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    Process for preparing chiral compounds from recemic epoxides by using chiral salen catalysts
    2.
    发明授权
    Process for preparing chiral compounds from recemic epoxides by using chiral salen catalysts 有权
    通过使用手性盐酸催化剂从接受环氧化物制备手性化合物的方法

    公开(公告)号：US06720434B2

    公开(公告)日：2004-04-13

    申请号：US10181193

    申请日：2002-07-11

    申请人： Geon-Joong Kim ,  Dae-Woon Park ,  Ho Seong Lee ,  Jin Won Yun ,  Seong Jin Kim

    发明人： Geon-Joong Kim ,  Dae-Woon Park ,  Ho Seong Lee ,  Jin Won Yun ,  Seong Jin Kim

    IPC分类号： C07D30104

    CPC分类号： B01J31/2243 ,  B01J2231/487 ,  B01J2531/0252 ,  B01J2531/845 ,  C07B2200/07 ,  C07D301/00 ,  C07F15/065

    摘要： The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide chiral salen catalysts and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis of racemic epoxides, wherein the chiral salen catalyst comprises a cationic cobalt as a center metal of chiral salen ligand and counterions having weak nucleophilic property to resolve disadvantages associated with conventional chiral salen catalysts, and can be used continuously without any activating process of used catalysts because it does not loose a catalytic activity during the reaction process.

    摘要翻译： 本发明涉及手性盐酸催化剂和通过使用它们由外消旋环氧化物制备手性化合物的方法。 更具体地说，本发明是通过进行外消旋环氧化物的立体选择性水解，提供手性盐酸催化剂及其用于以高产率和高光学纯度经济地制备手性环氧化物和手性1,2-二醇的用途，其中手性盐 催化剂包含阳离子钴作为手性salen配体的中心金属和具有弱亲核性质的抗衡离子，以解决与常规手性salen催化剂相关的缺点，并且可以连续使用而不使用所用催化剂的任何活化方法，因为它不会在 反应过程。

    Process for preparing (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid, and (-)-chiral stationary phases for resolution of racemic compounds using the same
    4.
    发明授权
    Process for preparing (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid, and (-)-chiral stationary phases for resolution of racemic compounds using the same 有权
    （ - ） - （18-冠-6）-2,3,11,12-四羧酸和（ - ） - 手性固定相制备用于拆分外消旋化合物的方法

    公开(公告)号：US06818778B2

    公开(公告)日：2004-11-16

    申请号：US10432326

    申请日：2003-05-22

    申请人： Ho Seong Lee ,  Chang Soo Lee ,  Jin Won Yun ,  Seong Jin Kim ,  Kyung-Hyun Gahm

    发明人： Ho Seong Lee ,  Chang Soo Lee ,  Jin Won Yun ,  Seong Jin Kim ,  Kyung-Hyun Gahm

    IPC分类号： C07D32300

    CPC分类号： C07D323/00

    摘要： The present invention relates to a process for preparing (−)-(18-crown-6)-2,3,11,12-tetracarboxylic acid and its use for (−)-chiral stationary phases for resolution of racemic compounds. More particularly, the present invention relates to the process for preparing (−)-(18-crown-6)-2,3,11,12-tetracarboxylic acid expressed by formula (1) and the use thereof as a stationary phases for resolution of racemic compounds, wherein the use of them provides excellent separation of a desired chiral compound from racemic mixture in employing capillary electrophoresis (CE) or liquid chromatography to elute the desired one first by controlling a flowing order of enantioners, thus allowing to be consistently separated in an economical due to much less requirement of eluent, quantitative and high purity manner.

    摘要翻译： 本发明涉及制备（ - ） - （18-冠-6）-2,3,11,12-四羧酸的方法及其用于（ - ） - 手性固定相以拆分外消旋化合物的方法。 更具体地说，本发明涉及由式（1）表示的（ - ） - （18-冠-6）-2,3,11,12-四羧酸的制备方法及其作为用于分辨的固定相的用途 的外消旋化合物，其中使用它们在使用毛细管电泳（CE）或液相色谱法中从外消旋混合物中提供优异的分离，以首先通过控制对映体的流动顺序洗脱所需的手性化合物，从而允许一致地分离 由于洗脱液要求少，定量和高纯度的方式经济。

    Process for the Preparation of N(5)-Ethylglutamine
    5.
    发明申请
    Process for the Preparation of N(5)-Ethylglutamine 审中-公开
    制备N（5） - 乙基谷氨酰胺的方法

