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    Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
    1.
    发明授权
    Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants 有权
    分离淀粉样蛋白抑制化合物的方法和使用分离自Un藜和相关植物的化合物

    公开(公告)号：US07314642B2

    公开(公告)日：2008-01-01

    申请号：US10624435

    申请日：2003-07-21

    申请人： Gerardo Castillo ,  Paula Y. Choi ,  Beth Nguyen ,  Alan D. Snow

    发明人： Gerardo Castillo ,  Paula Y. Choi ,  Beth Nguyen ,  Alan D. Snow

    IPC分类号： A61K36/00 ,  A61K31/35

    CPC分类号： A61K36/74 ,  A61K31/215 ,  A61K31/353 ,  A61K2300/00

    摘要： Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.

    摘要翻译： 测定指导的亲和力分离和反相高压液相色谱（HPLC）方法来分离，测试和表征Cat's Claw或Uncaria tomentos中最活跃的水溶性成分。 这些组分似乎占淀粉样蛋白或Abeta原纤维发生抑制活性的大部分。 在相关体外和/或动物模型中测试通过HPLC分离的各个级分和/或化合物，并且发现其一致地证明对淀粉样蛋白或Aβ原纤维生成的抑制。 公开了相关提取方法。

    Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
    3.
    发明授权
    Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants 有权
    分离淀粉样蛋白抑制化合物的方法和使用分离自Un藜和相关植物的化合物

    公开(公告)号：US07285293B2

    公开(公告)日：2007-10-23

    申请号：US10624436

    申请日：2003-07-21

    申请人： Gerardo Castillo ,  Paula Y. Choi ,  Beth P. Nguyen ,  Alan D. Snow

    发明人： Gerardo Castillo ,  Paula Y. Choi ,  Beth P. Nguyen ,  Alan D. Snow

    IPC分类号： A61K36/00 ,  A61K31/35

    CPC分类号： A61K36/74 ,  A61K31/215 ,  A61K31/353 ,  A61K2300/00

    摘要： Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.

    摘要翻译： 测定指导的亲和力分离和反相高压液相色谱（HPLC）方法来分离，测试和表征Cat's Claw或Uncaria tomentos中最活跃的水溶性成分。 这些组分似乎占淀粉样蛋白或Abeta原纤维发生抑制活性的大部分。 在相关体外和/或动物模型中测试通过HPLC分离的各个级分和/或化合物，并且发现其一致地证明对淀粉样蛋白或Aβ原纤维生成的抑制。 公开了相关提取方法。