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    Monoclonal antibody W8B2 and method of use
    4.
    发明授权
    Monoclonal antibody W8B2 and method of use 有权
    单克隆抗体W8B2及其使用方法

    公开(公告)号：US07364863B2

    公开(公告)日：2008-04-29

    申请号：US11077486

    申请日：2005-03-09

    申请人： Hans-Jorg Buhring ,  Reiner Lammers ,  Wichard Vogel

    发明人： Hans-Jorg Buhring ,  Reiner Lammers ,  Wichard Vogel

    IPC分类号： G01N33/53 ,  C12N5/00 ,  C07K16/00 ,  C12P21/08

    CPC分类号： G01N33/6887 ,  C07K16/28 ,  G01N33/56966

    摘要： The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.

    摘要翻译： 本发明涉及用于分离和/或鉴定间充质干细胞的单克隆抗体或其片段。 在这方面，抗体或其片段与抗原结合，该抗原与通过由DSMZ [德国专利公开说明书]中保藏的杂交瘤细胞系W8B2产生的抗体相结合 微生物和细胞培养物]，号码为DSM ACC2567。

    Antibodies for identifying and/or isolating at least one cell population
    7.
    发明授权
    Antibodies for identifying and/or isolating at least one cell population 有权
    用于鉴定和/或分离至少一个细胞群体的抗体

    公开(公告)号：US07741114B2

    公开(公告)日：2010-06-22

    申请号：US12401539

    申请日：2009-03-10

    申请人： Hans-Joerg Buehring ,  Reiner Lammers ,  Selim Kuci ,  Tim Conze

    发明人： Hans-Joerg Buehring ,  Reiner Lammers ,  Selim Kuci ,  Tim Conze

    IPC分类号： C12N5/12 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0797

    CPC分类号： C07K16/18 ,  C07K16/28

    摘要： Monoclonal antibodies, or fragments thereof, are used for isolating and/or identifying at least one cell population. The cell population can include any of the following types of cells: haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on 14 Aug. 2002, and DSM ACC2551, on 12 Jul. 2002.

    摘要翻译： 单克隆抗体或其片段用于分离和/或鉴定至少一个细胞群体。 细胞群可以包括以下类型的细胞：造血干细胞，神经元干细胞，神经元祖细胞，间充质干细胞和间充质祖细胞。 抗体或其片段与由通过杂交瘤细胞系CUB1，CUB2，CUB3和CUB4产生的抗体结合的抗原结合，所述抗体以DSM ACC2569，DSM 2002年8月14日的ACC2566和DSM ACC2565以及2002年7月12日的DSM ACC2551。