INTEGRATED THIN-FILM OPTRODE
    2.
    发明申请
    INTEGRATED THIN-FILM OPTRODE 有权
    集成薄膜光口

    公开(公告)号:US20140350375A1

    公开(公告)日:2014-11-27

    申请号:US14287760

    申请日:2014-05-27

    摘要: An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer.

    摘要翻译: 光电可以提供圆柱形衬底,两个或多个电极沉积所述圆柱形衬底。 圆柱形基底和电极可以通过绝缘层涂覆,该绝缘层具有在电极的某些部分上的开口或通孔,其可以为神经探针提供接触,或者可以用于连接导线。 光栅的制造可以利用固定由导电材料和抗蚀剂涂覆的圆柱形基底的夹具。 可以将第一掩模定位在由夹具提供的开口中,并且圆柱形基底可以是暴露的离子或中性粒子以限定一个或多个电极图案。 在去除抗蚀剂和导电材料的区域以形成电极之后,可以使用第二掩模来限定通孔区域,其中电极的部分被绝缘层暴露和未涂覆。

    Raman spectroscopy for non-invasive glucose measurements
    5.
    发明授权
    Raman spectroscopy for non-invasive glucose measurements 有权
    用于非侵入性葡萄糖测量的拉曼光谱

    公开(公告)号:US08355767B2

    公开(公告)日:2013-01-15

    申请号:US11412418

    申请日:2006-04-27

    IPC分类号: A61B5/1455

    摘要: The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

    摘要翻译: 本发明涉及拉曼光谱法用于定量,非侵入性经皮测量血液分析物如葡萄糖的用途。 在监测血糖水平的患者中,拉曼光谱法用于经皮测量葡萄糖。 通过标准毛细管血液分析提供的葡萄糖参考值,经皮收集拉曼光谱。 从每个受试者的数据创建偏最小二乘法校准,并使用离开一对交叉验证进行验证。

    Intrinsic Raman spectroscopy
    8.
    发明授权
    Intrinsic Raman spectroscopy 有权
    内在拉曼光谱

    公开(公告)号:US09103793B2

    公开(公告)日:2015-08-11

    申请号:US11492214

    申请日:2006-07-24

    摘要: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

    摘要翻译: 本发明涉及用于测量诸如葡萄糖的分析物的系统和方法。 使用拉曼和反射光谱来测量受试者内的材料,例如血液样本或组织的体积,并且基于此测定血液分析物的浓度。 本发明还涉及校准方法,约束正则化(CR),并证明其用于分析光谱的用途,包括例如使用经皮拉曼光谱测量葡萄糖浓度。

    Intrinsic Raman spectroscopy
    10.
    发明申请
    Intrinsic Raman spectroscopy 有权
    内在拉曼光谱

    公开(公告)号:US20070049809A1

    公开(公告)日:2007-03-01

    申请号:US11492214

    申请日:2006-07-24

    IPC分类号: A61B5/00

    摘要: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

    摘要翻译: 本发明涉及用于测量诸如葡萄糖的分析物的系统和方法。 使用拉曼和反射光谱来测量受试者内的材料,例如血液样本或组织的体积,并且基于此测定血液分析物的浓度。 本发明还涉及校准方法,约束正则化(CR),并证明其用于分析光谱的用途,包括例如使用经皮拉曼光谱测量葡萄糖浓度。