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14 条记录 (耗时 0.02 秒)

    Theophylline and theobromine derivatives
    1.
    发明授权
    Theophylline and theobromine derivatives 失效
    茶碱和可可碱衍生物

    公开(公告)号：US4564617A

    公开(公告)日：1986-01-14

    申请号：US484044

    申请日：1983-04-11

    申请人： Hachiro Sugimoto ,  Takaharu Nakamura ,  Sachiyuki Hamazo ,  Yoshiharu Daiku

    发明人： Hachiro Sugimoto ,  Takaharu Nakamura ,  Sachiyuki Hamazo ,  Yoshiharu Daiku

    IPC分类号： C07D473/08 ,  C07D473/10 ,  A61K31/52

    CPC分类号： C07D473/10 ,  C07D473/08 ,  Y10S514/826 ,  Y10S514/929

    摘要： A novel compound has the following formula: ##STR1## in which R.sub.1 and R.sub.2 are methyl or a group having the formula: ##STR2## provided that one of R.sub.1 and R.sub.2 is methyl and the other is said group, wherein R stands for a hydrogen atom or a lower alkyl group, Z stands for a group ##STR3## in which X.sub.1 and X.sub.2, which may be the same or different, stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, or a pyridyl group or a group ##STR4## in which Y.sub.1 and Y.sub.2, which may be the same or different stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, X stands for a nitrogen or carbon atom, and n is an integer of from 2 to 10, provided that when R.sub.2 is the group having the formula II, X is not carbon and Z is not pyridyl.

    摘要翻译： 一种新型化合物具有下式：其中R 1和R 2为甲基或具有下式的基团的化合物：其中R1和R2之一为甲基，另一个为所述基团， 其中R代表氢原子或低级烷基，Z代表基团“IMAGE”，其中X1和X2可以相同或不同，代表氢原子，低级烷基，低级烷氧基 ，三氟甲基或卤素原子，或吡啶基或​​其中Y 1和Y 2可以相同或不同，代表氢原子，低级烷基，低级烷氧基，三氟甲基 基团或卤素原子，X表示氮原子或碳原子，n表示2〜10的整数，条件是当R 2为式II的基团时，X不为碳，Z为非吡啶基。

    Theophylline and theobromine derivatives
    2.
    发明授权
    Theophylline and theobromine derivatives 失效
    茶碱和可可碱衍生物

    公开(公告)号：US4426383A

    公开(公告)日：1984-01-17

    申请号：US298227

    申请日：1981-08-31

    申请人： Hachiro Sugimoto ,  Takaharu Nakamura ,  Sachiyuki Hamazo ,  Toshiji Igarashi ,  Yoshiharu Daiku

    发明人： Hachiro Sugimoto ,  Takaharu Nakamura ,  Sachiyuki Hamazo ,  Toshiji Igarashi ,  Yoshiharu Daiku

    IPC分类号： C07D473/08 ,  C07D473/10 ,  A61K31/52

    CPC分类号： C07D473/10 ,  C07D473/08 ,  Y10S514/826 ,  Y10S514/929

    摘要： A novel compound has the following formula: ##STR1## in which R.sub.1 and R.sub.2 are methyl or a group having the formula: ##STR2## provided that one of R.sub.1 and R.sub.2 is methyl and the other is said group, wherein R stands for a hydrogen atom or a lower alkyl group, Z stands for a group ##STR3## in which X.sub.1 and X.sub.2, which may be the same or different, stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, or a pyridyl group or a group ##STR4## in which Y.sub.1 and Y.sub.2, which may be the same or different stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, X stands for a nitrogen or carbon atom, and n is an integer of from 2 to 10, provided that when R.sub.2 is the group having the formula II, X is not carbon and Z is not pyridyl.

    摘要翻译： 一种新型化合物具有下式：其中R 1和R 2为甲基或具有下式的基团的化合物：其中R1和R2之一为甲基，另一个为所述基团， 其中R代表氢原子或低级烷基，Z代表基团“IMAGE”，其中X1和X2可以相同或不同，代表氢原子，低级烷基，低级烷氧基 ，三氟甲基或卤素原子，或吡啶基或​​其中Y 1和Y 2可以相同或不同，代表氢原子，低级烷基，低级烷氧基，三氟甲基 基团或卤素原子，X表示氮原子或碳原子，n表示2〜10的整数，条件是当R 2为式II的基团时，X不为碳，Z为非吡啶基。

    Piperidine derivative and pharmaceutical composition containing the same
    9.
    发明授权
    Piperidine derivative and pharmaceutical composition containing the same 失效
    哌啶衍生物和含有其的药物组合物

    公开(公告)号：US5179095A

    公开(公告)日：1993-01-12

    申请号：US798963

    申请日：1991-11-26

    申请人： Hitoshi Oinuma ,  Motosuke Yamanaka ,  Kazutoshi Miyake ,  Tomonori Hoshiko ,  Norio Minami ,  Tadao Shoji ,  Yoshiharu Daiku ,  Kohei Sawada ,  Kenichi Nomoto

    发明人： Hitoshi Oinuma ,  Motosuke Yamanaka ,  Kazutoshi Miyake ,  Tomonori Hoshiko ,  Norio Minami ,  Tadao Shoji ,  Yoshiharu Daiku ,  Kohei Sawada ,  Kenichi Nomoto

    IPC分类号： C07D211/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07D473/10

    CPC分类号： C07D401/04 ,  C07D211/28 ,  C07D401/06 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07D473/10

    摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sup.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, CH.sup.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,--(CH.sub.2)k--S--, k being an integer of 2 to 5, --(CH.sub.2)p--CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.

    摘要翻译： 新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢 低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢 ，低级烷基，低级烯基，氰基，CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，A为1或2，-AB，A为 - （CH 2）n - ，n为 1至5的整数，具有1至5个碳原子的直链亚烷基，其是衍生自直接与一个或多个碳原子键合的低级烷基，苯基或羟基的直链烷烃的二价基团 通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃，具有1至5个碳原子的直链亚烷基，其是 通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。