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1.发明授权Treatment of neurological disorders via electrical stimulation, and methods related thereto 有权通过电刺激治疗神经系统疾病，以及与之相关的方法公开(公告)号：US09381346B2
公开(公告)日：2016-07-05
申请号：US12319158
申请日：2009-01-02
申请人： Harry Lee , Allan Foreman , Wolfgang Daum , Richard Cohen , Jean Gotman , Andrew James Cole
发明人： Harry Lee , Allan Foreman , Wolfgang Daum , Richard Cohen , Jean Gotman , Andrew James Cole
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： The present invention features a medical device and methods for the prevention and/or treatment of neurological disorders via electrical stimulation. These device are minimally or non-invasive and are capable of detection of a neurological disorder and its subsequent prevention or treatment. Specifically, seizure control is among the targeted therapeutic areas. Components of the device include control electronics and electrodes; the latter are targeting electrodes located entirely outside the skull and can be constructed from ring type structures or virtually connected disc type arrays. Other sub-systems included in the medical device are a control system, a battery unit, and wires connecting these and other sub-systems.
摘要翻译： 本发明的特征在于用于通过电刺激预防和/或治疗神经障碍的医疗装置和方法。 这些装置是最低限度的或非侵入性的，并且能够检测到神经障碍及其随后的预防或治疗。 具体来说，癫痫发作控制是目标治疗领域之一。 器件的组件包括控制电子器件和电极; 后者是靶向完全在颅骨外部的电极，并且可以由环形结构或虚拟连接的盘型阵列构成。 包括在医疗装置中的其他子系统是控制系统，电池单元和连接这些和其它子系统的电线。
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2.发明申请Treatment of neurological disorders via electrical stimulation, and methods related thereto 有权通过电刺激治疗神经系统疾病，以及与之相关的方法公开(公告)号：US20110137381A1
公开(公告)日：2011-06-09
申请号：US12319158
申请日：2009-01-02
申请人： Harry Lee , Allan Foreman , Wolfgang Daum , Richard Cohen , Jean Gotman , Andrew James Cole
发明人： Harry Lee , Allan Foreman , Wolfgang Daum , Richard Cohen , Jean Gotman , Andrew James Cole
IPC分类号： A61N1/37
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Disclosed are medical devices for the prevention and/or treatment of neurological disorders via electrical stimulation, and methods related thereto. The devices may also be utilized to detect disorders before the prevention or treatment of a neurological disorder. These devices are minimally or non-invasive. The present medical devices comprise various components, which include electrodes and control electronics. The electrodes are targeting electrodes constructed from ring type structures or virtually connected disc type arrays. The electrodes are located entirely outside the skull. The present medical devices also comprise one or more subsystems, a control system, a battery unit, and wires connecting the one or more subsystems. These devices may also be used for acute seizure control.
摘要翻译： 公开了用于通过电刺激预防和/或治疗神经障碍的医疗装置，以及与之相关的方法。 该装置还可用于在预防或治疗神经障碍之前检测病症。 这些装置是最小的或非侵入性的。 本医疗装置包括各种部件，包括电极和控制电子装置。 电极是由环形结构或虚拟连接的盘型阵列构成的靶向电极。 电极完全位于头骨外面。 本医疗设备还包括一个或多个子系统，控制系统，电池单元以及连接所述一个或多个子系统的电线。 这些装置也可用于急性发作控制。
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3.发明授权Devices for targeted delivery of thermotherapy, and methods related thereto 失效用于靶向递送热疗的装置，以及与之相关的方法公开(公告)号：US07951061B2
公开(公告)日：2011-05-31
申请号：US11258598
申请日：2005-10-25
申请人： Allan Foreman , Wolfgang Daum
发明人： Allan Foreman , Wolfgang Daum
IPC分类号： A61N2/00
摘要： Disclosed are devices for targeted delivery of thermotherapy. These devices are useful in the treatment of diseased tissue in conjunction with magnetic compositions. Further disclosed are methods for treating diseased tissue, which involve the administration of a thermotherapeutic magnetic composition to a patient or a portion of a patient, and the application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. The devices and the methods disclosed herein are useful for the treatment of a variety of indications, such as cancer, diseases of the immune system, pathogen-borne diseases, hormone-related diseases, non-cancerous diseased cells or tissue, and undesirable matter, such as toxins and reaction-by-products associated with organ transplants.
摘要翻译： 公开了用于靶向递送热疗的装置。 这些装置可用于结合磁性组合物治疗患病组织。 进一步公开的是用于治疗患病组织的方法，其涉及向患者或患者的一部分施用热治疗性磁性组合物，以及施加交变磁场以感应加热热治疗性磁性组合物。 本文公开的装置和方法可用于治疗各种适应症，例如癌症，免疫系统疾病，病原体传播疾病，激素相关疾病，非癌性病变细胞或组织，以及不期望的物质， 例如与器官移植相关的毒素和副产物。
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公开(公告)号：US20050090732A1
公开(公告)日：2005-04-28
申请号：US10696399
申请日：2003-10-28
申请人： Robert Ivkov , Wolfgang Daum , Allan Foreman , Douglas Gwost
发明人： Robert Ivkov , Wolfgang Daum , Allan Foreman , Douglas Gwost
摘要： Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance. The disclosed therapies may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, epitheleoid sarcomas, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, cardiovascular plaque, vascular plaque, obesity, malaria, and illnesses due to viruses, such as HIV.
