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1.发明授权Multiple sclerosis-associated retroviral (MSRV) nucleic acids corresponding to the Env region 失效对应于Env区域的多发性硬化相关逆转录病毒（MSRV）核酸公开(公告)号：US07771927B1
公开(公告)日：2010-08-10
申请号：US09319156
申请日：1998-07-07
申请人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
发明人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
CPC分类号： C07K14/4713 , C07K14/005 , C12N2740/10022
摘要： The invention concerns a nucleic material, in isolated or purified state, and a nucleotide fragment comprising a nucleotide sequence selected from the group consisting in (i) the sequences SEQ ID NO: 112, SEQ ID NO:114, SEQ ID NO: 117, SEQ ID NO: 120, SEQ ID NO. 124, SEQ ID NO: 130, SEQ ID NO: 141 and SEQ ID NO: 142, (ii) the complementary sequences of sequences (i); and (iii) the sequences equivalent to sequences (ii) and (iii), in particular the sequence having for every series of 100 contiguous monomers, at least 50%, preferably 70% homology with sequences (i) and (ii) respectively. The invention also concerns their uses for detecting a retrovirus associated with multiple sclerosis and/or rheumatoid arthritis.
摘要翻译： 本发明涉及分离或纯化状态的核酸，以及包含选自（i）序列SEQ ID NO：112，SEQ ID NO：114，SEQ ID NO：117， SEQ ID NO：120，SEQ ID NO： 124，SEQ ID NO：130，SEQ ID NO：141和SEQ ID NO：142，（ii）序列（i）的互补序列; 和（iii）与序列（ii）和（iii）相当的序列，特别是具有每100个连续单体的序列的序列，分别与序列（i）和（ii）具有至少50％，优选70％的同源性。 本发明还涉及其用于检测与多发性硬化和/或类风湿性关节炎相关的逆转录病毒的用途。
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2.发明授权Isolated multiple sclerosis (MS)-associated retrovirus (MSRV) nucleic acids corresponding to the gag region 有权分离的多发性硬化（MS）相关逆转录病毒（MSRV）核酸对应于gag区域公开(公告)号：US08088910B2
公开(公告)日：2012-01-03
申请号：US12776893
申请日：2010-05-10
申请人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
发明人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
CPC分类号： C07K14/4713 , C07K14/005 , C12N2740/10022
摘要： An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences set forth in (a) or (b).
摘要翻译： 一种分离的多核苷酸，其具有选自（a）SEQ ID NO：21，（b）编码具有选自SEQ ID NO：25和26的肽序列的多肽的全长序列的核苷酸序列 ，和（c）与（a）或（b）中列出的序列的全长互补序列。
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3.发明申请RETROVIRAL NUCLEIC MATERIAL AND NUCLEOTIDE FRAGMENTS, IN PARTICULAR ASSOCIATED WITH MULTIPLE SCLEROSIS AND/OR RHEUMATOID ARTHRITIS, FOR DIAGNOSTIC, PROPHYLACTIC AND THERAPEUTIC USES 有权特别是与多发性硬化症和/或RHEUMATOID ARTHRITIS相关的替代性核材料和核素片段，用于诊断，预防和治疗用途公开(公告)号：US20100285448A1
公开(公告)日：2010-11-11
申请号：US12776893
申请日：2010-05-10
申请人： Glaucia PARANHOS-BACCALA , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
发明人： Glaucia PARANHOS-BACCALA , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
CPC分类号： C07K14/4713 , C07K14/005 , C12N2740/10022
摘要： An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences set forth in (a) or (b).
摘要翻译： 一种分离的多核苷酸，其具有选自（a）SEQ ID NO：21，（b）编码具有选自SEQ ID NO：25和26的肽序列的多肽的全长序列的核苷酸序列 ，和（c）与（a）或（b）中列出的序列的全长互补序列。
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4.发明授权Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的公开(公告)号：US07674888B2
公开(公告)日：2010-03-09
申请号：US11581030
申请日：2006-10-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N9/1241 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.
摘要翻译： 本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。
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公开(公告)号：US6001987A
公开(公告)日：1999-12-14
申请号：US691563
申请日：1996-08-02
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： G01N33/566 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P37/00 , C07K14/15 , C07K16/10 , C12N7/00 , C12N15/00 , C12N15/09 , C12N15/48 , C12Q1/04 , C12Q1/68 , C12R1/92 , C07H21/04 , A61K39/12 , A61K39/21
CPC分类号： C07K14/005 , C12Q1/6883 , C12Q1/702 , A61K2039/51 , A61K38/00 , A61K39/00 , C12N2740/10022
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译： 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。
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6.发明授权Isolated nucleotide sequences associated with multiple sclerosis or rheumatoid arthritis and a process of detecting 失效与多发性硬化或类风湿性关节炎相关的分离的核苷酸序列和检测过程公开(公告)号：US06582703B2
公开(公告)日：2003-06-24
申请号：US08979847
申请日：1997-11-26
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N9/1241 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in methods of diagnosis, prophylaxis, and therapy.
摘要翻译： 本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。
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7.发明授权Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的公开(公告)号：US07932350B2
公开(公告)日：2011-04-26
申请号：US11463109
申请日：2006-08-08
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： C07K14/005 , C07K14/15 , C07K14/00 , C07H23/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N2740/10022 , C12Q1/6883 , C12Q1/702
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译： 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。
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8.发明申请Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的公开(公告)号：US20070031452A1
公开(公告)日：2007-02-08
申请号：US11581030
申请日：2006-10-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Garson , Philip Tuke
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Garson , Philip Tuke
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N9/1241 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.
摘要翻译： 本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。
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9.发明授权Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的公开(公告)号：US06579526B1
公开(公告)日：2003-06-17
申请号：US09374766
申请日：1999-08-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N2740/10022 , C12Q1/6883 , C12Q1/702
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译： 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。
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10.发明授权LTR region of MSRV-1 and the proteins it encodes, and probes and methods for detecting MSRV-1 retrovirus 失效LTR区域的MSRV-1及其编码的蛋白质，以及用于检测MSRV-1逆转录病毒的探针和方法公开(公告)号：US07381817B2
公开(公告)日：2008-06-03
申请号：US10637565
申请日：2003-08-11
CPC分类号： C07K14/005 , C12N2740/10022
摘要： The invention relates to: a nucleotide fragment of an MSRV-1 LTR-RU5 region, comprising a nucleotide sequence encoding the expression of a protein, wherein the protein comprises a peptide sequence selected from the group consisting of: SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4; complementary nucleotide fragments; probes and primers that hybridize to the fragment; proteins encoded by the fragment; antibodies directed against the proteins encoded by the fragment; and processes for detecting the presence of MSRV-1 using a probe or an antibody of the invention.
摘要翻译： 本发明涉及：MSRV-1LTR-RU5区域的核苷酸片段，其包含编码蛋白质表达的核苷酸序列，其中所述蛋白质包含选自下组的肽序列：SEQ ID NO：2，SEQ ID NO： SEQ ID NO：3和SEQ ID NO：4; 互补核苷酸片段; 与片段杂交的探针和引物; 由片段编码的蛋白质; 针对由片段编码的蛋白质的抗体; 以及使用本发明的探针或抗体检测MSRV-1的存在的方法。
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