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1.发明申请Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110046185A1
公开(公告)日：2011-02-24
申请号：US12852188
申请日：2010-08-06
申请人： Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER
发明人： Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER
IPC分类号： A61K31/4439 , C07D233/72 , A61K31/4166 , A61P3/10 , A61P3/04 , A61P25/32 , A61P25/34 , A61P25/18 , A61P25/28 , C07D401/04 , C07D409/04 , C07D417/10 , A61K31/428
CPC分类号： C07D233/72 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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2.发明申请Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use 有权芳基氨基芳基 - 烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20090215728A1
公开(公告)日：2009-08-27
申请号：US12365940
申请日：2009-02-05
IPC分类号： A61K31/675 , C07D233/76 , A61K31/4174 , A61K31/4439 , C07D401/12 , C07F9/6506 , A61P3/10
CPC分类号： C07D233/72
摘要： This invention relates to arylaminoaryl-alkyl-substituted imidazolidone-2,4-diones of formula (I) and also to their physiologically tolerated salts: Wherein R, R′, R1 to R10, A, D, E, G, L and p are as defined herein. The invention also relates to processes for preparing them, pharmaceutical compositions comprising them and their therapeutic use. The compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
摘要翻译： 本发明涉及式（I）的芳基氨基芳基 - 烷基取代的咪唑烷酮-2,4-二酮，也涉及其生理上耐受的盐：其中R，R'，R 1至R 10，A，D，E，G，L和p 如本文所定义。 本发明还涉及制备它们的方法，包含它们的药物组合物及其治疗用途。 该化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。
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3.发明申请Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110053947A1
公开(公告)日：2011-03-03
申请号：US12852216
申请日：2010-08-06
IPC分类号： A61K31/4985 , C07D241/04 , C07D233/40 , C07D401/04 , A61K31/497 , A61K31/4166 , A61K31/4439 , A61P25/18 , A61P25/28
CPC分类号： C07D233/74
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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4.发明申请Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof 审中-公开新的苯基取代的咪唑啉，其制备方法，包含所述化合物的药物及其用途公开(公告)号：US20110178134A1
公开(公告)日：2011-07-21
申请号：US12852038
申请日：2010-08-06
申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
IPC分类号： A61K31/4439 , C07D233/02 , C07D401/06 , A61K31/4166 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/18
CPC分类号： C07D233/72 , C07D401/06
摘要： The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
摘要翻译： 本发明涉及其中基团具有所述含义的式（I）化合物及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。
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5.发明申请PYRROLIDINONE DERIVATIVES AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS 有权吡咯烷酮衍生物作为GPR119调节剂用于治疗糖尿病，肥胖，DYSLIPIDEMIA和相关疾病公开(公告)号：US20140099333A1
公开(公告)日：2014-04-10
申请号：US14048425
申请日：2013-10-08
申请人： Lothar SCHWINK , Martin BOSSART , Heiner GLOMBIK , Matthias GOSSEL , Dieter KADEREIT , Thomas KLABUNDE , Thomas MAIER , Siegfried STENGELIN
发明人： Lothar SCHWINK , Martin BOSSART , Heiner GLOMBIK , Matthias GOSSEL , Dieter KADEREIT , Thomas KLABUNDE , Thomas MAIER , Siegfried STENGELIN
IPC分类号： A61K31/497 , A61K31/4015 , C07D401/12 , A61K31/4439 , A61K31/4545 , C07D405/14 , C07D401/14 , A61K31/444 , C07D413/14 , A61K45/06 , C07D207/12 , C07D417/14
CPC分类号： A61K31/497 , A61K31/4015 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K45/06 , A61K48/00 , C07D207/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to pyrrolidinone derivatives. The pyrrolidinone derivatives are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of pyrrolidinone derivatives as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及吡咯烷酮衍生物。 吡咯烷酮衍生物是GPR119调节剂，可用于预防和/或治疗糖尿病，肥胖，血脂异常和相关疾病。 本发明还涉及吡咯烷酮衍生物作为药物中的活性成分的用途，以及包含它们的药物组合物。
