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    CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE
    2.
    发明申请
    CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE 有权
    液体分配盒，自动分析仪和分析生物样品的方法

    公开(公告)号：US20160139164A1

    公开(公告)日：2016-05-19

    申请号：US15006476

    申请日：2016-01-26

    Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

    Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke ,  Terumi Tamura ,  Taku Sakazume ,  Kyoko Imai

    IPC: G01N35/10 ,  B01L3/02

    CPC classification number: G01N35/1002 ,  B01L3/0268 ,  B01L3/0286 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  G01N35/1009

    Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

    Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体的储存室。 储存室具有流体出口。 墨盒还包括可控分配器部件，用于从储存室分配流体的分配体积。 分配器部件连接到储存器的流体出口。 墨盒还包括具有单个弹性抽吸元件的单个可压缩流体泵和从流体泵朝向流体出口延伸的导管。 当压缩弹性抽吸元件时，流体泵将流体的混合体积从管道排出到储存室中。 混合体积取决于弹性泵送元件的压缩程度。 当弹性抽吸元件减压时，流体泵从储存器吸入混合容积。

    BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE
    3.
    发明申请
    BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE 有权
    生物分子检测方法，生物分子检测装置和分析装置

    公开(公告)号：US20150308977A1

    公开(公告)日：2015-10-29

    申请号：US14418480

    申请日：2013-06-28

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Toshiro Saito ,  Kenta Imai ,  Kyoko Imai ,  Kazumichi Imai ,  Itaru Yanagi ,  Yoshimitsu Yanagawa ,  Masahiko Ando ,  Naoshi Itabashi

    IPC: G01N27/414 ,  G01N33/543

    CPC classification number: G01N27/4145 ,  G01N27/4148 ,  G01N33/48721 ,  G01N33/543 ,  G01N33/54306 ,  G01N37/00

    Abstract: The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.

    Abstract translation: 本发明旨在提供一种用于在宽动态范围内检测具有高灵敏度和高产量的生物分子的方法和装置，而不需要预先对样品进行浓度调节。 本发明将电荷载体特异性地结合到检测目标生物分子，并且通过测量随着生物分子和电荷载体的共轭体通过微孔而发生的电流变化逐个检测检测目标生物分子。 生物分子样品的高通量检测是可能的与一组检测器。

    Automatic analysis apparatus
    5.
    发明授权
    Automatic analysis apparatus 有权

    公开(公告)号：US10768189B2

    公开(公告)日：2020-09-08

    申请号：US15111195

    申请日：2015-01-09

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Kenta Imai ,  Yoshinori Negishi ,  Toshinari Sakurai ,  Kyoko Imai

    IPC: G01N35/00 ,  G01N27/416 ,  G01N27/49 ,  G01N35/10

    Abstract: When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.

    IMMUNOANALYSIS METHOD AND IMMUNOANALYSIS DEVICE
    6.
    发明申请
    IMMUNOANALYSIS METHOD AND IMMUNOANALYSIS DEVICE 有权
    免疫分析方法和免疫分析装置

    公开(公告)号：US20150212082A1

    公开(公告)日：2015-07-30

    申请号：US14418990

    申请日：2013-06-21

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Kyoko Imai ,  Toshiro Saito ,  Kazumichi Imai

    IPC: G01N33/543

    CPC classification number: G01N33/54386 ,  G01N21/6428 ,  G01N21/6452 ,  G01N33/54326 ,  G01N33/54366

    Abstract: An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.

    Abstract translation: 本发明的目的是提供高灵敏度的免疫分析方法和分析装置。 本发明涉及一种分析方法和分析装置，其以被测量成分与与其特异性反应的捕获成分反应，并且当待测量成分存在时，反应物被标记，并且其特征在于 通过将标记的反应物排列在空间上分离的某些位置并检测标记的反应物的标记物来分析单分子灵敏度和分辨率的待测组分。

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