公开(公告)号：US11505567B2

公开(公告)日：2022-11-22

申请号：US16630372

申请日：2018-07-12

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/00

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US12054513B2

公开(公告)日：2024-08-06

申请号：US18057360

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US10899782B2

公开(公告)日：2021-01-26

申请号：US16082848

申请日：2017-03-07

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Nikolay Khanzhin ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/08 ,  C07H1/06 ,  B01D61/14 ,  C08B37/00 ,  B01D61/16 ,  C07H13/04 ,  A23L33/195 ,  B01D15/36 ,  C07H23/00 ,  C12P19/04 ,  C12P19/18 ,  B01D61/02 ,  B01D61/58 ,  C07H13/02

Abstract: The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nano-filtration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

公开(公告)号：US10676770B2

公开(公告)日：2020-06-09

申请号：US15536537

申请日：2015-12-16

Applicant: Glycom A/S

Inventor： Gyula Dekany ,  Györgyi Osztrovszky ,  Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C12P19/18 ,  C07H1/06 ,  C07H3/06

Abstract: The invention relates to a method for selective crystallization of 2′-FL from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution.

公开(公告)号：US11939351B2

公开(公告)日：2024-03-26

申请号：US18057355

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US10696705B2

公开(公告)日：2020-06-30

申请号：US16063367

申请日：2016-12-16

Applicant: Glycom A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US20150320780A1

公开(公告)日：2015-11-12

申请号：US14651710

申请日：2013-12-13

Applicant: GLYCOM A/S

Inventor： Elise Champion ,  Gyula Dekany ,  Nikolay Khanzhin ,  Pierre Chassagne ,  Györgyi Osztrovszky

IPC: A61K31/7016 ,  A23L1/09 ,  A23L1/29 ,  C12P19/14 ,  C12P19/12

CPC classification number: A61K31/7016 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/702 ,  C07H1/00 ,  C07H3/06 ,  C12P19/00 ,  C12P19/12 ,  C12P19/14

Abstract: A method to form a mixture containing at least one of 2′-FL (2′-O-fucosyllactose, Fuc(α1-2)Gal(β1-4)Glc) and 3-FL (3-O-fucosyllactose, Gal(β1-4)[Fuc(α1-3)]Glc) characterized in that DFL (difucosyl-lactose, Fuc(α1-2)Gal(β1-4)[Fuc(α1-3)]Glc) is subjected to partial hydrolysis, e.g. enzymatic hydrolysis or acid hydrolysis.

Abstract translation: 形成含有2'-FL（2'-O-岩藻糖基乳糖，Fuc（α1-2）Gal（＆bgr; 1-4）Glc）和3-FL（3-O-岩藻糖基乳糖）中至少一种的混合物的方法， Gal（＆bgr; 1-4）[Fuc（α1-3）] Glc），其特征在于DFL（二氟蔗糖 - 乳糖，Fuc（α1-2）Gal（＆bgr; 1-4）[Fuc（α1-3）] Glc ）进行部分水解，例如 酶水解或酸水解。

公开(公告)号：US11767340B2

公开(公告)日：2023-09-26

申请号：US17653819

申请日：2022-03-07

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00 ,  C07H1/06

CPC classification number: C07H1/06 ,  A23L33/125 ,  A23L33/40 ,  A61K31/702 ,  C07H13/04 ,  A23V2002/00 ,  C07B2200/03

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US11267839B2

公开(公告)日：2022-03-08

申请号：US16913656

申请日：2020-06-26

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US10407516B2

公开(公告)日：2019-09-10

申请号：US15799386

申请日：2017-10-31

Applicant: Glycom A/S

Inventor： Pierre Chassagne ,  Nikolay Khanzhin ,  Agnese Maggi

IPC: C08B37/00 ,  A23L33/125 ,  A23L33/00

Abstract: Crystalline pLNnH, useful in a pharmaceutical or nutritional composition, is disclosed.