专利检索 ap:("Gerhard JAEHNE" OR "Siegfried STENGELIN" OR "Matthias GOSSEL" OR "Thomas KLABUNDE" OR "Irvin WINKLER") AND inv:"Thomas KLABUNDE" 第 1 页

1.

发明申请
Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开
标题翻译：芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途

公开(公告)号：US20110053947A1

公开(公告)日：2011-03-03

申请号：US12852216

申请日：2010-08-06

申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

IPC分类号： A61K31/4985 , C07D241/04 , C07D233/40 , C07D401/04 , A61K31/497 , A61K31/4166 , A61K31/4439 , A61P25/18 , A61P25/28

CPC分类号： C07D233/74

摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。所述化合物例如适合作为抗肥胖药物。

2.

发明申请
Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开
标题翻译：芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途

公开(公告)号：US20110046185A1

公开(公告)日：2011-02-24

申请号：US12852188

申请日：2010-08-06

申请人： Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

发明人： Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

IPC分类号： A61K31/4439 , C07D233/72 , A61K31/4166 , A61P3/10 , A61P3/04 , A61P25/32 , A61P25/34 , A61P25/18 , A61P25/28 , C07D401/04 , C07D409/04 , C07D417/10 , A61K31/428

CPC分类号： C07D233/72 , C07D401/04 , C07D405/04 , C07D409/04

摘要： The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。所述化合物例如适合作为抗肥胖药物。

3.

发明申请
Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use 有权
标题翻译：芳基氨基芳基 - 烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途

公开(公告)号：US20090215728A1

公开(公告)日：2009-08-27

申请号：US12365940

申请日：2009-02-05

申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER

IPC分类号： A61K31/675 , C07D233/76 , A61K31/4174 , A61K31/4439 , C07D401/12 , C07F9/6506 , A61P3/10

CPC分类号： C07D233/72

摘要： This invention relates to arylaminoaryl-alkyl-substituted imidazolidone-2,4-diones of formula (I) and also to their physiologically tolerated salts: Wherein R, R′, R1 to R10, A, D, E, G, L and p are as defined herein. The invention also relates to processes for preparing them, pharmaceutical compositions comprising them and their therapeutic use. The compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.

摘要翻译： 本发明涉及式（I）的芳基氨基芳基 - 烷基取代的咪唑烷酮-2,4-二酮，也涉及其生理上耐受的盐：其中R，R'，R 1至R 10，A，D，E，G，L和p 如本文所定义。本发明还涉及制备它们的方法，包含它们的药物组合物及其治疗用途。该化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。

4.

发明申请
Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof 审中-公开
标题翻译：新的苯基取代的咪唑啉，其制备方法，包含所述化合物的药物及其用途

公开(公告)号：US20110178134A1

公开(公告)日：2011-07-21

申请号：US12852038

申请日：2010-08-06

申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI

发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI

IPC分类号： A61K31/4439 , C07D233/02 , C07D401/06 , A61K31/4166 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/18

CPC分类号： C07D233/72 , C07D401/06

摘要： The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.

摘要翻译： 本发明涉及其中基团具有所述含义的式（I）化合物及其生理上相容的盐。所述化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。

5.

发明申请
PYRROLIDINONE DERIVATIVES AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS 有权
标题翻译：吡咯烷酮衍生物作为GPR119调节剂用于治疗糖尿病，肥胖，DYSLIPIDEMIA和相关疾病

公开(公告)号：US20140099333A1

公开(公告)日：2014-04-10

申请号：US14048425

申请日：2013-10-08

申请人： Lothar SCHWINK , Martin BOSSART , Heiner GLOMBIK , Matthias GOSSEL , Dieter KADEREIT , Thomas KLABUNDE , Thomas MAIER , Siegfried STENGELIN

发明人： Lothar SCHWINK , Martin BOSSART , Heiner GLOMBIK , Matthias GOSSEL , Dieter KADEREIT , Thomas KLABUNDE , Thomas MAIER , Siegfried STENGELIN

IPC分类号： A61K31/497 , A61K31/4015 , C07D401/12 , A61K31/4439 , A61K31/4545 , C07D405/14 , C07D401/14 , A61K31/444 , C07D413/14 , A61K45/06 , C07D207/12 , C07D417/14

CPC分类号： A61K31/497 , A61K31/4015 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K45/06 , A61K48/00 , C07D207/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14

摘要： The present invention relates to pyrrolidinone derivatives. The pyrrolidinone derivatives are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of pyrrolidinone derivatives as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

摘要翻译： 本发明涉及吡咯烷酮衍生物。吡咯烷酮衍生物是GPR119调节剂，可用于预防和/或治疗糖尿病，肥胖，血脂异常和相关疾病。本发明还涉及吡咯烷酮衍生物作为药物中的活性成分的用途，以及包含它们的药物组合物。

6.

发明申请
(CARBOXYLALKYLENEPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME AS A MEDICAMENT 审中-公开
标题翻译：（羧甲基烯丙基）苯并噻唑类，其生产方法及其作为药物的用途

公开(公告)号：US20130231388A1

公开(公告)日：2013-09-05

申请号：US13864622

申请日：2013-04-17

申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK

发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK

IPC分类号： C07C237/04

CPC分类号： C07C237/04 , C07C235/80

摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.

摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。

7.

发明申请
HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS 有权
标题翻译：具有OXO基团的杂环取代的甲氧基衍生物，其制备方法和作为药物的用途

公开(公告)号：US20120004165A1

公开(公告)日：2012-01-05

申请号：US13154946

申请日：2011-06-07

申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE

发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE

IPC分类号： A61K38/28 , C07D265/36 , C07D215/227 , C07D277/68 , C07D498/04 , A61K31/404 , A61K31/538 , A61K31/5383 , A61K31/4704 , A61K31/428 , A61K38/27 , A61K31/702 , A61K31/4439 , A61K38/22 , A61K31/445 , A61K31/4985 , A61K31/451 , A61P3/10 , C07D209/34

CPC分类号： C07D209/34 , C07D215/227 , C07D265/36 , C07D277/68 , C07D498/04

摘要： Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicamentsThe invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.

摘要翻译： 具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途本发明涉及具有氧代基的杂环取代的甲氧基苯基衍生物及其生理上相容的盐。本发明涉及其中R 1，R 2，R 3，R 4，R 10，X，n，B 1，B 2，B 3和B 4各自如上所定义的式Ⅰ化合物及其生理上相容的盐。该化合物适用于例如治疗糖尿病。

8.

发明申请
SPIROCYCLICALLY SUBSTITUTED 1,3-PROPANE DIOXIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 有权
标题翻译：螺旋取代的1,3-丙二酮衍生物，其制备方法及其作为药物的用途

公开(公告)号：US20120004187A1

公开(公告)日：2012-01-05

申请号：US13176333

申请日：2011-07-05

申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE

发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE

IPC分类号： A61K38/16 , A61K31/337 , A61P3/10 , C07D213/64 , C07D305/04 , C07C59/68 , A61K31/44 , A61K31/19

CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06

摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.

摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。该化合物适用于例如治疗糖尿病。