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公开(公告)号：US20050032913A1
公开(公告)日：2005-02-10
申请号：US10637149
申请日：2003-08-08
摘要： A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol.
摘要翻译： 用朊病毒污染的表面或液体去污的方法包括用包含一种或多种苯酚的组合物处理表面。 特别有效的酚包括对氯 - 间 - 木聚糖，百里酚，三氯生，4-氯，3-甲基苯酚，五氯苯酚，六氯酚，2,2-甲基 - 双（4-氯苯酚）和对苯基苯酚。
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公开(公告)号：US20050256018A1
公开(公告)日：2005-11-17
申请号：US10843600
申请日：2004-05-11
申请人： Shahin Keller , Herbert Kaiser , Jason Tirey , Daniel Klein , Nancy E. Kaiser
发明人： Shahin Keller , Herbert Kaiser , Jason Tirey , Daniel Klein , Nancy E. Kaiser
CPC分类号： C11D3/48 , A01N31/08 , C11D3/2006 , C11D3/2034 , C11D3/2041 , C11D3/2075 , A01N41/04 , A01N31/02 , A01N37/02 , A01N37/36 , A01N2300/00
摘要： A low pH disinfectant composition comprises an aqueous composition of a phenolic compound, an organic acid, and/or a dispersing surfactant and/or solvent. The disinfectant solution can be concentrated, or more preferably diluted ready to use, and is very effective in eradicating fungi including Aspergillus niger.
摘要翻译： 低pH消毒剂组合物包含酚类化合物，有机酸和/或分散表面活性剂和/或溶剂的水性组合物。 可以将消毒剂溶液浓缩，或更优选稀释即可使用，并且对根除真菌（包括黑曲霉）非常有效。
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公开(公告)号：US20120264673A1
公开(公告)日：2012-10-18
申请号：US13066362
申请日：2011-04-13
申请人： Shahin Keller , Nancy E. Kaiser
发明人： Shahin Keller , Nancy E. Kaiser
CPC分类号： C11D11/0041 , C11D3/2068 , C11D3/2093 , C11D3/43 , C11D7/5013 , C11D7/5022
摘要： A solvent blend cleaner useful for reflux cleaning of chemical manufacturing equipment, including that used in manufacturing pharmaceuticals, comprises a blend of environmentally friendly and safe solvents selected on the basis of specific criteria, such as vapor pressure, vapor density, boiling point, specific heat, and heat of vaporization, among other things; achieves excellent cleaning even upon further dilution with water; and avoids the disadvantages associated with the use of conventional commodity solvents in reflux cleaning methods. Desired solvency, cleaning and wetting properties of the inventive formulations in use can be achieved through blending of solvents having the selected criteria. Additives, such as surfactants, can be added to enhance cleaning and lower solvent requirements.
摘要翻译： 用于化学制造设备的回流清洗的溶剂混合物清洁剂，包括用于制造药物的溶剂混合物清洁剂包括基于特定标准（例如蒸气压，蒸气密度，沸点，比热）选择的环保和安全溶剂的混合物 ，蒸发热等等; 即使进一步用水稀释即可实现极好的清洁; 并避免了在回流清洗方法中使用常规商品溶剂的缺点。 可以通过混合具有所选标准的溶剂来实现所使用的本发明制剂的期望的溶解能力，清洁和润湿性能。 可以添加添加剂，如表面活性剂，以增强清洗和降低溶剂的需求。
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公开(公告)号：US07144846B2
公开(公告)日：2006-12-05
申请号：US10843600
申请日：2004-05-11
CPC分类号： C11D3/48 , A01N31/08 , C11D3/2006 , C11D3/2034 , C11D3/2041 , C11D3/2075 , A01N41/04 , A01N31/02 , A01N37/02 , A01N37/36 , A01N2300/00
摘要： A low pH disinfectant composition comprises an aqueous composition of a phenolic compound, an organic acid, and/or a dispersing surfactant and/or solvent. The disinfectant solution can be concentrated, or more preferably diluted ready to use, and is very effective in eradicating fungi including Aspergillus niger.
