Bacteriophage T4 Nanoparticles for Eukaryotic Delivery
    9.
    发明申请
    Bacteriophage T4 Nanoparticles for Eukaryotic Delivery 审中-公开
    噬菌体T4纳米颗粒用于真核递送

    公开(公告)号:US20120214867A1

    公开(公告)日:2012-08-23

    申请号:US13396110

    申请日:2012-02-14

    摘要: A T4 nanoparticle is a non-infectious, tail-less variant of a T4 bacteriophage. In one embodiment, eukaryotic cells are labeled with dyed T4 nanoparticles, wherein each dyed T4 nanoparticle comprises at least 350 dye molecules covalently bound thereto. In another embodiment, T4 nanoparticles are used to deliver exogenous DNA to eukaryotic cells for protein expression therein. It is contemplated that T4 nanoparticles may be used to deliver other exogenous material to eukaryotic cells.

    摘要翻译: T4纳米颗粒是T4噬菌体的无感染,无尾的变体。 在一个实施方案中,用染色的T4纳米颗粒标记真核细胞,其中每个染色的T4纳米颗粒包含至少350个与其共价结合的染料分子。 在另一个实施方案中,使用T4纳米颗粒将外源DNA递送到真核细胞中用于蛋白质表达。 预期T4纳米颗粒可用于将其它外源材料递送至真核细胞。