-
公开(公告)号：US10761000B2
公开(公告)日：2020-09-01
申请号：US15320769
申请日：2015-06-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke Sasaki , Yoshihiro Yamashita
Abstract: In a liquid stirring method, after a second liquid is discharged into a reaction container accommodating a first liquid from a dispensing probe provided with a dispensing tip at the leading end thereof, a mixture of the first liquid and second liquid in the container is stirred by being sucked out and discharged by the dispensing probe. The number of stirrings through sucking out and discharging is changed according to the total volume of the first liquid and second liquid. If the total volume of the first liquid and second liquid is below a preset threshold, sucking out and discharging is repeated for a prescribed number of times.
-
公开(公告)号：US20150293135A1
公开(公告)日：2015-10-15
申请号：US14648355
申请日：2013-12-03
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Yoshihiro Yamashita , Takaaki Hagiwara , Toshiharu Suzuki
IPC: G01N35/00
CPC classification number: G01N35/00722 , G01N35/0098 , G01N35/1004 , G01N2035/00891
Abstract: It is determined whether an automatic analysis device is in a state where it is necessary to perform periodic cleaning or periodic replacement on a B/F separation passage of a reaction liquid suction nozzle 120 for B/F separation or the like and a detection passage of a reaction liquid suction nozzle 123 for detection, a detection unit 124, and the like, based on the properties of a specimen, a reagent, and a reaction liquid which is obtained by reacting the specimen and the reagent, an analysis protocol which defines treatment conditions of these solutions, and the number of times of dispensing, feeding, and measuring the solutions; and the determined result is displayed on a display 130 as a signal. Accordingly, the automatic analysis device is provided so as to be able to perform adequate maintenance in accordance with analysis conditions.
Abstract translation: 确定自动分析装置是否处于需要在用于B / F分离等的反应液吸嘴120的B / F分离通道上进行周期性清洁或周期性更换的状态，以及B / F分离装置的检测通道 用于检测的反应液吸引嘴123，检测单元124等，基于通过使样本和试剂反应获得的试样，试剂和反应液的性质，定义处理的分析方案 这些解决方案的条件以及分配，进料和测量溶液的次数; 并且将确定的结果作为信号显示在显示器130上。 因此，自动分析装置被设置成能够根据分析条件进行适当的维护。
-
公开(公告)号：US20150056098A1
公开(公告)日：2015-02-26
申请号：US14356962
申请日：2012-12-14
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Toru Inaba , Shinya Matsuoka , Taku Sakazume , Yoshihiro Yamashita , Masafumi Shimada
IPC: G01N27/74 , G01N33/553
CPC classification number: G01N27/745 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/553 , G01N2446/00
Abstract: A problem of a sample analysis device that uses magnetic particles is the difficulty in uniformly capturing magnetic particles, specifically the poor uniformity in the vicinity of channel side walls. This causes poor analysis accuracy and reproducibility. The present invention is intended to provide a means to uniformly capture magnetic particles in the vicinity of channel side walls. Specifically, the present invention provides an analysis device that includes a detection channel with an inlet and an outlet through which a sample liquid containing a specific substance and magnetic particles is flowed in and out of the channel, and magnetic field generating means capable of varying the magnitude of the magnetic field in a predetermined region of the detection channel. The width of the magnet in the detector is greater than the channel width. The detector can improve the analysis accuracy and reproducibility of the analysis device.
Abstract translation: 使用磁性颗粒的样品分析装置的问题是难以均匀地捕获磁性颗粒，特别是通道侧壁附近的均匀性差。 这导致分析精度差和重复性差。 本发明旨在提供在通道侧壁附近均匀地捕获磁性颗粒的方法。 具体而言，本发明提供一种分析装置，其具有检测通道，该检测通道具有入口和出口，通过该入口和出口将含有特定物质的样品液体和磁性颗粒流入和流出通道，以及磁场产生装置， 在检测通道的预定区域中的磁场的大小。 检测器中磁体的宽度大于通道宽度。 检测器可以提高分析装置的分析精度和再现性。
-
公开(公告)号：US11169168B2
公开(公告)日：2021-11-09
申请号：US16483799
申请日：2018-03-07
Applicant: Hitachi High-Technologies Corporation
Inventor： Taichiro Yamashita , Yoshihiro Yamashita , Takenori Okusa , Shunsuke Sasaki
Abstract: An automated analyzer includes a reagent container holder (2) including an openable and closable opening (23) and including a plurality of reagent container holding slots capable of holding reagent containers at internal predetermined positions, and loading assisting means (24) for executing a loading process of conveying the reagent container (3) from outside of the reagent container holder (2) into the reagent container holder (2) via the opening (23) to load the reagent container (3) into the reagent container holding slot (26) and a taking-out process of conveying the reagent container (3) from the reagent container holding slot (26) to outside of the reagent container holder (2) via the opening (23). The loading assisting means (24) is further provided with placing means (33) for the reagent container (3), and an operation handle (34) to be operated for driving the loading assisting means (24). Thus, an automated analyzer can be provided that allows a reagent replacing operation to be easily and reliably achieved.
-
公开(公告)号：US09958468B2
公开(公告)日：2018-05-01
申请号：US14901370
申请日：2014-07-25
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Yoshihiro Yamashita , Toshiharu Suzuki , Takaaki Hagiwara , Kazunori Yamazawa
CPC classification number: G01N35/0092 , G01N35/00712 , G01N35/00871 , G01N2035/00643 , G01N2035/00673 , G01N2035/0091 , G01N2035/0094
Abstract: The present invention provides an automatic analyzer capable of reducing the time necessary for analysis processing by making various operations pertaining to the analysis processing more efficient. More specifically, the present invention is characterized in that, from among a plurality of ending operation items set as analysis ending operations to perform at the end of analysis operations for analyzing a sample under analysis, one or more ending operation items to be performed are selected, and on the basis of monitoring results of monitoring the status of an automatic analyzer during the period from the end of the analysis ending operations to the start of analysis preparation operations for preparing for the analysis operations, one or more preparation operation items to be performed are selected from among a plurality of preparation operation items set as analysis preparation operations.
-
Patent Agency Ranking
6.发明申请ELECTROCHEMILUMINESCENCE METHOD OF DETECTING AN ANALYTE IN A LIQUID SAMPLE AND ANALYSIS SYSTEM 有权检测液体样品和分析系统中的分析仪的电致发光方法公开(公告)号：US20160097765A1
公开(公告)日：2016-04-07
申请号：US14968118
申请日：2015-12-14
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Kenichi Takahashi
IPC: G01N33/543 , G01N21/69
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
Abstract translation: 用于检测液体样品中的分析物的电化学发光法和相应的分析系统。 通过首先将含有包含蛋白质包被的磁性微粒的流体的容器提供到搅拌单元来检测液体样品中的分析物。 流体的搅拌是必需的，因为微粒的密度通常高于缓冲液的密度。 因此，由于弱相互作用，微粒倾向于沉积在容器的底部，导致微粒的聚集。 为了获得代表性的测量，需要在缓冲液中均匀分布微粒以确保每个分析循环的微粒的恒定浓度。 还需要提供微粒的解聚，这也是通过搅拌流体来实现的。 以适合于待搅拌的流体的量的转动频率进行搅拌。
-
公开(公告)号：US11320443B2
公开(公告)日：2022-05-03
申请号：US16477221
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroya Umeki , Kenta Imai , Yoshihiro Yamashita , Shunsuke Sasaki , Akihiro Endou
Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
-
公开(公告)号：US11293934B2
公开(公告)日：2022-04-05
申请号：US16307787
申请日：2017-04-24
Inventor： Takeshi Ishida , Sakuichiro Adachi , Yoshihiro Yamashita , Shunichirou Nobuki , Hisashi Yabutani , Isao Yamazaki , Michaela Windfuhr , Bernhard Hauptmann , Simon Kuester
Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.
-
公开(公告)号：US11161118B2
公开(公告)日：2021-11-02
申请号：US16477535
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroki Fujita , Toshiharu Suzuki , Takenori Okusa , Shunsuke Sasaki , Yoshihiro Yamashita , Kenta Imai
Abstract: The mixing of reagents with each other in the reagent storage flow paths of an automatic analyzer is suppressed before and after exchange of the reagents, which are capable of being replenished without stopping analysis. An exchangeable reagent container that accommodates a reagent is connected to a reagent storage flow path that stores a portion of the reagent. The reagent storage flow path has first and second flow paths in which the second flow path is branched from the first flow path. A reagent syringe applies a negative or a positive pressure to the first and second flow paths; and a valve controls the flow path through which the reagent is sent. As a result, the reagent supplied to a measurement portion at a predetermined timing is switched from the reagent container to the reagent storage flow path wherein the reagent can be supplied without stopping analysis.
-
公开(公告)号：US10753953B2
公开(公告)日：2020-08-25
申请号：US15550095
申请日：2016-01-07
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Reika Kuroda , Kenta Imai , Yukinori Sakashita , Yoshihiro Yamashita
Abstract: Provided are an automated analyzer for analyzing a substance contained in an unknown sample and a liquid reservoir, the analyzer and the reservoir being capable of saving users' operation without remarkably increasing the number of components. A flow path outlet of an overflow portion of the liquid reservoirs projects closer to the inner circumferential side of a drain flow path than to an inner circumferential surface side of an outer wall of the drain flow path serving as a destination to which liquid overflows. In addition, the flow path outlet projects so as to come into contact with an outer wall of the inner pipe. The flow path outlet of the overflow portion projects into the drain flow path so as to be located below an upper end of the outer wall of the drain flow path.
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.049 seconds)