摘要翻译： 低pH消毒剂组合物包含酚类化合物，有机酸和/或分散表面活性剂和/或溶剂的水性组合物。 可以将消毒剂溶液浓缩，或更优选稀释即可使用，并且对根除真菌（包括黑曲霉）非常有效。
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5.发明申请公开(公告)号：US20080221006A1
公开(公告)日：2008-09-11
申请号：US11715695
申请日：2007-03-08
申请人： Christopher C. Heisig , Shahin Keller , John Macauley , Gurusamy Manivannan , Daniel Klein , Michael Ebers
发明人： Christopher C. Heisig , Shahin Keller , John Macauley , Gurusamy Manivannan , Daniel Klein , Michael Ebers
IPC分类号： C11D3/20
摘要： An aqueous, alkaline cleaning composition for use on hard-to-clean soils, encountered in pharmaceutical, personal care, food and cosmetic manufacturing, comprising a source of alkalinity, a biodegradable surfactant system further comprising one or more surfactants, one or more hydrotropes, and a UV-analyzable surfactant, and a biodegradable chelating agent. The composition offers unique advantages of stability over the expected shelf life, low-foaming property, phosphate-free and biodegradable components, and unexpectedly enhanced antimicrobial, including virucidal, activity in one cleaning composition. The UV-analyzable surfactant allows for validation of cleaning processes using known techniques for manufacturers who are required or desire to do so.
摘要翻译： 一种用于制药，个人护理，食品和化妆品制造中难以清洁的污垢的水性碱性清洁组合物，其包含碱性源，还包含一种或多种表面活性剂的一种可生物降解的表面活性剂体系，一种或多种水溶助长剂， 和可UV分析的表面活性剂和可生物降解的螯合剂。 该组合物提供了在预期的保质期，低起泡性，无磷酸盐和可生物降解的组分中的稳定性的独特优点，以及意想不到的增强的抗微生物剂，包括一种清洁组合物中的杀病毒活性。 UV可分析的表面活性剂允许使用已知技术对需要或希望的制造商进行清洁过程的验证。
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公开(公告)号：US06387858B1
公开(公告)日：2002-05-14
申请号：US09540950
申请日：2000-03-31
IPC分类号： C11D337
CPC分类号： C11D3/222 , C11D3/3765 , C11D11/0058 , C11D17/003
摘要： A method for treating medical instruments after a surgical procedure, which leaves blood or other body fluid on the instrument, includes applying a gel composition that inhibits the fluid from drying on the instruments. The gel composition is preferably a low viscosity gel exhibiting both sufficient flow and coating characteristics. The viscosity is preferably from about 700 to about 4,000 centipoise (cps), preferably around 3,000 cps. Applying a gel to post-surgical medical instruments contains and keeps protein containing fluids moist for extended periods of time and facilitates subsequent transportation, cleaning, and sterilization of such instruments.
摘要翻译： 用于在外科手术之后治疗医疗器械的方法，其将仪器上的血液或其他体液包括在凝胶组合物上，该凝胶组合物抑制流体在仪器上干燥。 凝胶组合物优选是表现出足够的流动性和涂层特性的低粘度凝胶。 粘度优选为约700至约4,000厘泊（cps），优选约3,000cps。 在手术后的医疗仪器上使用凝胶含有并保持含蛋白质的液体长时间潮湿，并有助于此类仪器的后续运输，清洁和灭菌。
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公开(公告)号：US06232280B1
公开(公告)日：2001-05-15
申请号：US09310421
申请日：1999-05-12
申请人： Sayed Sadiq Shah , Herb J. Kaiser , Shahin Keller
发明人： Sayed Sadiq Shah , Herb J. Kaiser , Shahin Keller
IPC分类号： C11D348
CPC分类号： C11D3/044 , C11D1/22 , C11D1/345 , C11D3/0026
摘要： A cleaning composition includes a detectable substance which is relatively stable in the cleaning composition, for indicating whether the cleaning composition has been thoroughly removed from a vessel following a cleaning process. For pharmaceutical applications, the detectable substance is preferably a low-foaming surfactant that is detectable by high performance liquid chromatography at concentrations of around 10 ppm, or less. The surfactant is thus detectable in the same analytical procedure as are traces of pharmaceutical residues which have not been removed from the vessel. The analytical procedure is used to develop a cleaning protocol for future cleaning processes by determining the number of rinses needed for reducing the surfactant, and hence the cleaning product, and also the pharmaceutical residues, in the rinse water to predetermined acceptable levels.
