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    MICROFLUIDIC, ELECTROCHEMICAL DEVICES
    1.
    发明申请
    MICROFLUIDIC, ELECTROCHEMICAL DEVICES 有权
    微电子，电化学设备

    公开(公告)号：US20120181184A1

    公开(公告)日：2012-07-19

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  G01N27/416

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。

    Microfluidic, electrochemical devices
    2.
    发明授权
    Microfluidic, electrochemical devices 有权
    微流控，电化学装置

    公开(公告)号：US09192933B2

    公开(公告)日：2015-11-24

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  B01L3/00 ,  G01N27/327

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。

    Self-regulating pressure source
    5.
    发明授权
    Self-regulating pressure source 有权
    自调压源

    公开(公告)号：US09027336B2

    公开(公告)日：2015-05-12

    申请号：US13420886

    申请日：2012-03-15

    申请人： Cagdas Denizel Onal ,  Daniela Rus ,  Xin Chen ,  George M. Whitesides

    发明人： Cagdas Denizel Onal ,  Daniela Rus ,  Xin Chen ,  George M. Whitesides

    IPC分类号： F16D31/02 ,  G05D16/06 ,  F15B21/06

    CPC分类号： G05D16/0636 ,  F15B21/06

    摘要： Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

    摘要翻译： 自调压源。 压力源包括封闭化学单元推进剂的室。 可移动的凸台连接到密封空气室的可变形膜，可移动的凸台和空气室设置在室内。 催化剂设置在膜周围，以便被凸起覆盖在缩回位置，使得单组分推进剂被催化剂分解以产生气体。 在室内气体压力将增加，导致空气室中的空气压缩，从而将凸台拉到缩回位置以覆盖催化剂，从而调节室内的压力。 自调节压力源特别适用于流体弹性致动器。

    SELF-REGULATING PRESSURE SOURCE
    6.
    发明申请
    SELF-REGULATING PRESSURE SOURCE 有权
    自调压源

    公开(公告)号：US20120272642A1

    公开(公告)日：2012-11-01

    申请号：US13420886

    申请日：2012-03-15

    申请人： Cagdas Denizel Onal ,  Daniela Rus ,  Xin Chen ,  George M. Whitesides

    发明人： Cagdas Denizel Onal ,  Daniela Rus ,  Xin Chen ,  George M. Whitesides

    IPC分类号： F15B13/16 ,  B01J19/00

    CPC分类号： G05D16/0636 ,  F15B21/06

    摘要： Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

    摘要翻译： 自调压源。 压力源包括封闭化学单元推进剂的室。 可移动的凸台连接到密封空气室的可变形膜，可移动的凸台和空气室设置在室内。 催化剂设置在膜周围，以便被凸起覆盖在缩回位置，使得单组分推进剂被催化剂分解以产生气体。 在室内气体压力将增加，导致空气室中的空气压缩，从而将凸台拉到缩回位置以覆盖催化剂，从而调节室内的压力。 自调节压力源特别适用于流体弹性致动器。

    Synchronization method and system for single event list type data in PET imaging
    8.
    发明授权
    Synchronization method and system for single event list type data in PET imaging 有权

    公开(公告)号：US10930031B2

    公开(公告)日：2021-02-23

    申请号：US14408935

    申请日：2012-08-14

    申请人： Qingguo Xie ,  Yuanbao Chen ,  Jun Zhu ,  Xin Chen ,  Zhongyi Wu ,  Luyao Wang

    发明人： Qingguo Xie ,  Yuanbao Chen ,  Jun Zhu ,  Xin Chen ,  Zhongyi Wu ,  Luyao Wang

    IPC分类号： G06T11/00 ,  G01T1/29 ,  A61B6/03

    摘要： A method for synchronizing list-mode data of single events in a PET imaging includes: acquiring list-mode data of single events of each independent detector module, calculating a probability density of time intervals between occurrences of single events in detector module and setting initial parameters, determining detection starting time difference of each detector module with iterative peak searching and graded time window, and performing synchronization correction and coincidence discrimination on the single event data in each detector module based on the detection starting time difference. A system for synchronizing list-mode data of single events in a PET imaging includes: a data acquisition and frequency difference compensation module, an initial parameter setting module, a coarse time scale coincidence module, a fine time scale coincidence module and a data synchronization correction and coincidence discrimination module.

    Measuring tissue shear wave properties using one excitation pulse and excitation pulses having different widths and shapes
    10.
    发明授权
    Measuring tissue shear wave properties using one excitation pulse and excitation pulses having different widths and shapes 有权

    公开(公告)号：US10327739B2

    公开(公告)日：2019-06-25

    申请号：US15090357

    申请日：2016-04-04

    申请人： Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    发明人： Yi Zheng ,  Siping Chen ,  Tianfu Wang ,  Xin Chen ,  Haoming Lin

    IPC分类号： A61B8/08 ,  G01S7/52 ,  G01S7/62

    摘要： Ultrasound radiation using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties including nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity.