公开(公告)号：US11505567B2

公开(公告)日：2022-11-22

申请号：US16630372

申请日：2018-07-12

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/00

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US11419884B2

公开(公告)日：2022-08-23

申请号：US16312506

申请日：2017-06-23

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Markus Jondelius Hederos ,  Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  C12P1/04 ,  A61P31/04 ,  A61K31/7016 ,  C07H1/00 ,  C12P19/04 ,  C12N9/10 ,  A61K31/716 ,  A61K31/7032

Abstract: The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.

公开(公告)号：US11939351B2

公开(公告)日：2024-03-26

申请号：US18057355

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US10696705B2

公开(公告)日：2020-06-30

申请号：US16063367

申请日：2016-12-16

Applicant: Glycom A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US11767340B2

公开(公告)日：2023-09-26

申请号：US17653819

申请日：2022-03-07

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00 ,  C07H1/06

CPC classification number: C07H1/06 ,  A23L33/125 ,  A23L33/40 ,  A61K31/702 ,  C07H13/04 ,  A23V2002/00 ,  C07B2200/03

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US11267839B2

公开(公告)日：2022-03-08

申请号：US16913656

申请日：2020-06-26

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US11142541B2

公开(公告)日：2021-10-12

申请号：US16626122

申请日：2018-06-27

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  B01D61/02 ,  B01D61/04 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C12P19/04 ,  C08B37/00 ,  C12P19/12 ,  A23L33/00 ,  C12P19/18

Abstract: The invention relates to separation of disaccharides from tri- or higher oligosaccharides by nanofiltration.

公开(公告)号：US10800802B2

公开(公告)日：2020-10-13

申请号：US15703551

申请日：2017-09-13

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: A23L33/195 ,  B01D15/36 ,  B01D61/02 ,  B01D61/14 ,  B01D61/16 ,  B01D61/58 ,  C07H1/06 ,  C07H1/08 ,  C07H13/02 ,  C07H13/04 ,  C07H23/00 ,  C08B37/00 ,  C12P19/04 ,  C12P19/18

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US12054513B2

公开(公告)日：2024-08-06

申请号：US18057360

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US11214588B2

公开(公告)日：2022-01-04

申请号：US16626245

申请日：2018-06-27

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Markus Jondelius Hederos

IPC: A23L33/00 ,  C12P19/18 ,  C08B37/00 ,  B01D61/02 ,  B01D61/58 ,  B01D69/12 ,  C07H3/06 ,  C12P19/04 ,  B01D61/14 ,  C07H1/06 ,  B01D61/04 ,  B01D69/02 ,  B01D71/56 ,  B01D71/58 ,  C12P19/12

Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.