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1.发明授权Process for the determination of the hematocrit level of whole blood and apparatus for carrying out the process 失效用于确定全血的血细胞比容水平和进行该过程的装置的过程
公开(公告)号：US4835477A
公开(公告)日：1989-05-30
申请号：US86495
申请日：1987-08-14
IPC分类号： G01N33/49 , A61M1/36 , G01N27/02 , G01N27/06 , G01N27/416 , G01N33/487
CPC分类号： A61M1/3669 , A61M1/3609 , G01N33/492
摘要： There is described a method and apparatus for the determination of hematocrit levels in which both the conductivity of whole blood and the conductivity of blood plasma are determined together. While a conductivity cell (18) is being used for the determination of the conductivity of whole blood, the conductivity of plasma is calculated in a computer (30) with the aid of ion selective electrodes (14, 16) from the sodium or potassium concentrations.
摘要翻译： 描述了用于确定血细胞比容水平的方法和装置，其中全血的电导率和血浆的电导率都同时确定。 虽然电导率电池（18）被用于确定全血的电导率，但是在计算机（30）中借助离子选择电极（14,16）从钠或钾浓度计算出等离子体的电导率 。
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2.发明授权Measuring device for determination of the activity or of the concentration of ions in solutions 失效用于测定溶液中离子的活度或浓度的测量装置
公开(公告)号：US4797191A
公开(公告)日：1989-01-10
申请号：US732022
申请日：1985-05-08
申请人： Klaus Metzner , Detlef Westphal , Wolfgang Allendorfer , Reinhard Hahnel , Hans-Dietrich Polaschegg
发明人： Klaus Metzner , Detlef Westphal , Wolfgang Allendorfer , Reinhard Hahnel , Hans-Dietrich Polaschegg
IPC分类号： G01N27/416 , A61M1/14 , A61M1/16 , A61M1/36 , G01N27/28 , G01N27/403 , G01N33/48 , G01N35/00 , G01N27/26
CPC分类号： A61M1/3621 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/361 , A61M1/3612 , Y10T436/255
摘要： Measuring device for determination of the activity or of the concentration of ions in solutions, which has an electrode block having several electrodes and with a flow channel, the flow channel being in connection at its one end with a sample vessel and is connected at its other end to a line, in which a pump is interposed, with calibrating solution containers.Between the pump and the outlet of the electrode block branches off a discharge line, in which a further pump is interposed. Preferably, both pumps are combined into a peristaltic pump, the lines being laid in the segments of the pump.According to a second embodiment, the electrode block is again in connection with the calibrating solution containers. The delivery of the sample is performed however on the same side through a septum. Advantageously, the other side of the electrode block opens out into a pressure equalization vessel, into which a withdrawal line opens in which in turn the above mentioned peristaltic pump is interposed.
摘要翻译： 用于测定溶液中活性或离子浓度的测量装置，其具有具有多个电极和流动通道的电极块，所述流动通道在其一端与样品容器连接并且在另一端连接 在其中插入泵的管路与校准溶液容器结合。 在电极块的泵和出口之间分支一个排出管，其中插入另一个泵。 优选地，两个泵组合成蠕动泵，线路被放置在泵的段中。 根据第二实施例，电极块再次与校准溶液容器连接。 然而，通过隔膜在同一侧进行样品的输送。 有利地，电极块的另一侧向外打开压力平衡容器，抽出管线打开，其中插入上述蠕动泵。
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3.发明授权Apparatus for the drawing off of untreated and treated dialyzing liquid and/or blood from a dialysis device 失效用于从透析装置抽出未经处理和处理的透析液体和/或血液的装置
公开(公告)号：US4662208A
公开(公告)日：1987-05-05
申请号：US732025
申请日：1985-05-08
申请人： Klaus Metzner , Detlef Westphal , Wolfgang Allendorfer , Reinhard Hahnel , Hans-Dietrich Polaschegg
发明人： Klaus Metzner , Detlef Westphal , Wolfgang Allendorfer , Reinhard Hahnel , Hans-Dietrich Polaschegg
IPC分类号： G01N27/416 , A61M1/14 , A61M1/16 , A61M1/36 , G01N27/28 , G01N27/403 , G01N33/48 , G01N35/00 , B01D13/00 , G01N33/49
CPC分类号： A61M1/3621 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/361 , A61M1/3612 , Y10T436/255
摘要： An apparatus (1) for the drawing off of untreated and treated dialyzing liquid and/or blood from a dialysis device (1) has a dialyzer, from which a first line (22) goes off upstream and a second line (24) goes off downstream, which join into a third line (54). The third line (54) is connected to an analysis device (57). In each of the first and second lines is provided a pump (26, 28) and a shut-off element (56, 56'), between which an overflow (38, 40) per line is arranged. This on the one hand ensures that the liquid in the lines (22, 24) are kept constantly in motion, which prevents the formation of line blockages in the case of liquids tending to coagulate, and on the other hand considerably reduces the displacement time of the liquid to be investigated to the analysis device (57).
