Membrane anchor/active compound conjugate, its preparation and its uses
    1.
    发明授权
    Membrane anchor/active compound conjugate, its preparation and its uses 失效
    膜锚/活性化合物缀合物及其制备及其用途

    公开(公告)号:US6024964A

    公开(公告)日:2000-02-15

    申请号:US466695

    申请日:1995-06-06

    CPC分类号: C07K16/2863 C07K2317/34

    摘要: According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.

    摘要翻译: 根据某些实施方案,本发明涉及使用通过将至少一种膜 - 锚定化合物与病毒,细菌或质膜蛋白的至少一部分序列缀合而产生的免疫缀合物来产生抗体的方法。 免疫缀合物的优点在于即使没有冷却也可以储存很长时间。 根据某些实施方案,本发明涉及用于特异性诱导细胞毒性T淋巴细胞的免疫偶联物,其包含来自至少一种膜锚定化合物和蛋白质的缀合物,其含有病毒的至少一种杀伤T细胞表位, 细菌,寄生虫或肿瘤抗原,或至少包含病毒,细菌或寄生虫蛋白或肿瘤抗原的至少一种杀伤T细胞表位的部分序列。

    Method for binding basophils and mast cells
    3.
    发明授权
    Method for binding basophils and mast cells 有权
    嗜碱性粒细胞和肥大细胞的结合方法

    公开(公告)号:US06949346B2

    公开(公告)日:2005-09-27

    申请号:US09996030

    申请日:2001-11-16

    摘要: The present invention relates to an antibody for the detection quantification, or isolation of basophils, mast cells, the precursor cells of basophils or mast cells, or a surface structure of basophils or mast cells. This antibody corresponds to an antibody with the designation 97A6, produced and released by hybridoma cells that were deposited in accordance with the Budapest Treaty on Feb. 12, 1997 under accession number DSM ACC 2297 at Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ).

    摘要翻译: 本发明涉及用于检测定量或分离嗜碱性粒细胞,肥大细胞,嗜碱性粒细胞或肥大细胞的前体细胞或嗜碱性粒细胞或肥大细胞的表面结构的抗体。 该抗体对应于名称为97A6的抗体,其由1997年2月12日按照布达佩斯条约保藏的杂交瘤细胞产生和释放,保藏号为DSM ACC 2297,位于德意志山脉冯Mikroorganismen und Zellkulturen有限公司(DSMZ)。

    Monoclonal antibody W8B2 and method of use
    5.
    发明授权
    Monoclonal antibody W8B2 and method of use 有权
    单克隆抗体W8B2及其使用方法

    公开(公告)号:US07364863B2

    公开(公告)日:2008-04-29

    申请号:US11077486

    申请日:2005-03-09

    摘要: The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.

    摘要翻译: 本发明涉及用于分离和/或鉴定间充质干细胞的单克隆抗体或其片段。 在这方面,抗体或其片段与抗原结合,该抗原与通过由DSMZ [德国专利公开说明书]中保藏的杂交瘤细胞系W8B2产生的抗体相结合 微生物和细胞培养物],号码为DSM ACC2567。

    Antibody BV10A4H2 specific for human FLT3/FLK2 receptor and mybridoma
    6.
    发明授权
    Antibody BV10A4H2 specific for human FLT3/FLK2 receptor and mybridoma 失效
    抗体BV10A4H2特异于人FLT3 / FLK2受体和骨髓母细胞瘤

    公开(公告)号:US5777084A

    公开(公告)日:1998-07-07

    申请号:US792626

    申请日:1997-01-31

    申请人: Hans-Jorg Buhring

    发明人: Hans-Jorg Buhring

    摘要: The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. One example of such a monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2248 at the German Collection of Microorganisms and Cell Cultures (DSMZ).

    摘要翻译: 本发明涉及与人FLT3 / FLK2受体蛋白特异性结合的单克隆抗体。 本发明还涉及产生这种抗体的杂交瘤细胞,以及用于产生这种杂交瘤细胞的方法。 这样的单克隆抗体的一个实例是由德国收集的微生物和细胞培养物(DSMZ)在DSM 2248号保藏的杂交瘤细胞产生和释放的抗体。

    Antibody 4G8B4B12
    7.
    发明授权
    Antibody 4G8B4B12 失效
    抗体4G8B4B12

    公开(公告)号:US6156882A

    公开(公告)日:2000-12-05

    申请号:US105596

    申请日:1998-06-26

    摘要: The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. The monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2249 at the German Collection of Microorganisms and Cell Cultures (DSMZ) and designated as 4G8B4B12.

    摘要翻译: 本发明涉及与人FLT3 / FLK2受体蛋白特异性结合的单克隆抗体。 本发明还涉及产生这种抗体的杂交瘤细胞,以及用于产生这种杂交瘤细胞的方法。 单克隆抗体是由DSM 2249在德国微生物和细胞培养物收集库(DSMZ)上保藏并被指定为4G8B4B12的杂交瘤细胞产生和释放的抗体。