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1.发明申请Medical Devices, Drug Coatings And Methods For Maintaining The Drug Coatings Thereon 审中-公开医疗器械，药物涂层和维护药物涂层的方法公开(公告)号：US20100285089A1
公开(公告)日：2010-11-11
申请号：US12839918
申请日：2010-07-20
IPC分类号： A61F2/82 , A61K31/436 , A61P9/00
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In particular, disclosed herein is a drug delivery device comprising a balloon-expandable intraluminal stent, and a pharmaceutical agent-containing coating, wherein the coating comprises a biocompatible polyfluoro copolymer that comprises about eighty-five weight percent vinylidinefluoride copolymerized with about fifteen weight percent hexafluoropropylene and a pharmaceutical agent intermixed with said polyfluoro copolymer.
摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 特别地，本文公开了一种药物递送装置，其包括球囊可扩张的管腔内支架和含药剂的涂层，其中所述涂层包含生物相容性多氟共聚物，其包含与约十五重量％六氟丙烯共聚的约八十五重量％的偏二氟乙烯 和与所述多氟共聚物混合的药剂。
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公开(公告)号：US07591844B2
公开(公告)日：2009-09-22
申请号：US11941351
申请日：2007-11-16
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61L31/16 , A61L2300/00 , A61L2300/41 , A61L2300/416 , A61L2300/606 , B05D3/0254 , Y10T428/3154 , C08L27/12 , C08L27/16 , C08L27/14
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
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公开(公告)号：US07056550B2
公开(公告)日：2006-06-06
申请号：US10636435
申请日：2003-08-07
申请人： Luis A. Davila , David Christian Lentz , Gerard H. Llanos , Jorge Orlando Mendez , Pallassana V. Narayanan , Alan Roy Pelton , Mark B. Roller , Karl K. Scheidt , Angelo George Scopelianos , William Douglas Shaw, Jr. , James H. Silver , John Spaltro , Christine Trepanier , David J. Wilson
发明人： Luis A. Davila , David Christian Lentz , Gerard H. Llanos , Jorge Orlando Mendez , Pallassana V. Narayanan , Alan Roy Pelton , Mark B. Roller , Karl K. Scheidt , Angelo George Scopelianos , William Douglas Shaw, Jr. , James H. Silver , John Spaltro , Christine Trepanier , David J. Wilson
CPC分类号： A61F2/91 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , A61L2420/02 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/20 , C08L27/16 , C08L27/14 , C08L27/12
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
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公开(公告)号：US6153252A
公开(公告)日：2000-11-28
申请号：US294164
申请日：1999-04-19
IPC分类号： A61F2/00 , A61F2/82 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L33/10 , A61L33/14 , A61L33/16 , A61L27/00 , B05D7/22
CPC分类号： A61F2/82 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0047 , A61F2250/0067 , A61L2300/606 , A61L2420/02
摘要： A process is provided for coating stents having a first and second surface with passages there between to avoid blockage and bridging of the passages. The process comprises contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while maintaining a fluid flow through said passages sufficient prevent the film forming biocompatible polymer from substantially blocking said passages. Also described are stents coated by this process.
摘要翻译： 提供了一种用于涂覆具有第一和第二表面的支架的过程，其间具有通道，以避免通道的阻塞和桥接。 该方法包括使支架与含有成膜生物相容性聚合物的液体涂布溶液接触，所述液体涂覆溶液在适于允许成膜生物相容性聚合物涂覆支架的至少一个表面的条件下同时保持流经所述通道的流体足以防止膜形成生物相容性 聚合物基本上阻挡所述通道。 还描述了通过该方法涂覆的支架。
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公开(公告)号：US08303609B2
公开(公告)日：2012-11-06
申请号：US09966447
申请日：2001-09-28
IPC分类号： A61B17/08
CPC分类号： A61L31/16 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61B2017/0641 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2220/0016 , A61F2250/0067 , A61F2310/0097 , A61F2310/00976 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2300/608 , C08L27/12 , C08L27/16 , C08L27/14
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。
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公开(公告)号：US06746773B2
公开(公告)日：2004-06-08
申请号：US09962292
申请日：2001-09-25
IPC分类号： B23B2700
CPC分类号： A61F2/91 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B17/54 , A61B2017/06028 , A61F2/064 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/18 , Y10T428/3154 , A61K2300/00 , C08L27/16 , C08L27/12 , C08L27/14
摘要： The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which coatings/films are present on the device in an amount effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of the device in the mammal, and contain a film-forming polyfluoro copolymer containing the polymerized residue of a moiety selected from the group consisting of vinylidenefluoride and tetrafluoroethylene copolymerized with a second moiety other than the first moiety, wherein the relative amounts of the polymerized residue of the first and second moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.