摘要翻译： 用于从透析装置（1）中抽出未处理和处理的透析液体和/或血液的装置（1）具有透析器，第一管线（22）从该透析器从上游流出，第二管线（24）从该透析器脱离 下游，加入第三行（54）。 第三线（54）连接到分析装置（57）。 在每个第一和第二管路中设置有泵（26,28）和截止元件（56,56'），每条线路之间布置有溢流（38,40）。 这一方面确保了管线（22,24）中的液体保持恒定运动，这防止在液体趋于凝结的情况下形成管线堵塞，另一方面大大减少了 待分析液体（57）。
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公开(公告)号：US09295773B2
公开(公告)日：2016-03-29
申请号：US13884115
申请日：2011-11-09
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M39/02 , A61M2039/0258 , A61M2039/027 , A61M2039/0285 , A61M2039/0288 , A61M2039/0291 , A61M2039/0294 , A61M2205/582 , A61M2207/00
摘要： A medical blood access system used for hemodialysis treatment to enable blood withdrawal for processing of blood by an external apparatus and return the same blood to a patient, comprising an interfacial fluid conduit between the machine and patient's blood supply which is repeatedly connectable along a guided pathway passing through epidermis and subcutaneous tissue via a naturally formed tissue tract to enter blood space, providing improved patient safely, convenience, effective prophylaxis, without bleeding or tissue trauma or pain, and is executable by the patient to precisely connect and disconnect with minimal disfigurement or life restrictions, and is useable on virtually all patients soon after placement and is robust and safe to high blood flow.
摘要翻译： 一种用于血液透析治疗的医用血液存取系统，用于通过外部设备进行血液处理以取出血液，并将相同的血液返回给患者，其包括在机器和患者的血液供应之间的界面流体导管，其可沿导向路径反复连接 通过表皮和皮下组织经由天然形成的组织管道进入血液空间，提供改善的患者安全，方便，有效的预防，没有出血或组织创伤或疼痛，并且可由患者执行以最小化的形态精确连接和断开， 寿命限制，并且几乎所有患者在放置后不久可以使用，并且对于高血流量是稳健和安全的。
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5.发明申请公开(公告)号：US20100145252A1
公开(公告)日：2010-06-10
申请号：US12460787
申请日：2009-07-24
CPC分类号： A61M25/0017 , A01N43/88 , A61K31/549 , A61K38/38 , A61K47/32 , A61L2/16 , A61L29/126 , A61M1/3661 , A61M2025/0056
摘要： Catheters used for medical treatment, e.g., hemodialysis are filled with a locking solution, usually heparin between treatments. To prevent infections, antimicrobial or antibiotic substances have been used as locking solution alone or in combination with antithrombotic substances. It has been found that these locking solutions are rapidly washed out from the catheter tip. The invention describes a thixotropic gel that can be used as locking solution. Beneficial substances, e.g., antimicrobial or antibiotic substances can be added to the gel. A preferred antimicrobial substance is taurolidin alone or in combination with salicylic acid or one of its salts.