    公开(公告)号：US20080234508A1

    公开(公告)日：2008-09-25

    申请号：US11914174

    申请日：2006-05-18

    申请人： Ho Seong Lee ,  Jeong Ho Song ,  Ho Cheol Kim

    发明人： Ho Seong Lee ,  Jeong Ho Song ,  Ho Cheol Kim

    IPC分类号： C07C237/06 ,  C07C235/84

    CPC分类号： C07C237/22 ,  C07C231/14 ,  C07C233/83 ,  C07C237/06

    摘要： Disclosed relates to a process for preparing N(5)-ethylglutamines economically without a specific purification process via a simplified and safe process, in which glutamic acid derivatives, represented by formula 1, protected by phthaloyl groups react with ethylamine to cause an amidation and a deprotection reaction in turn under the same reaction condition, thus preparing N(5)-ethylglutamines.

    摘要翻译： 本发明涉及经由简化和安全的方法经济地制备N（5） - 乙基谷氨酰胺的方法，其中由邻苯二甲酰基保护的由式1表示的谷氨酸衍生物与乙胺反应以产生酰胺化和 在相同的反应条件下依次进行脱保护反应，从而制备N（5） - 乙基谷氨酰胺。

    Method of preparing fluoroaromatic compounds
    6.
    发明授权
    Method of preparing fluoroaromatic compounds 有权
    氟代芳族化合物的制备方法

    公开(公告)号：US6008407A

    公开(公告)日：1999-12-28

    申请号：US185171

    申请日：1998-11-03

    申请人： Oleg Matveyevich Nefedov ,  Nikolay Vasiljcvich Volchkov ,  Mariya Borisovna Lipkind ,  Ho Seong Lee ,  Young Jun Park ,  Min Hwan Kim

    发明人： Oleg Matveyevich Nefedov ,  Nikolay Vasiljcvich Volchkov ,  Mariya Borisovna Lipkind ,  Ho Seong Lee ,  Young Jun Park ,  Min Hwan Kim

    IPC分类号： C07C17/25 ,  C07C17/30 ,  C07C25/13 ,  C07C51/58 ,  C07C51/16

    CPC分类号： C07C17/30 ,  C07C17/25 ,  C07C25/13 ,  C07C51/093 ,  C07C51/58

    摘要： The present invention provides a method of preparing ortho-difluorobenzene derivatives, which comprises (a) providing a mixture of cyclohexenes by reacting chlorotrifluoroethylene (CTFE) and 1.3-diene in a flow reactor and distilling the resultant, and (b) dehydrohalogenating the mixture of cyclohexenes with a phase transition catalyst in :he presence of alkali metal hydroxide at temperature range of 40 to 150.degree. C. without using any organic solvent. The distillate having low boiling point, which is obtained during distillation of the resultant, is recycled into the flow reactor. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoic acid, which comprises (a) providing a mixture of 4-chloro-1-methyl-4,5,5-trifluorocyclohexene and 5-chloro-1-methyl-4,4,5-trifluorocyclohexene by reacting chlorotrifluoroethylene (CTFE) and isoprene and distilling the resultant. (b) dehydrohalogenating said mixture in the presence of alkali metal hydroxide and a phase transition catalyst to form 3,4-difluorotoluene, to reacting said 3,4-difluorotoluene with chlorine gas without using any organic solvent to form 2-chloro-4,5-difluorotoluene, (d) photo-reacting said 2-chloro-4,5-difluorotoluene with chlorine gas under a lighting mercury lamp without using any organic solvent to form 2-chloro-4,5-difluorobenzotrichloride, and (e) reacting said 2-chloro-4,5-difluorobenzotrichloride with aqueous acid solution without using any organic solvent. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoyl chloride by reacting the 2-chloro-4,5-difluorobenzotrichloride of step (e) above with zinc oxide.

