利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

34 条记录 (耗时 0.034 秒)

    Collagen-thrombin compositions
    5.
    发明授权
    Collagen-thrombin compositions 失效
    胶原凝血酶组合物

    公开(公告)号：US4515637A

    公开(公告)日：1985-05-07

    申请号：US552110

    申请日：1983-11-16

    申请人： Gheorghe Cioca

    发明人： Gheorghe Cioca

    IPC分类号： A61K38/17 ,  A61K38/48 ,  A61L15/32 ,  A61L15/42 ,  A61L15/64 ,  C08L89/06 ,  A61K35/14 ,  C08H1/06

    CPC分类号： A61L15/64 ,  A61L15/325 ,  A61L15/425 ,  C08L89/06 ,  A61L2400/04 ,  Y10S514/801

    摘要： A method of forming a collagen-thrombin hemostatic composition is comprised of forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH and lyophilizing the collagen-thrombin admixture to form a stable collagen sponge having thrombin therein. The collagen utilized in the process is absorbable when placed in vivo. Additionally, a lyophilized collagen product is comprised of collagen which is absorbable when placed in vivo and thrombin distributed within the collagen. The collagen product is storage stable.

    摘要翻译： 形成胶原凝血酶止血组合物的方法包括在碱性pH下形成均匀的胶原蛋白和凝血酶水溶性混合物，并将胶原凝血酶外加剂冻干以形成其中具有凝血酶的稳定的胶原海绵。 在体内使用的胶原蛋白是可吸收的。 此外，冻干胶原蛋白产品由胶原蛋白组成，胶原蛋白在体内放置时可吸收，凝血酶分布于胶原蛋白内。 胶原蛋白产品储存稳定。

    Process for preparing macromolecular biologically active collagen
    6.
    发明授权
    Process for preparing macromolecular biologically active collagen 失效
    制备大分子生物活性胶原蛋白的方法

    公开(公告)号：US4279812A

    公开(公告)日：1981-07-21

    申请号：US74738

    申请日：1979-09-12

    申请人： Gheorghe Cioca

    发明人： Gheorghe Cioca

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/70 ,  A61K47/42 ,  A61L15/32 ,  A61L15/44 ,  A61L26/00 ,  C07K14/78 ,  C08L89/06 ,  C14C1/00 ,  C07G7/00

    CPC分类号： C08L89/06 ,  A61K9/70 ,  A61L15/325 ,  A61L15/44 ,  A61L26/0033 ,  A61L2300/404 ,  A61L2300/43 ,  Y10S128/08

    摘要： Macromolecular reconstituted collagen is prepared by treating natural insoluble collagen with an aqueous solution comprised of an alkali sulfate salt and an alkali metal hydroxide for at least 48 hours to saponify fats suspended within the natural insoluble collagen. The fat free collagen is then treated with an aqueous solution comprised of an alkali metal sulfate for at least four hours to stabilize the interfibular bonds between individual polypeptide chains. The collagen is then dissolved in an aqueous acid solution and frozen at a rate of -20.degree. C./hour. The frozen collagen is vacuum dried at 10.sup.-3 to 10.sup.-5 torr for at least 16 hours to produce a biologically active collagen article. Various biologically active materials may be added to the aqueous acid solution prior to freezing. The collagen product may then be implanted into an animal or the like and the medication slowly released. The article can remain within the biological system and it will slowly dissolve due to enzymatic digestion and through other biological processes.

    摘要翻译： 通过用含有碱金属硫酸盐和碱金属氢氧化物的水溶液处理天然不溶性胶原蛋白至少48小时以皂化悬浮在天然不溶性胶原蛋白中的脂肪来制备大分子复原胶原蛋白。 然后用含有碱金属硫酸盐的水溶液处理不含脂肪的胶原蛋白至少4小时以稳定各个多肽链之间的界面结合。 然后将胶原溶解在酸性水溶液中，并以-20℃/小时的速度冷冻。 将冷冻的胶原蛋白在10-3至10-5乇真空干燥至少16小时以产生生物活性胶原物品。 在冷冻之前，可以向酸性水溶液中加入各种生物活性物质。 然后将胶原产品植入动物等中，药物缓慢释放。 该物品可以保留在生物系统内，并且由于酶消化和通过其他生物过程而将缓慢溶解。

    Cosmetic compositions containing fluorescent minerals
    7.
    发明授权
    Cosmetic compositions containing fluorescent minerals 有权
    包含荧光矿物的化妆品组合物

    公开(公告)号：US06753002B2

    公开(公告)日：2004-06-22

    申请号：US10391367

    申请日：2003-03-18

    申请人： Liliana George ,  Joseph Gubernick ,  Gheorghe Cioca ,  Andrew J. Bevacqua

    发明人： Liliana George ,  Joseph Gubernick ,  Gheorghe Cioca ,  Andrew J. Bevacqua

    IPC分类号： A61K700

    CPC分类号： A61Q1/08 ,  A61K8/26 ,  A61K2800/434 ,  A61Q1/02

    摘要： The invention relates to cosmetic composition comprising a fluorescent-effective amount of at least one fluorescent mineral powder, in combination with a cosmetically acceptable vehicle, wherein the powder, when the composition is applied, does not substantially alter the color of the skin. The compositions of the invention can be used as color cosmetics and skin treatment products, to replenish the skin's natural fluorescent glow.

    摘要翻译： 本发明涉及包含荧光有效量的至少一种荧光矿物粉末与化妆品可接受的载体的化妆品组合物，其中当施用组合物时，粉末基本上不改变皮肤的颜色。 本发明的组合物可用作彩色化妆品和皮肤处理产品，以补充皮肤的天然荧光发光。