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1.发明申请公开(公告)号：US20100195203A1
公开(公告)日：2010-08-05
申请号：US12065778
申请日：2006-09-08
CPC分类号： G02B27/2214 , G02B3/005 , G02F1/1334 , G02F1/133707 , G02F1/133723 , G02F1/133784 , G02F1/29
摘要： A method of producing a lenticular device for an autostereoscopic display apparatus comprises providing a substrate having a surface which corresponds in shape to a desired surface profile for the array of lenticular elements, and providing an optical layer mixture of an optically birefringent material and a polymer precursor over the substrate surface. The optical layer is exposed to a stimulus for polymerizing the polymer precursor to have at least a polymer surface layer, thereby enclosing the material between the polymerized material and the surface to define lenticular elements. This method allows a simple polymerization process, forming a single layer, to complete the LC cell formation in the desired lenticular array shape.
摘要翻译： 一种用于自动立体显示装置的双凸透镜装置的制造方法包括提供具有对应于形状的表面的基板，用于双凸透镜元件阵列的期望表面轮廓，以及提供光学双折射材料和聚合物前体的光学层混合物 在基板表面上。 将光学层暴露于用于使聚合物前体聚合以具有至少聚合物表面层的刺激，从而将材料封闭在聚合材料和表面之间以限定透镜元件。 该方法允许简单的聚合过程，形成单层以完成所需透镜阵列形状的LC细胞形成。
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公开(公告)号：US10254553B2
公开(公告)日：2019-04-09
申请号：US12065778
申请日：2006-09-08
IPC分类号： G02B27/22 , G02B3/00 , G02F1/1334 , G02F1/29 , G02F1/1337
摘要： A method of producing a lenticular device for an autostereoscopic display apparatus includes providing a substrate having a surface which corresponds in shape to a desired surface profile for the array of lenticular elements, and providing an optical layer mixture of an optically birefringent material and a polymer precursor over the substrate surface. The optical layer is exposed to a stimulus for polymerizing the polymer precursor to have at least a polymer surface layer, thereby enclosing the material between the polymerized material and the surface to define lenticular elements. This method allows a simple polymerization process, forming a single layer, to complete the LC cell formation in the desired lenticular array shape.
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公开(公告)号：US09863006B2
公开(公告)日：2018-01-09
申请号：US14118570
申请日：2012-04-30
摘要： The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
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公开(公告)号：US09267109B2
公开(公告)日：2016-02-23
申请号：US12746767
申请日：2008-12-05
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2535/10 , C12N2539/10
摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.
摘要翻译： 本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。
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5.发明授权Microfluidic device and method of manufacturing the same and sensor incorporating the same 有权微流体装置及其制造方法及其结合的传感器公开(公告)号：US08475736B2
公开(公告)日：2013-07-02
申请号：US12746940
申请日：2008-12-08
IPC分类号： B01L3/00
CPC分类号： B01L3/5023 , B01L3/502753 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B01L2300/168 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , Y10T29/49826
摘要： The present invention provides a microfluidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
摘要翻译： 本发明提供了微流体装置，例如用于分子筛或用于检测样品流体中的目标物质。 该装置包括具有基本平坦的第一表面的第一基底（120），第一基底具有第一凹槽（124），第二基底（128）具有基本平坦的第二表面，该第二基底具有第二凹槽（130）。 至少一些第一凹部填充有多孔材料（114）。 替代的第一凹槽和第二凹槽形成用于样品流体的曲折通道。 第二凹部可以被另外的多孔材料填充。 在一个实施方案中，用于结合目标物质的捕获物质被布置在多孔材料中或其上。
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公开(公告)号：US20100124775A1
公开(公告)日：2010-05-20
申请号：US12523540
申请日：2008-01-18
申请人： Emiel Peeters , Dirk Jan Broer , Roel Penterman , Ralf Kurt , Steven Van Lierop
发明人： Emiel Peeters , Dirk Jan Broer , Roel Penterman , Ralf Kurt , Steven Van Lierop
CPC分类号： C12N5/0068 , C12N2533/30 , C12N2533/40
摘要： According to the present invention, a process for treating cultured cells is provided, which comprises the steps of: a) providing planar, two-dimensional objects (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, b) providing cells on said flakes, and c) transferring the flakes from the planar state into a rolled state by application of said extrinsic stimulus.
摘要翻译： 根据本发明，提供了一种处理培养细胞的方法，其包括以下步骤：a）提供平面的二维物体（“薄片”），其中这些物体包括在施加外在刺激物 从平面状态转移到轧制状态，b）在所述薄片上提供细胞，以及c）通过施加所述外部刺激将薄片从平面状态转移到滚动状态。
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公开(公告)号：US20090178929A1
公开(公告)日：2009-07-16
申请号：US12302923
申请日：2007-05-22
申请人： Dirk Jan Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
发明人： Dirk Jan Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
CPC分类号： G01N27/44795
摘要： The invention relates to a device for use in separation, especially isoelectric focusing employing “pH sink regions”, whereby the direction of change in pH is reversed.
摘要翻译： 本发明涉及一种用于分离的装置，特别是使用“pH沉降区”的等电聚焦，由此使pH变化的方向相反。
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公开(公告)号：US20080283400A1
公开(公告)日：2008-11-20
申请号：US12096918
申请日：2006-11-28
申请人： Dirk John Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
发明人： Dirk John Broer , Emiel Peeters , Ralph Kurt , Roel Penterman
CPC分类号： G01N27/44747 , B01D15/20 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J2220/54
摘要： The invention relates to a separation medium for chromatography which is structured in that way that the flow rate is in one preselected direction larger than perpendicular to that direction.
摘要翻译： 本发明涉及一种色谱分离介质，该分离介质以这种方式构成，即流速在垂直于该方向的一个预选方向上。
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公开(公告)号：US09291284B2
公开(公告)日：2016-03-22
申请号：US13980586
申请日：2012-01-20
CPC分类号： F16K51/00 , B01L3/502738 , B01L2300/0874 , B01L2300/0887 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/794
摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
摘要翻译： 本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。
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公开(公告)号：US20110293712A1
公开(公告)日：2011-12-01
申请号：US13132534
申请日：2009-11-26
申请人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
发明人： Ralph Kurt , Emiel Peeters , Roel Penterman , Dirk J. Broer , David Halter
CPC分类号： B01J13/04 , A61K2035/126 , A61L27/38 , A61L27/58
摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.
摘要翻译： 本发明提供了在单个细长隔室中的多个电池的同轴封装。 通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。 在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。
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