摘要翻译： 公开了用于治疗受试者的身体，身体部位，组织，体液细胞，病原体或涉及施用靶向热疗法的其它不期望的物质的组合物，系统和方法，其包括生物探针（附着于靶 - 特异性配体）。 这样的靶向治疗方法可以与至少一种其它治疗技术组合。 其他疗法包括热疗，直接抗体治疗，放射治疗，化疗或药物治疗，光动力疗法，手术或介入治疗，骨髓或干细胞移植，以及医学成像，如MRI，PET，SPECT和生物阻抗。 所公开的疗法可用于治疗各种适应症，包括但不限于任何类型的癌症，例如骨髓，肺，血管，神经，结肠，卵巢，乳腺和前列腺癌，上皮样肉瘤，AIDS ，不良血管生成，再狭窄，淀粉样变性，结核病，心血管斑块，血管斑块，肥胖症，疟疾和由于病毒如HIV引起的疾病。
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5.发明申请Devices for targeted delivery of thermotherapy, and methods related thereto 失效用于靶向递送热疗的装置，以及与之相关的方法公开(公告)号：US20060142748A1
公开(公告)日：2006-06-29
申请号：US11258598
申请日：2005-10-25
申请人： Allan Foreman , Wolfgang Daum
发明人： Allan Foreman , Wolfgang Daum
摘要： Disclosed are devices for targeted delivery of thermotherapy. These devices are useful in the treatment of diseased tissue in conjunction with magnetic compositions. Further disclosed are methods for treating diseased tissue, which involve the administration of a thermotherapeutic magnetic composition to a patient or a portion of a patient, and the application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. The devices and the methods disclosed herein are useful for the treatment of a variety of indications, such as cancer, diseases of the immune system, pathogen-borne diseases, hormone-related diseases, non-cancerous diseased cells or tissue, and undesirable matter, such as toxins and reaction-by-products associated with organ transplants.
摘要翻译： 公开了用于靶向递送热疗的装置。 这些装置可用于结合磁性组合物治疗患病组织。 进一步公开的是用于治疗患病组织的方法，其涉及向患者或患者的一部分施用热治疗性磁性组合物，以及施加交变磁场以感应加热热治疗性磁性组合物。 本文公开的装置和方法可用于治疗各种适应症，例如癌症，免疫系统疾病，病原体传播疾病，激素相关疾病，非癌性病变细胞或组织，以及不期望的物质， 例如与器官移植相关的毒素和副产物。
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公开(公告)号：US09828010B2
公开(公告)日：2017-11-28
申请号：US12270160
申请日：2008-11-13
申请人： Tom Otsubo , Wolfgang Daum , Craig Alan Stull , Gregory Hann , Phillip Danner
发明人： Tom Otsubo , Wolfgang Daum , Craig Alan Stull , Gregory Hann , Phillip Danner
CPC分类号： B61L3/006
摘要： A mission planner system for a powered system, the mission planner system including a receiving device to collect aspect information as the powered system performs a mission, said aspect information being received from a remote location, a processor to determine a speed limit based at least in part on the aspect information, and a control system connected to the powered system to operate the powered system in response to the speed limit. A method and a computer software code for determining the mission plan with aspect information obtained from a remote location during the mission are also disclosed.
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7.发明授权System, method, and computer software code for providing an auxiliary communication path when a primary communication path is unavailable 有权用于在主通信路径不可用时提供辅助通信路径的系统，方法和计算机软件代码公开(公告)号：US09419816B2
公开(公告)日：2016-08-16
申请号：US12212079
申请日：2008-09-17
CPC分类号： H04L12/40189 , B61L15/0027 , H04L69/40 , H04L2012/40293
摘要： A method for communicating on a train that has at least two locomotives, the method including determining when a primary communication path ceases to be available for a specific subsystem of the train, identifying at least one auxiliary communication path to transmit information for the specific subsystem, configuring a message for the specific subsystem which complies with a message format of the at least one auxiliary communication path, and transmitting the message on the at least one auxiliary communication path. A system and a computer software code are further disclosed for providing a communication system for a powered system.
