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    Mutated env gene, mutated env glycoprotein and the use thereof
    5.
    发明申请
    Mutated env gene, mutated env glycoprotein and the use thereof 审中-公开
    突变的env基因，突变的env糖蛋白及其用途

    公开(公告)号：US20050065320A1

    公开(公告)日：2005-03-24

    申请号：US10487094

    申请日：2002-09-06

    申请人： Frederic Bedin ,  Frederic Beynard ,  Bernard Verbier ,  Yasemin Ataman-Onal

    发明人： Frederic Bedin ,  Frederic Beynard ,  Bernard Verbier ,  Yasemin Ataman-Onal

    IPC分类号： C12N15/09 ,  A61K39/00 ,  A61P31/18 ,  C07K14/16 ,  C12N15/48 ,  C07H21/04 ,  C12N7/00 ,  C12N15/867 ,  C12Q1/70

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C12N2740/16122

    摘要： The invention relates to a mutated env gene which codes for a mutated envelope glycoprotein of virus HIV-1. In relation to the env gene of a reference or primary infection primary isolate, said gene presents at least two mutations at the glycosylation sites which are preserved from one primary isolate to another. Each mutation consists in the replacement of an AAC or AAT codon which codes for an asparagine with a CAG or CAA codon which codes for a glutamine, the two mutations at least being selected from the following: (a) at least two mutations in the part of the env gene that codes for region C3 of the env protein; (b) at least one mutation in the part that codes for region C3 and at least one mutation in the part that codes for region V3; (c) at least one mutation in the part that codes for region C2 and at least one mutation in the part that codes for region V3 chosen from the glycosylation sites at codons 862-864 and 970-972; (d) at least one mutation in the part that codes for region C2 selected from the glycosylation sites at codons 667-669, 679-681, 700-702,763-765, 844-846 and at least one mutation in the part that codes for region V3. Alternatively, the mutated env gene consists of any one of the following sequences: SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10, or the complementary sequences thereof. The invention also relates to the mutated Env glycoprotein and the use of the gene and the glycoprotein in a pharmaceutical composition in order to produce antibodies and to evaluate a therapeutic agent.

    摘要翻译： 本发明涉及编码病毒HIV-1的突变包膜糖蛋白的突变型env基因。 关于参考或原代感染初级分离株的env基因，所述基因在糖基化位点处至少存在两个突变，其从一个主要分离物保留到另一个。 每个突变都在于替换AAC或AAT密码子，其编码具有编码谷氨酰胺的CAG或CAA密码子的天冬酰胺，所述两个突变至少从以下选择：（a）部分中的至少两个突变 的env基因编码env蛋白的区域C3; （b）编码区域C3的部分中的至少一个突变和编码区域V3的部分中的至少一个突变; （c）在编码区域C2的部分中至少有一个突变，以及编码从密码子862-864和970-972处的糖基化位点选择的区域V3的部分中的至少一个突变; （d）编码选自密码子667-669,679-681,700-702,763-765,844-846的糖基化位点的区域C2部分中的至少一个突变，以及编码 区域V3。 或者，突变的env基因由以下序列之一组成：SEQ ID NO：8，SEQ ID NO：9或SEQ ID NO：10，或其互补序列。 本发明还涉及突变的Env糖蛋白以及药物组合物中基因和糖蛋白在产生抗体中的用途以及评价治疗剂。

    Viral isolates associated with multiple sclerosis
    7.
    发明授权
    Viral isolates associated with multiple sclerosis 有权
    与多发性硬化相关的病毒分离物

    公开(公告)号：US06184025B2

    公开(公告)日：2001-02-06

    申请号：US09200990

    申请日：1998-11-30

    申请人： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    发明人： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    IPC分类号： C12N112

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  Y10S435/912

    摘要： Composition comprising two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of said virus, and a second agent, or a variant of said second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.

    摘要翻译： 包含与多发性硬化相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族相关的人病毒或所述病毒的变体组成的第一药剂和第二药剂， 或所述第二药剂的变体，这两种源自相同病毒株的两种致病和/或感染剂分别选自1992年7月22日以ECACC保藏的保藏号为V92072202的POL-2和存储的MS7PG的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。