    摘要翻译： 本发明提供了一种制备邻二氟苯衍生物的方法，其包括（a）通过在流动反应器中使氯三氟乙烯（CTFE）和1,3-二烯反应提供环己烯的混合物并蒸馏所得物，和（b）脱卤化氢 具有相变催化剂的环己烯：在不使用任何有机溶剂的情况下，在40至150℃的温度范围内存在碱金属氢氧化物。 在蒸馏过程中获得的具有低沸点的馏出物被循环到流动反应器中。 本发明还提供了制备2-氯-4,5-二氟苯甲酸的方法，其包括（a）提供4-氯-1-甲基-4,5,5-三氟环己烯和5-氯-1 - 甲基-4,4,5-三氟环己烯，通过氯三氟乙烯（CTFE）和异戊二烯反应并蒸馏所得物。 （b）在碱金属氢氧化物和相变催化剂的存在下将所述混合物脱卤化氢以形成3,4-二氟甲苯，使所述3,4-二氟甲苯与氯气反应，而不使用任何有机溶剂形成2-氯-4， （d）在照明汞灯下使所述2-氯-4,5-二氟甲苯与氯气进行光反应，而不使用任何有机溶剂形成2-氯-4,5-二氟三氯甲苯，和（e）使 所述2-氯-4,5-二氟三氯甲烷与含水酸溶液不使用任何有机溶剂。 本发明还提供通过使上述步骤（e）的2-氯-4,5-二氟三氯甲苯与氧化锌反应来制备2-氯-4,5-二氟苯甲酰氯的方法。

    IMAGE SENSOR WITH SHAKING COMPENSATION
    8.
    发明申请
    IMAGE SENSOR WITH SHAKING COMPENSATION 审中-公开
    具有SHAKING补偿的图像传感器

    公开(公告)号：US20110109752A1

    公开(公告)日：2011-05-12

    申请号：US12616583

    申请日：2009-11-11

    申请人： Ho Seong Lee

    发明人： Ho Seong Lee

    IPC分类号： H04N5/228

    CPC分类号： H04N5/23248 ,  H04N5/23254 ,  H04N5/345

    摘要： A camera includes a main pixel array, one or more shaking detection pixel groups, and logic circuitry. The main pixel array can generate image frames of an image at an image frame rate. The one or more shaking detection pixel groups can generate shaking detection data where one or more pixels of the first shaking detection pixel group are sampled at a rate that is faster than the image frame rate. The logic circuitry can evaluate the shaking detection data to select a frame of the generated image frames after receiving a picture taking signal.

    摘要翻译： 相机包括主像素阵列，一个或多个抖动检测像素组和逻辑电路。 主像素阵列可以以图像帧速率生成图像的图像帧。 一个或多个抖动检测像素组可以产生其中以比图像帧速率更快的速率对第一抖动检测像素组的一个或多个像素进行采样的抖动检测数据。 逻辑电路可以在接收到拍摄信号之后评估摇动检测数据以选择所生成的图像帧的帧。

    CHIRAL SALEN CATALYSTS AND METHODS FOR THE PREPARATION OF CHIRAL COMPOUNDS FROM RACEMIC EPOXIDES BY USING THEM
    10.
    发明申请
    CHIRAL SALEN CATALYSTS AND METHODS FOR THE PREPARATION OF CHIRAL COMPOUNDS FROM RACEMIC EPOXIDES BY USING THEM 审中-公开
    CHALAL SALEN催化剂和使用它们从环氧化合物制备化合物的方法

    公开(公告)号：US20100087662A1

    公开(公告)日：2010-04-08

    申请号：US12522058

    申请日：2008-05-23

    申请人： Ho Seong Lee

    发明人： Ho Seong Lee

    IPC分类号： C07D327/10 ,  C07F17/00 ,  C07D301/27 ,  C07C31/20

    CPC分类号： C07F15/065 ,  Y02P20/584

    摘要： The present invention relates to new chiral salen catalysts and the preparation method of chiral compounds from racemic epoxides using the same. More specifically, it relates to new chiral salen catalysts that have high catalytic activity due to new molecular structures and have no or little racemization of the generated target chiral compounds even after the reaction is completed and can be also reused without catalyst regeneration treatment, and its economical preparation method to mass manufacture chiral compounds of high optical purity, which can be used as raw materials for chiral food additives, chiral drugs, or chiral crop protection agents, etc., using the new chiral salen catalysts.

    摘要翻译： 本发明涉及新的手性盐酸催化剂和使用其的外消旋环氧化物的手性化合物的制备方法。 更具体地说，涉及由于新的分子结构而具有高催化活性的新型手性盐酸催化剂，即使在反应完成后也不会产生目标手性化合物的外消旋化，也可在不进行催化剂再生处理的情况下重复使用， 大量制备高光学纯度的手性化合物的经济制备方法，其可以用作手性食品添加剂的原料，手性药物或手性作物保护剂等，使用新的手性盐酸催化剂。