摘要翻译： 本发明包括用于可植入医疗装置的生物相容性涂层和膜，以及包含施加到其表面上的这种涂层和膜的医疗装置，该涂层/薄膜以有效提供惰性表面接触的量存在于该装置上 与植入该哺乳动物的哺乳动物的身体组织，并且含有成膜多氟共聚物，其含有选自由与第一部分以外的第二部分共聚的偏氟乙烯和四氟乙烯的部分的聚合残基， 其中所述第一和第二部分的聚合残基的相对量有效地提供具有有效用于涂覆可植入med装置的性质的涂层和膜。
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公开(公告)号：US06776796B2
公开(公告)日：2004-08-17
申请号：US09850232
申请日：2001-05-07
IPC分类号： A61F206
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/727 , A61K45/06 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61K2300/00
摘要： A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
摘要翻译： 药物和药物递送系统可用于治疗血管疾病。 局部递送系统用雷帕霉素或其他合适的药物，药剂或化合物包被并且经内镜递送用于治疗和预防经皮冠状动脉冠状动脉造影术后的新生内膜增生。 药物或药剂的局部递送提供了更高的效力和更低的全身毒性。
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8.发明申请Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease 审中-公开用于预防和治疗血管疾病的药物/药物输送系统公开(公告)号：US20120226347A1
公开(公告)日：2012-09-06
申请号：US13472587
申请日：2012-05-16
IPC分类号： A61L27/54
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/727 , A61K45/06 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61K2300/00
摘要： A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
摘要翻译： 药物和药物递送系统可用于治疗血管疾病。 局部递送系统用雷帕霉素或其他合适的药物，药剂或化合物包被并且经内镜递送用于治疗和预防经皮冠状动脉冠状动脉造影术后的新生内膜增生。 药物或药剂的局部递送提供了更高的效力和更低的全身毒性。
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9.发明申请Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease 审中-公开用于预防和治疗血管疾病的药物/药物输送系统公开(公告)号：US20100268329A1
公开(公告)日：2010-10-21
申请号：US12827458
申请日：2010-06-30
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/727 , A61K45/06 , A61L2300/252 , A61L2300/41 , A61L2300/416 , A61K2300/00
摘要： A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
摘要翻译： 药物和药物递送系统可用于治疗血管疾病。 局部递送系统用雷帕霉素或其他合适的药物，药剂或化合物包被并且经内镜递送用于治疗和预防经皮冠状动脉冠状动脉造影术后的新生内膜增生。 药物或药剂的局部递送提供了更高的效力和更低的全身毒性。
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10.发明授权公开(公告)号：US08790391B2
公开(公告)日：2014-07-29
申请号：US13420959
申请日：2012-03-15
申请人： Carol Wright , Gerard H. Llanos , Ronald Rakos , Kristen King , Robert Falotico
发明人： Carol Wright , Gerard H. Llanos , Ronald Rakos , Kristen King , Robert Falotico
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： The present disclosure pertains to stents having a coating applied thereto, wherein the coating comprises a biocompatible polymer/drug mixture, as well as devices comprising a metallic stent, a biocompatible polymeric carrier and a drug.
摘要翻译： 本公开涉及具有施加于其上的涂层的支架，其中所述涂层包括生物相容性聚合物/药物混合物，以及包含金属支架，生物相容性聚合物载体和药物的装置。
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