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公开(公告)号：US20130116283A1
公开(公告)日：2013-05-09
申请号：US13710604
申请日：2012-12-11
申请人： GRÜNENTHAL GMBH
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： Substituted indole derivatives, processes for the preparation thereof, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted indole derivatives to treat pain and other conditions and for other medical purposes.
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公开(公告)号：US09580386B2
公开(公告)日：2017-02-28
申请号：US14459540
申请日：2014-08-14
申请人： GRÜNENTHAL GMBH
发明人： Bert Nolte , Wolfgang Schröder , Klaus Linz , Werner Englberger , Hans Schick , Heinz Graubaum , Birgit Braun , Sigrid Ozegowski , József Bálint , Helmut Sonnenschein
IPC分类号： C07C211/00 , C07D209/20 , C07C211/40 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C275/24 , C07C311/07 , C07C311/18 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08 , A61K31/135 , A61K45/06 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , C07C211/54 , C07C237/24 , C07C311/37 , C07D251/48
CPC分类号： C07D209/20 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , A61K45/06 , C07C211/40 , C07C211/54 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C237/24 , C07C275/24 , C07C311/07 , C07C311/18 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/48 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译： 本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。
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公开(公告)号：US09403767B2
公开(公告)日：2016-08-02
申请号：US13803295
申请日：2013-03-14
申请人： Grünenthal GmbH
发明人： Bert Nolte , Wolfgang Schröder , Klaus Linz , Werner Englberger , Hans Schick , Heinz Graubaum , Birgit Braun , Sigrid Ozegowski , József Bálint , Helmut Sonnenschein
IPC分类号： C07C211/00 , C07D209/20 , C07C211/40 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C275/24 , C07C311/07 , C07C311/18 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08 , A61K31/135 , A61K45/06 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , C07C211/54 , C07C237/24 , C07C311/37 , C07D251/48
CPC分类号： C07D209/20 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , A61K45/06 , C07C211/40 , C07C211/54 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C237/24 , C07C275/24 , C07C311/07 , C07C311/18 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/48 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译： 本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。
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