摘要翻译： 用于医疗，例如血液透析的导管填充有锁定溶液，通常在治疗之间是肝素。 为了防止感染，抗微生物剂或抗生素物质已被用作单独的锁定溶液或与抗血栓形成物质组合使用。 已经发现这些锁定溶液从导管末端快速洗出。 本发明描述了可用作锁定溶液的触变凝胶。 可以将有益物质，例如抗微生物剂或抗生素物质加入到凝胶中。 优选的抗微生物物质是单独的taurolidin或与水杨酸或其盐之一组合。
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6.发明授权公开(公告)号：US07311689B2
公开(公告)日：2007-12-25
申请号：US10642638
申请日：2003-08-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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公开(公告)号：US06803363B2
公开(公告)日：2004-10-12
申请号：US10160529
申请日：2002-05-31
IPC分类号： A61K3154
CPC分类号： A61K31/19 , A61K31/549 , A61M1/287
摘要： The present invention contemplates the addition of 0.5% to 4% taurolidine into solutions used peritoneal dialysis. The taurolidine is intended to prevent or reduce the incidence of infection within the abdomen and/or in the vicinity of an implanted dialysis port. The invention also includes methods using solutions of taurolidine in the flushing and locking of catheters and fluid lines used in peritoneal dialysis.
摘要翻译： 本发明考虑将0.5％至4％的taurolidine加入到腹膜透析溶液中。 该taurolidine旨在防止或减少在腹部和/或植入的透析口附近的感染的发生率。 本发明还包括使用taurolidine的溶液在用于腹膜透析的导管和流体管线的冲洗和锁定中的方法。
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8.发明授权公开(公告)号：US06575945B2
公开(公告)日：2003-06-10
申请号：US10140630
申请日：2002-05-08
IPC分类号： A61M3100
CPC分类号： A61L29/16 , A61L27/54 , A61L2300/104 , A61L2300/204 , A61L2300/404 , A61M39/0208
摘要： An improvement in an implantable port of the type including a housing that is implanted within a subcutaneous tissue pocket is disclosed, wherein the improvement comprises the presence of metallic silver, an inorganic silver compound, a silver salt of an organic acid, or other antimicrobial substances such as taurolidine on the surfaces of the port in contact with, or proximate to, the tissue of said pocket.
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公开(公告)号：US4997570A
公开(公告)日：1991-03-05
申请号：US431555
申请日：1989-11-03
CPC分类号： A61M1/16 , A61M1/1639 , Y10S210/929
摘要： A method and a device for ultrafiltration during hemodialysis are described in which ultrafiltrate fluid, before removal from the dialysis circuit, is passed through a balancing device, which is also used as ultrafiltrate pump. For this purpose, a controller controls and actuates inlet, outlet, and dialyzer valves, in such a way that a desired amount of ultrafiltrate, corresponding to the filling volume of a balancing chamber or a multiple thereof, is introduced to the discharge through the balancing chamber. In order to carry out continuous ultrafiltration during hemodialysis, a predetermined amount of air is introduced to the dialysis fluid flow circuit through an air separator and is then pumped off during hemodialysis so that a corresponding amount of ultrafiltrate is obtained.
摘要翻译： 描述了在血液透析期间用于超滤的方法和装置，其中在从透析回路移除之前的超滤液通过平衡装置，该平衡装置也用作超滤泵。 为此，控制器控制和致动入口，出口和透析器阀，使得对应于平衡室的填充体积或其倍数的期望量的超滤液通过平衡被引入到排出口 房间。 为了在血液透析期间进行连续超滤，通过空气分离器将预定量的空气引入透析流体回路中，然后在血液透析期间被泵送，从而获得相应量的超滤液。
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10.发明授权
公开(公告)号：US4844871A
公开(公告)日：1989-07-04
申请号：US047648
申请日：1987-05-08
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1495 , G01N33/49 , G01N33/497
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/14557 , G01N33/491 , Y10T436/11 , Y10T436/117497 , Y10T436/255
摘要： A method and an apparatus are described for determining the partial pressures of gases in blood, in which a membrane filter is used to separate plasma which passes to a blood gas analyzer.
摘要翻译： 描述了一种用于确定血液中气体分压的方法和装置，其中使用膜过滤器来分离通过血液分析仪的血浆。
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