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公开(公告)号：US10935497B2
公开(公告)日：2021-03-02
申请号：US15736797
申请日：2016-07-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Shunichiro Nobuki , Muneo Maeshima , Kenta Imai
IPC: G01N21/76 , G01N21/00 , G01N21/64 , G02B6/26 , G01N21/25 , G02B6/42 , G01N21/03 , F21V8/00 , G01N35/10
Abstract: A highly reflective light-guide system has a highly reflective light-guide surface for reflecting light that has been emitted from a sample and has entered from an entry port opposing a window material and propagating the same to an exit port opposing a light reception surface of a photodetector. An optical filter is provided in a space surrounded by the window material, the photodetector, and the highly reflective light-guide system and transmits the signal luminescence to be measured that is emitted from the sample between the window material and photodetector. The optical filter is fixed to the window material or photodetector by an adhesive, and the peripheral shape of the optical filter is smaller than the shape of the inside of a fitting part to which the optical filter is fitted and that is formed on the highly reflective light-guide system.
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2.发明申请BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE 有权生物分子检测方法，生物分子检测装置和分析装置公开(公告)号：US20150308977A1
公开(公告)日：2015-10-29
申请号：US14418480
申请日：2013-06-28
Applicant: Hitachi High-Technologies Corporation
Inventor： Toshiro Saito , Kenta Imai , Kyoko Imai , Kazumichi Imai , Itaru Yanagi , Yoshimitsu Yanagawa , Masahiko Ando , Naoshi Itabashi
IPC: G01N27/414 , G01N33/543
CPC classification number: G01N27/4145 , G01N27/4148 , G01N33/48721 , G01N33/543 , G01N33/54306 , G01N37/00
Abstract: The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.
Abstract translation: 本发明旨在提供一种用于在宽动态范围内检测具有高灵敏度和高产量的生物分子的方法和装置，而不需要预先对样品进行浓度调节。 本发明将电荷载体特异性地结合到检测目标生物分子，并且通过测量随着生物分子和电荷载体的共轭体通过微孔而发生的电流变化逐个检测检测目标生物分子。 生物分子样品的高通量检测是可能的与一组检测器。
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公开(公告)号：US09759681B2
公开(公告)日：2017-09-12
申请号：US14418480
申请日：2013-06-28
Applicant: Hitachi High-Technologies Corporation
Inventor： Toshiro Saito , Kenta Imai , Kyoko Imai , Kazumichi Imai , Itaru Yanagi , Yoshimitsu Yanagawa , Masahiko Ando , Naoshi Itabashi
IPC: G01N27/414 , G01N33/487 , G01N33/543 , G01N37/00
CPC classification number: G01N27/4145 , G01N27/4148 , G01N33/48721 , G01N33/543 , G01N33/54306 , G01N37/00
Abstract: The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.
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公开(公告)号：US11215627B2
公开(公告)日：2022-01-04
申请号：US15756431
申请日：2016-07-01
Inventor： Kenta Imai , Toshiharu Suzuki , Shigeki Matsubara , Takayuki Sugime , Shunsuke Sasaki , Elke Faatz , Beatus Ofenloch-Haehnle
Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.
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公开(公告)号：US11549957B2
公开(公告)日：2023-01-10
申请号：US15750526
申请日：2016-07-25
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke Sasaki , Kenta Imai , Toshiharu Suzuki , Katsuhiko Sakamoto
IPC: G01N35/00 , B01L9/00 , G01N27/327 , G01N33/53 , G01N35/10 , G01N35/04 , G01J1/32 , G01N21/76 , B01L3/00
Abstract: An automated analyzer includes an analysis operation part that causes a sample and a reagent to react and based on the reaction result performs analysis of the sample, wherein: the automated analyzer includes a plurality of units constituting the analysis operation part, a temperature adjustment mechanism that heats or cools the units, a temperature sensor that measures the temperature of the units, and a control part that controls the temperature adjustment mechanism. The control part sets the measurement startable temperature range of each unit, which is the temperature range of the operation specification thereof, and the operable temperature range, which is a temperature range that is wider than the measurement startable temperature range, and starts the analysis process of the sample when the temperature of each unit has entered the operable temperature range.
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Patent Agency Ranking
公开(公告)号：US11519924B2
公开(公告)日：2022-12-06
申请号：US16329021
申请日：2017-08-04
Applicant: Hitachi High-Technologies Corporation
Inventor： Daisuke Ebihara , Kenta Imai , Yoshihiro Yamashita , Shigeki Matsubara , Taku Sakazume
IPC: G01N35/00
Abstract: In order to aspire to higher sensitivity in an automatic analysis device, it is important to prevent the mixing of dust and the like in a reaction part in which a sample and a reagent react. The present invention presents an automatic analysis device that is provided with a configuration for making the pressure inside a specific block in the device such as a reaction part, or inside the device become positive. By making the pressure become positive and forming an air flow that flows out from the inside of the reaction part or the device, it is possible to limit, to a certain amount or less, the amount of dust penetrating into the reaction part.
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公开(公告)号：US11340241B2
公开(公告)日：2022-05-24
申请号：US16477219
申请日：2018-01-24
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke Sasaki , Takenori Okusa , Yoshihiro Yamashita , Hiroki Fujita , Kenta Imai , Toshiharu Suzuki
Abstract: An automated analyzer capable of continuously performing supply of consumables is realized while continuing measurement is performed, by a simple and small amount of mechanism. An automated analyzer includes a unit that executes processing necessary for sample analysis; a consumable supply unit that supplies consumables necessary for the sample analysis to the unit; and a control device that controls operations of the unit and the consumable supply unit, in which the consumable supply unit includes a consumable container holding portion that holds a consumable storage container in which consumables is aligned and accommodated, a preliminary storage portion that temporarily holds the consumables taken out from the consumable storage container, and a transport mechanism that transports the consumables to the unit, and in which the control device transports and stores at least a portion of the consumables taken out from the consumable storage container in the preliminary storage portion.
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公开(公告)号：US11320443B2
公开(公告)日：2022-05-03
申请号：US16477221
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroya Umeki , Kenta Imai , Yoshihiro Yamashita , Shunsuke Sasaki , Akihiro Endou
Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
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公开(公告)号：US11161118B2
公开(公告)日：2021-11-02
申请号：US16477535
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroki Fujita , Toshiharu Suzuki , Takenori Okusa , Shunsuke Sasaki , Yoshihiro Yamashita , Kenta Imai
Abstract: The mixing of reagents with each other in the reagent storage flow paths of an automatic analyzer is suppressed before and after exchange of the reagents, which are capable of being replenished without stopping analysis. An exchangeable reagent container that accommodates a reagent is connected to a reagent storage flow path that stores a portion of the reagent. The reagent storage flow path has first and second flow paths in which the second flow path is branched from the first flow path. A reagent syringe applies a negative or a positive pressure to the first and second flow paths; and a valve controls the flow path through which the reagent is sent. As a result, the reagent supplied to a measurement portion at a predetermined timing is switched from the reagent container to the reagent storage flow path wherein the reagent can be supplied without stopping analysis.
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公开(公告)号：US10768189B2
公开(公告)日：2020-09-08
申请号：US15111195
申请日：2015-01-09
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Kenta Imai , Yoshinori Negishi , Toshinari Sakurai , Kyoko Imai
IPC: G01N35/00 , G01N27/416 , G01N27/49 , G01N35/10
Abstract: When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.
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