公开(公告)号：US11913888B2

公开(公告)日：2024-02-27

申请号：US17264588

申请日：2019-04-09

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Xiangguang Mao ,  Masanori Kobayashi ,  Hirotoshi Terada ,  Ikuo Arata ,  Masataka Ikesu

IPC: G01N21/88 ,  G01N21/95 ,  G02B21/02 ,  G02B21/33 ,  G02B21/36

CPC classification number: G01N21/8806 ,  G01N21/9505 ,  G02B21/02 ,  G02B21/33 ,  G02B21/361

Abstract: A solid immersion lens unit includes a solid immersion lens having a contact surface for coming into contact with semiconductor device formed of a silicon substrate and a spherical surface to be disposed to face an objective lens; a holder holding the solid immersion lens; and an optical element held by the holder to be positioned between the objective lens and the solid immersion lens. The solid immersion lens transmits light having at least a part of wavelength in a range of 200 nm or greater and 1100 nm or lower. The optical element corrects aberration caused by a difference in refractive indices between the silicon substrate and the solid immersion lens.

公开(公告)号：US09134296B2

公开(公告)日：2015-09-15

申请号：US14356487

申请日：2012-10-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Norikazu Sugiyama ,  Takuji Kataoka ,  Ikuo Arata

IPC: G01N21/01 ,  G01N33/50 ,  G02B21/08 ,  G01N21/49 ,  G01N21/59 ,  G02B21/36

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。

公开(公告)号：US12235433B2

公开(公告)日：2025-02-25

申请号：US17634036

申请日：2020-07-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tomonori Nakamura ,  Ikuo Arata ,  Xiangguang Mao

IPC: G02B21/33 ,  G02B7/02

Abstract: A solid immersion lens unit includes a solid immersion lens and a holder for swingably holding the solid immersion lens. The solid immersion lens includes a first lens portion formed of a first material, and a second lens portion formed of a second material having a refractive index smaller than a refractive index of the first material and coupled to the first lens portion. The first lens portion includes a contact surface for contacting with an observation object and a convex first spherical surface. The second lens portion includes a concave second spherical surface facing the first spherical surface and a convex third spherical surface to be disposed to face an objective lens. The holder has a contact portion configured to be contactable with the third spherical surface.

公开(公告)号：US11988497B2

公开(公告)日：2024-05-21

申请号：US17634298

申请日：2020-08-31

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Ikuo Arata ,  Satoshi Takimoto ,  Kenichi Ohtsuka

IPC: G01B11/06 ,  G01B5/06 ,  G01B11/02 ,  G02B17/08

CPC classification number: G01B11/0625 ,  G01B5/06 ,  G01B11/02 ,  G01B11/06 ,  G02B17/0816 ,  G02B17/0868

Abstract: An optical unit includes an input portion configured to have measurement light having a wavelength extending from an ultraviolet region to a visible region input thereto, an optical system configured to condense the measurement light in a state where a chromatic aberration is caused to occur, and an opening portion configured not to image light having a wavelength in the visible region and to image light having a wavelength in the ultraviolet region of the measurement light having a chromatic aberration having occurred therein.

公开(公告)号：US20200241275A1

公开(公告)日：2020-07-30

申请号：US16851960

申请日：2020-04-17

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tomonori Nakamura ,  Ikuo Arata ,  Yoshihiro Ito

IPC: G02B21/36 ,  G02B21/00 ,  G02B5/00 ,  G02B27/00 ,  G02B21/04 ,  G02B21/16 ,  G02B21/24

Abstract: An optical device for microscopic observation 4 comprises: a cold stop 13 having openings 13d, 13e corresponding to a low-magnification microscope optical system 5 and being a stop member arranged in a vacuum vessel 12 to let the light from the sample S pass to the camera 3; a warm stop 10 having an opening 14 corresponding to a high-magnification microscope optical system 5 and being a stop member arranged outside the vacuum vessel 12 to let the light from the sample S pass toward the cold stop 13; and a support member 11 supporting the warm stop 10 so that the warm stop can be inserted to or removed from on the optical axis of the light from the sample S, wherein the warm stop 10 has a reflective surface 15 on the camera 3 side and wherein the opening 14 is smaller than the openings 13d, 13e.