摘要翻译： 一种用于在具有至少两个机车的列车上进行通信的方法，所述方法包括确定主通信路径何时停止对于列车的特定子系统可用，识别至少一个辅助通信路径以传送特定子系统的信息， 配置符合所述至少一个辅助通信路径的消息格式的特定子系统的消息，以及在所述至少一个辅助通信路径上发送所述消息。 还公开了一种用于为动力系统提供通信系统的系统和计算机软件代码。
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8.发明授权System and method for managing an amount of stored energy in a powered system 有权用于管理动力系统中存储的能量的系统和方法公开(公告)号：US09233622B2
公开(公告)日：2016-01-12
申请号：US12137090
申请日：2008-06-11
CPC分类号： B60L11/1851 , B60L15/2045 , B60L2200/26 , B60L2260/54 , B60W10/24 , B60W30/14 , B60W50/04 , B60W2050/0062 , Y02T10/645 , Y02T10/7005 , Y02T10/705 , Y02T10/7283
摘要： A system is provided for managing an amount of stored energy in a powered system. The powered system is configured to complete a mission from an initial stage to a final stage. The system includes a controller including a memory configured to store a plurality of handling stages. The controller is configured to determine the stored energy at the initial stage based upon the initial stage and a handling stage positioned between the initial stage and the final stage, and selected from among the plurality of handling stages stored in memory. The stored energy is necessary to propagate the powered system from the initial stage to the handling stage upon the occurrence of an anomaly in the powered system. Additionally, a method and computer readable media are provided for managing an amount of stored energy in a powered system.
摘要翻译： 提供了一种用于管理动力系统中的存储能量的系统。 动力系统被配置为完成从初始阶段到最终阶段的任务。 该系统包括控制器，其包括被配置为存储多个处理级的存储器。 控制器被配置为基于初始阶段和位于初始阶段和最后阶段之间并且从存储在存储器中的多个处理阶段中选择的处理阶段来确定初始阶段的存储能量。 在动力系统发生异常时，存储的能量对于将动力系统从初始阶段传播到处理阶段是必要的。 另外，提供了一种用于管理动力系统中的存储能量的方法和计算机可读介质。
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9.发明授权System, method, and computer software code for providing real time optimization of a mission plan for a powered system 有权用于为动力系统提供任务计划的实时优化的系统，方法和计算机软件代码公开(公告)号：US08788135B2
公开(公告)日：2014-07-22
申请号：US12365359
申请日：2009-02-04
申请人： Wolfgang Daum , Ajith Kuttannair Kumar , Glenn Robert Shaffer , Joseph Forrest Noffsinger , Robert James Foy , David Lowell McKay
发明人： Wolfgang Daum , Ajith Kuttannair Kumar , Glenn Robert Shaffer , Joseph Forrest Noffsinger , Robert James Foy , David Lowell McKay
CPC分类号： B61L3/006
摘要： A method for operating a powered system, the method including determining whether a mission plan of the powered system is correct to satisfy at least one mission objective of the powered system, if not, updating information used to establish the mission plan, revising the mission plan based on the updated information to satisfy the at least one mission objective, and operating the powered system based on the revised mission plan. A system and a computer software code for operating a powered system are also disclosed.
摘要翻译： 一种用于操作动力系统的方法，所述方法包括确定所述动力系统的任务计划是否正确以满足所述动力系统的至少一个任务目标，如果不是，更新用于建立任务计划的信息，修改任务计划 基于更新的信息来满足至少一个任务目标，并且基于经修改的任务计划来操作动力系统。 还公开了用于操作动力系统的系统和计算机软件代码。
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10.发明授权公开(公告)号：US08370006B2
公开(公告)日：2013-02-05
申请号：US11608066
申请日：2006-12-07
CPC分类号： B61C17/12 , B61L3/006 , B61L25/021 , B61L25/025 , B61L25/026 , B61L27/0027 , B61L2205/04 , G05B13/021
摘要： One embodiment of the invention includes a system for operating a railway network comprising a first railway vehicle (400) during a trip along track segments (401/412/420). The system comprises a first element (65) for determining travel parameters of the first railway vehicle (400), a second element (65) for determining travel parameters of a second railway vehicle (418) relative to the track segments to be traversed by the first vehicle during the trip, a processor (62) for receiving information from the first (65) and the second (65) elements and for determining a relationship between occupation of a track segment (401/412/420) by the second vehicle (418) and later occupation of the same track segment by the first vehicle (400) and an algorithm embodied within the processor (62) having access to the information to create a trip plan that determines a speed trajectory for the first vehicle (400), wherein the speed trajectory is responsive to the relationship and further in accordance with one or more operational criteria for the first vehicle (400).
摘要翻译： 本发明的一个实施例包括一种用于在沿着轨道段（401/412/420）跳闸期间操作包括第一轨道车辆（400）的铁路网络的系统。 该系统包括用于确定第一铁路车辆（400）的行驶参数的第一元件（65），用于确定第二铁路车辆（418）相对于由所述轨道段穿过的轨道段的行驶参数的第二元件（65） 在行程期间的第一车辆，用于从第一（65）和第二（65）元件接收信息并且用于确定第二车辆的轨道段（401/412/420）的占用之间的关系的处理器（62） 418），并且随后由第一车辆（400）占据相同的轨道段，以及在处理器（62）内体现的具有访问该信息以创建确定第一车辆（400）的速度轨迹的行程计划的算法， 其中所述速度轨迹响应于所述关系，并且还根据所述第一车辆（400）的一个或多个操作标准。
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