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公开(公告)号：US20070225579A1
公开(公告)日：2007-09-27
申请号：US11568995
申请日：2005-05-09
IPC分类号： A61B5/1455
CPC分类号： G01J3/44
摘要： The present invention provides a spectroscopic system and in particular a fiber optic probe for in vivo detection of vulnerable atherosclerotic plaque inside the cardiovascular system of a patient. Detection of vulnerable plaque is based on a location dependent measurement of concentration levels of cardiac marker molecules flowing in the blood stream. Concentration level determination is preferably based on surface-enhanced Raman spectroscopic techniques providing sufficient sensitivity for determination of these concentration levels. Acquisition of spectroscopic data during moving of the fiber optic probe through the cardiovascular system with controlled velocity allows to precisely locate vulnerable plaque in the cardiovascular system.
摘要翻译： 本发明提供一种光谱系统，特别是一种用于体内检测患者心血管系统内易受损的动脉粥样硬化斑块的光纤探针。 脆弱斑块的检测是基于在血流中流动的心脏标志物分子的浓度水平的位置依赖性测量。 浓度水平测定优选基于表面增强拉曼光谱技术，为确定这些浓度水平提供足够的灵敏度。 在光纤探针通过受控速度的心血管系统移动期间获取光谱数据可以精确定位心血管系统中易受伤害的斑块。
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2.发明申请PHANTOM FOR ULTRASOUND GUIDED NEEDLE INSERTION AND METHOD FOR MAKING THE PHANTOM 审中-公开超声波引导针插入物及其制造方法公开(公告)号：US20100196867A1
公开(公告)日：2010-08-05
申请号：US12668075
申请日：2008-07-08
IPC分类号： G09B23/30
CPC分类号： G09B23/28
摘要： The invention relates to a phantom for simulating the ultrasound guided insertion of a needle in a blood vessel of a human body site. The phantom comprises: a skin mimicking layer (2), formed in a first material; —a tissue mimicking layer (3), formed in a second material and at least one artificial blood vessel (4a, 4b, 4c), formed in a third material, the first, second and third material being arranged to reproduce both the mechanical and the ultrasound properties of the corresponding parts of the human body site. Thanks to the invention, the phantom permits a realistic simulation of a human body site behavior.
摘要翻译： 本发明涉及用于模拟人体部位的血管中的针的超声引导插入的模型。 该体模包括：形成在第一材料中的皮肤模拟层（2） - 形成在第二材料中的组织模拟层（3）和形成在第三材料中的至少一个人造血管（4a，4b，4c），所述第一，第二和第三材料被布置成再现机械和 人体部位相应部位的超声特性。 由于本发明，幻影允许人体现场行为的真实模拟。
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公开(公告)号：US20090275823A1
公开(公告)日：2009-11-05
申请号：US11721061
申请日：2005-12-09
申请人： Shervin Ayati , Francisco Morales.Serrano , Hans Feil , Sieglinde Neerken , Gerhardus Wilhelmus Lucassen
发明人： Shervin Ayati , Francisco Morales.Serrano , Hans Feil , Sieglinde Neerken , Gerhardus Wilhelmus Lucassen
CPC分类号： A61B5/489 , A61B5/150022 , A61B5/150175 , A61B5/150389 , A61B5/150503 , A61B5/150748 , A61B5/15109 , A61B5/15113 , A61B5/15121 , A61B5/1519 , A61M5/427
摘要： The present invention provides a highly automated puncture system for inserting a cannula or a needle into a blood vessel of a person or an animal. The puncture system has an acquisition module that allows for determining at least one location of a blood vessel underneath the surface of a skin and that is further enabled to determine an optimal puncture location that is well suitable for inserting a cannula into the blood vessel. Further, the puncture system has an actuator for moving and aligning the cannula to a determined position. The system is further adapted to autonomously insert the cannula into the blood vessel for multiple purposes, such as blood withdrawal, venous medication and infusions.