摘要翻译： 清洁组合物包括在清洁组合物中相对稳定的可检测物质，用于指示在清洁过程之后清洁组合物是否已经从容器中彻底移除。 对于药物应用，可检测物质优选是可以通过高浓度约10ppm或更低浓度的高效液相色谱检测的低发泡表面活性剂。 因此在与尚未从容器中除去的药物残留物的痕迹相同的分析程序中可以检测表面活性剂。 分析程序用于通过确定将漂洗水中的表面活性剂和清洁产品以及药物残余物还原到预定的可接受水平所需的漂洗次数来开发用于未来清洁过程的清洁方案。
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8.发明授权公开(公告)号：US07838485B2
公开(公告)日：2010-11-23
申请号：US11715695
申请日：2007-03-08
申请人： Christopher C. Heisig , Shahin Keller , John Macauley , Gurusamy Manivannan , Daniel Klein , Michael Ebers
发明人： Christopher C. Heisig , Shahin Keller , John Macauley , Gurusamy Manivannan , Daniel Klein , Michael Ebers
摘要： An aqueous, alkaline cleaning composition for use on hard-to-clean soils, encountered in pharmaceutical, personal care, food and cosmetic manufacturing, comprising a source of alkalinity, a biodegradable surfactant system further comprising one or more surfactants, one or more hydrotropes, and a UV-analyzable surfactant, and a biodegradable chelating agent. The composition offers unique advantages of stability over the expected shelf life, low-foaming property, phosphate-free and biodegradable components, and unexpectedly enhanced antimicrobial, including virucidal, activity in one cleaning composition. The UV-analyzable surfactant allows for validation of cleaning processes using known techniques for manufacturers who are required or desire to do so.
摘要翻译： 一种用于制药，个人护理，食品和化妆品制造中难以清洁的污垢的水性碱性清洁组合物，其包含碱性源，还包含一种或多种表面活性剂的一种可生物降解的表面活性剂体系，一种或多种水溶助长剂， 和可UV分析的表面活性剂和可生物降解的螯合剂。 该组合物提供了在预期的保质期，低起泡性，无磷酸盐和可生物降解的组分中的稳定性的独特优点，以及意想不到的增强的抗微生物剂，包括一种清洁组合物中的杀病毒活性。 UV可分析的表面活性剂允许使用已知技术对需要或希望的制造商进行清洁过程的验证。
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公开(公告)号：US06632290B1
公开(公告)日：2003-10-14
申请号：US09658126
申请日：2000-09-08
申请人： Sayed Sadiq Shah , Herb J. Kaiser , Shahin Keller
发明人： Sayed Sadiq Shah , Herb J. Kaiser , Shahin Keller
IPC分类号： B08B704
CPC分类号： C11D3/044 , C11D1/22 , C11D1/345 , C11D3/0026
摘要： A cleaning composition includes a detectable substance which is relatively stable in the cleaning composition, for indicating whether the cleaning composition has been thoroughly removed from a vessel following a cleaning process. For pharmaceutical applications, the detectable substance is preferably a low-foaming surfactant that is detectable by high performance liquid chromatography at concentrations of around 10 ppm, or less. The surfactant is thus detectable in the same analytical procedure as are traces of pharmaceutical residues which have not been removed from the vessel. The analytical procedure is used to develop a cleaning protocol for future cleaning processes by determining the number of rinses needed for reducing the surfactant, and hence the cleaning product, and also the pharmaceutical residues, in the rinse water to predetermined acceptable levels.
摘要翻译： 清洁组合物包括在清洁组合物中相对稳定的可检测物质，用于指示在清洁过程之后清洁组合物是否已经从容器中彻底移除。 对于药物应用，可检测物质优选是可以通过高浓度约10ppm或更低浓度的高效液相色谱检测的低发泡表面活性剂。 因此在与尚未从容器中除去的药物残留物的痕迹相同的分析程序中可以检测表面活性剂。 分析程序用于通过确定将漂洗水中的表面活性剂和清洁产品以及药物残留物减少到预定的可接受水平所需的冲洗次数来开发清洁方法，以用于未来的清洁过程。
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