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6.发明申请NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权新乙酰胆碱取代的芳基二氢喹啉酮，其制备方法及其作为药物使用公开(公告)号：US20090264403A1
公开(公告)日：2009-10-22
申请号：US12191662
申请日：2008-08-14
申请人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
发明人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
IPC分类号： A61K31/4725 , C07D401/10 , C07D405/14 , A61K31/55
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/10 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryidihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氮杂环酰基取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氮杂环酰基取代的芳基二氢异喹啉酮或其衍生物的药物，以及使用偶氮基酰基取代的芳酰基异喹啉酮 的本发明及其衍生物作为MCH拮抗剂。
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7.发明申请NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权新型氨基醇取代的芳基二氢喹啉酮，其制备方法及其作为药物使用公开(公告)号：US20090082391A1
公开(公告)日：2009-03-26
申请号：US12191697
申请日：2008-08-14
申请人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
发明人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
IPC分类号： A61K31/4365 , C07D495/04
CPC分类号： C07D471/04 , C07D217/24 , C07D401/12 , C07D451/06 , C07D453/02 , C07D455/06
摘要： The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及氨基醇取代的芳基二氢异喹啉酮的用途 的本发明及其衍生物作为MCH拮抗剂。
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8.发明申请ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT 有权芳基取代的多环酰胺，其生产方法及其作为药物的用途公开(公告)号：US20100298378A1
公开(公告)日：2010-11-25
申请号：US12846075
申请日：2010-07-29
IPC分类号： A61K31/4545 , C07D487/08 , A61K31/407 , C07D401/14 , A61K31/454 , C07D498/10 , A61K31/424 , A61K31/4439 , C07D417/14 , A61K31/427 , A61P3/06 , A61P3/10
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.
摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，以及其生理上耐受的盐和生理功能衍生物; 在说明书中解释符号和自由基以及含有它们的药物组合物以及使用它们的治疗方法。
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9.发明申请NOVEL AZACYCLYL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权新乙酰胆碱取代的芳香族二亚胺，其制备方法及其作为药物使用公开(公告)号：US20090082339A1
公开(公告)日：2009-03-26
申请号：US12191630
申请日：2008-08-14
申请人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
发明人： Lothar SCHWINK , Siegfried STENGELIN , Matthias GOSSEL , Gerhard HESSLER , Torsten HAACK , Petra LENNIG
IPC分类号： A61K31/551 , C07D495/04 , C07D243/08 , A61K31/517 , C07D239/91 , A61K31/519
CPC分类号： C07D491/04 , C07D239/91 , C07D403/10 , C07D495/04 , C12N9/99
摘要： The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氮杂环酰基取代的芳基噻吩并嘧啶酮或其衍生物的药物，以及使用偶氮酰基取代的芳基噻吩并嘧啶酮 的本发明及其衍生物作为MCH拮抗剂。
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10.发明申请公开(公告)号：US20100249097A1
公开(公告)日：2010-09-30
申请号：US12705140
申请日：2010-02-12
IPC分类号： A61K31/397 , C07D405/12 , A61K31/4025 , A61P3/10 , A61P3/00 , A61K31/4709 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/55
CPC分类号： C07D405/12 , A61K31/397 , A61K31/4025 , A61K31/4525 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D307/12
摘要： The invention relates to substituted tetrahydronaphthalenes and derivatives thereof, and also to the physiologically compatible salts and physiologically functional derivatives thereof, to preparation thereof, to medicaments comprising at least one inventive substituted tetrahydronaphthalene or derivative thereof, and to the use of the inventive substituted tetrahydronaphthalenes and derivatives thereof as medicaments.
摘要翻译： 本发明涉及取代的四氢萘及其衍生物，以及其生理上相容的盐和生理功能衍生物及其制备方法，涉及包含至少一种本发明取代的四氢化萘或其衍生物的药物，以及本发明取代的四氢萘和 其衍生物作为药物。
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