日：2006-11-23
申请号：US11432814
申请日：2006-05-11
IPC分类号： C12Q1/02
CPC分类号： G01N33/582 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/6876 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2201/06113 , Y10T436/143333
摘要： Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
摘要翻译： 公开了对RNA和单链DNA具有对双链DNA的高选择性的化合物。 化学化合物是在照射时变成荧光并与双链DNA相互作用的污渍，但在不存在双链DNA的情况下表现出减少的或没有荧光。 该化合物可用于各种生物学应用中，以定性或定量测定DNA，即使在RNA的存在下。
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公开(公告)号：US08669374B2
公开(公告)日：2014-03-11
申请号：US13218395
申请日：2011-08-25
申请人： Gene Shen , Stephen Yue
发明人： Gene Shen , Stephen Yue
IPC分类号： C07D209/02 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6869 , C07D209/14 , C07D401/14 , C07D405/14 , C07H19/10 , C07K5/0815 , C07K5/1019 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/164 , C12Q1/6844 , C12Q1/6876 , G01N33/52 , G01N33/582 , G01N2333/9126
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译： 本发明提供了一种新颖的花青染料，其可用连接体部分官能化，这些连接部分有助于它们与增加水溶性的其它物质和取代基结合，并优化染料的光学性质。 还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。
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公开(公告)号：US08569506B2
公开(公告)日：2013-10-29
申请号：US13556643
申请日：2012-07-24
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： C07D215/00
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
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