摘要翻译： 本发明提供了一种用于将插管或针插入人或动物的血管中的高度自动化的穿刺系统。 穿刺系统具有采集模块，其允许确定皮肤表面下方的血管的至少一个位置，并且还能够确定非常适合于将插管插入血管中的最佳穿刺位置。 此外，穿刺系统具有用于将插管移动并对准到确定位置的致动器。 该系统进一步适于将插管自动地插入血管用于多种目的，例如抽血，静脉药物和输注。
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公开(公告)号：US08821482B2
公开(公告)日：2014-09-02
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译： 本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。 激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。 这反过来又减少皱纹（30）。 该装置可以包括皱纹确定装置（52,54,56,58）。 聚焦光学元件（50）可以具有至少0.4的数值孔径。 本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。 优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。
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公开(公告)号：US20090273778A1
公开(公告)日：2009-11-05
申请号：US12296694
申请日：2007-04-06
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00
摘要： A method of performing surface-enhanced resonant Raman spectroscopy (SERRS) in respect of a sample (100) provided on an aggregated colloid nano-particle having a plasmon absorption band similar to that of a target molecule. The sample is irradiated at a first wavelength (λ1).coinciding with the absorption band of the plasma, to obtain (12) a SERRS spectra for deriving (10) a fingerprint of the target melecule, and at a second wavelength (λ2), coinciding with the absorption band caused by aggregate of said nano- particles, to obtain (14) a SERS spectra for monitoring (16) said aggregation.
摘要翻译： 对于具有与靶分子相似的等离子体激元吸收带的凝集胶体纳米粒子上的样品（100），进行表面增强共振拉曼光谱（SERRS）的方法。 以等离子体的吸收带与第一波长（λ1）照射样品，以获得（12）用于导出（10）目标分子的指纹并且在第二波长（λ2）的（12）的SERRS光谱， 与由所述纳米颗粒的聚集体引起的吸收带一致，以获得（14）用于监测（16）所述聚集的SERS光谱。
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公开(公告)号：US20090171205A1
公开(公告)日：2009-07-02
申请号：US12159636
申请日：2006-12-28
申请人： Aleksey Kharin , Sieglinde Neerken
发明人： Aleksey Kharin , Sieglinde Neerken
CPC分类号： A61B5/0059 , A61B5/489 , A61B8/00
摘要： A method and system for detecting blood vessels and precisely determining parameters in respect thereof, such as geometry, depth and diameter. Optical imaging, such as IR imaging, is used to obtain a general overview (16) of the blood vessel pattern in a region of interest from which a target vessel can be defined and its lateral position determined. Ultrasound imaging is then employed to precisely measure parameters, such as depth and diameter, in respect of the target vessel. The resultant system is of relatively low cost, and relatively simple to implement and use.
摘要翻译： 用于检测血管并精确地确定其参数的方法和系统，例如几何形状，深度和直径。 使用诸如IR成像的光学成像来获得目标血管可被定义的感兴趣区域中的血管图案的一般概述（16），并确定其横向位置。 然后使用超声成像来精确测量关于目标血管的参数，例如深度和直径。 所得到的系统成本相对较低，并且相对简单的实施和使用。
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公开(公告)号：US20130171615A1
公开(公告)日：2013-07-04
申请号：US13514734
申请日：2010-12-07
申请人： Bart Edward Jozef Gusta Van Meerbergen , Oana Mihaela Piciu , Ron Gill , Kristiane Anne Schmidt , Sieglinde Neerken , Marc Wilhelmus Gijsbert Ponjee , Zeynep Seflek , Roel Penterman , Paul Arnold Van De Wiel
发明人： Bart Edward Jozef Gusta Van Meerbergen , Oana Mihaela Piciu , Ron Gill , Kristiane Anne Schmidt , Sieglinde Neerken , Marc Wilhelmus Gijsbert Ponjee , Zeynep Seflek , Roel Penterman , Paul Arnold Van De Wiel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N1/06 , C12Q1/689 , C12Q1/6895 , C12Q2527/125 , C12Q2527/119
摘要： Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
摘要翻译： 提供了用于选择性裂解包含微生物如细菌的样品中的细胞的方法和装置。 通过在碱性条件下将样品温育在非离子型洗涤剂中来获得选择性裂解。
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公开(公告)号：US20090118670A1
公开(公告)日：2009-05-07
申请号：US11911670
