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公开(公告)号：US20210085805A1
公开(公告)日：2021-03-25
申请号：US17027286
申请日：2020-09-21
发明人： Luke D. LAVIS , Qinsi ZHENG
IPC分类号： A61K49/00 , C07D311/04 , C07F7/08 , G01N21/64
摘要： The presently-disclosed subject matter includes fluorescent compounds of the following formula: The compounds can be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
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公开(公告)号：US20230038702A1
公开(公告)日：2023-02-09
申请号：US17940199
申请日：2022-09-08
发明人： Luke D. LAVIS , Claire DEO
IPC分类号： C07F7/08 , G01N21/78 , C07D405/14 , C07D405/04
摘要： The presently-disclosed subject matter includes fluorescent indicators, including bright and targetable red Ca2+ indicators. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
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公开(公告)号：US20200025769A1
公开(公告)日：2020-01-23
申请号：US16347765
申请日：2017-11-30
IPC分类号： G01N33/58 , C07K14/435 , C07K14/46 , C07K14/465 , C12N9/14 , C07K14/215 , G01N33/566 , C07K14/195 , G01N21/64
摘要： Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.
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公开(公告)号：US20190106573A1
公开(公告)日：2019-04-11
申请号：US16087864
申请日：2017-05-22
发明人： Luke D. LAVIS , Jonathan B. GRIMM
摘要： Provided are a photoactive fluorophore, a photoactive ligand, and a photoactive complex. The photoactive fluorophore includes a photoactivatable derivative of an azetidine-containing Janelia-Fluor dye. The photoactive ligand includes a photoactive fluorophore and a protein tag. The photoactive complex includes a photoactive ligand conjugated to a protein. Also provided are methods of in vivo labeling with and photoactivation of the photoactive fluorophore, ligand, and complex.
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公开(公告)号：US20230416320A1
公开(公告)日：2023-12-28
申请号：US18330459
申请日：2023-06-07
CPC分类号： C07K14/4728 , G01N33/582 , G01N33/84 , G01N21/77 , A61K49/0004 , A61K49/0041 , A61K49/0056 , C07K2319/20 , C07K2319/60 , G01N2333/4727 , G01N2021/7786
摘要： A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
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公开(公告)号：US20210054001A1
公开(公告)日：2021-02-25
申请号：US17001332
申请日：2020-08-24
发明人： Luke D. LAVIS , Claire DEO
IPC分类号： C07F7/08 , C07D405/04 , C07D405/14 , G01N21/78
摘要： The presently-disclosed subject matter includes fluorescent indicators, including bright and targetable red Ca2+ indicators. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
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公开(公告)号：US20180251441A1
公开(公告)日：2018-09-06
申请号：US15756788
申请日：2016-09-01
IPC分类号： C07D311/16 , C09K11/06 , C07D311/82 , C07D405/12 , C07D307/94 , A61K41/00 , A61N5/06 , G01N21/64
CPC分类号： C07D311/16 , A61K41/0057 , A61N5/06 , A61N5/062 , C07D307/94 , C07D311/82 , C07D405/12 , C09K11/06 , C09K2211/1022 , G01N21/6428 , G01N33/582 , G01N33/84 , G01N2021/6439
摘要： The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.
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公开(公告)号：US20220299518A1
公开(公告)日：2022-09-22
申请号：US17835535
申请日：2022-06-08
IPC分类号： G01N33/58 , C07K14/195 , C07K14/215 , C07K14/435 , C07K14/46 , C07K14/465 , C12N9/14 , G01N21/64 , G01N33/566
摘要： Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.
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公开(公告)号：US20210171490A1
公开(公告)日：2021-06-10
申请号：US17116987
申请日：2020-12-09
发明人： Luke D. LAVIS , Jonathan B. GRIMM
IPC分类号： C07D311/82 , C07C63/72 , C07F7/08 , C07D335/12 , C07F9/6568 , C07D409/14 , C07D413/10 , C07D405/14 , C07D491/147 , G01N21/64
摘要： A compound of the following structure is provided:
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公开(公告)号：US20200317743A1
公开(公告)日：2020-10-08
申请号：US16768153
申请日：2018-12-31
摘要： A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
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