公开(公告)号：US10545309B2

公开(公告)日：2020-01-28

申请号：US15507252

申请日：2015-09-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hirotoshi Terada ,  Ikuo Arata ,  Masataka Ikesu

IPC: G02B7/02 ,  G02B7/16 ,  G02B21/00 ,  G02B21/02 ,  G02B21/26 ,  G02B21/33 ,  G02B21/36

Abstract: A solid immersion lens holder includes a first member having a first opening disposing a spherical face portion therein so that a part of the spherical face portion protrudes toward an objective lens side and a second member having a second opening disposing a contact portion therein so that a contact face protrudes toward a side opposite to the objective lens side. The first member includes three plate members disposed on the objective lens side with respect to the first opening. Each of the three plate members is provided with a protrusion portion capable of contacting the spherical face portion.

公开(公告)号：US20140287452A1

公开(公告)日：2014-09-25

申请号：US14356487

申请日：2012-10-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Norikazu Sugiyama ,  Takuji Kataoka ,  Ikuo Arata

IPC: G01N33/50

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。

公开(公告)号：US12163900B2

公开(公告)日：2024-12-10

申请号：US17795570

申请日：2020-11-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masataka Ikesu ,  Ikuo Arata ,  Yoshihiro Ito ,  Toshimichi Ishizuka

IPC: G01N21/95 ,  G01N21/71 ,  G01N21/88

Abstract: The semiconductor failure analysis device includes: a light source configured to generate irradiation light with which the semiconductor device is irradiated; a solid immersion lens disposed on an optical path of the irradiation light; a light detection unit configured to receive reflected light and to output a detection signal according to the reflected light; an optical system 6 disposed between the light source and the solid immersion lens to emit the irradiation light to the semiconductor device via the solid immersion lens and disposed between the solid immersion lens and the light detection unit to emit the reflected light received via the solid immersion lens to the light detection unit. The light source emits the irradiation light having a center wavelength of 880 nm or more and 980 nm or less. The solid immersion lens is formed of GaAs.

公开(公告)号：US10663709B2

公开(公告)日：2020-05-26

申请号：US16025288

申请日：2018-07-02

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tomonori Nakamura ,  Ikuo Arata ,  Yoshihiro Ito

IPC: G02B21/36 ,  G02B21/00 ,  G02B5/00 ,  G02B27/00 ,  G02B21/04 ,  G02B21/16 ,  G02B21/24

Abstract: An optical device for microscopic observation 4 comprises: a cold stop 13 having openings 13d, 13e corresponding to a low-magnification microscope optical system 5 and being a stop member arranged in a vacuum vessel 12 to let the light from the sample S pass to the camera 3; a warm stop 10 having an opening 14 corresponding to a high-magnification microscope optical system 5 and being a stop member arranged outside the vacuum vessel 12 to let the light from the sample S pass toward the cold stop 13; and a support member 11 supporting the warm stop 10 so that the warm stop can be inserted to or removed from on the optical axis of the light from the sample S, wherein the warm stop 10 has a reflective surface 15 on the camera 3 side and wherein the opening 14 is smaller than the openings 13d, 13e.

公开(公告)号：US10558010B2

公开(公告)日：2020-02-11

申请号：US15504395

申请日：2015-09-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hirotoshi Terada ,  Ikuo Arata ,  Masataka Ikesu

IPC: G02B7/02 ,  G02B7/16 ,  G02B21/00 ,  G02B21/02 ,  G02B21/26 ,  G02B21/33 ,  G02B21/36

Abstract: A solid immersion lens holder includes a first member having a first opening disposing a spherical face portion therein so that a part of the spherical face portion protrudes toward an objective lens side and a second member having a second opening disposing a contact portion therein so that a contact face protrudes toward a side opposite to the objective lens side. The first member includes three protrusion portions extending from an inner face of the first opening toward a center of the first opening and configured to be contactable with the spherical face portion.