申请日：2006-04-21
申请人： Sieglinde Neerken , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Gerhardus Wilhelmus Lucassen , Eric Cohen-Solal , Claude Cohen-Bacrie , Balasundara Raju , Marion Geerligs , Nicole Leonarda Wilhelmina Eikelenberg , Carole Schwach
发明人： Sieglinde Neerken , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Gerhardus Wilhelmus Lucassen , Eric Cohen-Solal , Claude Cohen-Bacrie , Balasundara Raju , Marion Geerligs , Nicole Leonarda Wilhelmina Eikelenberg , Carole Schwach
CPC分类号： A61M5/427 , A61B5/0059 , A61B5/0066 , A61B5/0095 , A61B5/15003 , A61B5/150175 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150748 , A61B5/1535 , A61B5/155 , A61B5/489 , A61B8/06 , A61B8/0833
摘要： The invention relates to a highly automated puncture system for inserting a cannula or a needle into a blood vessel of a person or an animal. The puncture system has an acquisition module that allows for determining at least a location of a blood vessel underneath of the surface of a skin and is further enabled to determine an optimal puncture location that is potentially suitable for inserting a cannula into the blood vessel. Further, the puncture system has tissue analysis means to analyse the skin surface in the proximity of the puncture location to check whether the skin is suitable for punctuation. This prevents puncturing the skin at locations where scars, wound and the like can be found.
摘要翻译： 本发明涉及一种用于将插管或针插入人或动物的血管中的高度自动化的穿刺系统。 穿刺系统具有采集模块，其允许确定皮肤表面下方的血管的至少位置，并且还能够确定潜在地适合于将插管插入血管中的最佳穿刺位置。 此外，穿刺系统具有组织分析装置，用于分析穿刺位置附近的皮肤表面，以检查皮肤是否适于标点符号。 这可以防止在可以发现疤痕，伤口等的位置刺穿皮肤。
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9.发明申请System for Guiding a Probe Over the Surface of the Skin of a Patient or an Animal 审中-公开用于指导患者或动物皮肤表面的探针的系统公开(公告)号：US20080221519A1
公开(公告)日：2008-09-11
申请号：US11916823
申请日：2006-06-06
申请人： Carol Schwach , Sieglinde Neerken , Gerhardus Wilhelmus Lucassen , Marion Geerligs , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Nicole Leonarda Wilhelmina Eikelenberg
发明人： Carol Schwach , Sieglinde Neerken , Gerhardus Wilhelmus Lucassen , Marion Geerligs , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Nicole Leonarda Wilhelmina Eikelenberg
IPC分类号： A61M5/42
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0095 , A61B5/1075 , A61B8/06 , A61B8/0833 , A61B8/0841 , A61B8/4209 , A61B8/4227 , A61B8/4461 , A61M5/427
摘要： The invention relates to a system for guiding a probe over the surface of the skin of a patient. Performing measurements with ultrasound techniques for small structures such as blood vessels need well-defined spatial relationship between the measuring probe and the tissue which has to be examined. The invention seeks to ensure a movement of the measuring probe in a controlled and precise way over the skin. Therefore, a system 1 is suggested which comprises a probe holder 2 to which a probe 4 is rigidly attachable. The probe holder 2 is moveable along at least one rail 5, 5′. The rail can be wrapped around the patient 3 or a body part 7 of the patient or the animal.
摘要翻译： 本发明涉及一种用于将探针引导到患者皮肤表面上的系统。 用诸如血管等小结构的超声技术进行测量需要测量探针和必须检查的组织之间的明确的空间关系。 本发明寻求确保测量探针以可控且精确的方式在皮肤上移动。 因此，提出了一种系统1，其包括探针支架2，探针4刚刚可附接到探针支架2。 探针支架2可沿着至少一个导轨5,5'移动。 轨道可以包裹在病人3或患者或动物的身体部分7周围。
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公开(公告)号：US09863006B2
公开(公告)日：2018-01-09
申请号：US14118570
申请日：2012-04-30
摘要： The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
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