-
公开(公告)号：US4745059A
公开(公告)日：1988-05-17
申请号：US749465
申请日：1985-06-27
申请人： Hartmut Voelskow , Reinhold Keller , Merten Schlingmann , Martin Platen , Johann Then , Gerhard Wohner
发明人： Hartmut Voelskow , Reinhold Keller , Merten Schlingmann , Martin Platen , Johann Then , Gerhard Wohner
CPC分类号： C12P13/222
摘要： L-Phenylalanine can be prepared using microorganisms belonging to the series comprising E. coli, Paracoccus denitrificans, Torula, Rhodotorula or Streptomyces after adaptation to phenylpyruvic acid, by amination with suitable sources of nitrogen. It is advantageous to employ the microorganism in the form of fixed cells.
摘要翻译： 可以通过用合适的氮源胺化，使用属于包含大肠杆菌，反硝化副球菌，Torula，Rhodotorula或Streptomyces的系列的微生物在适应苯丙酮酸之后制备L-苯丙氨酸。 使用固定细胞形式的微生物是有利的。
-
公开(公告)号：US5091314A
公开(公告)日：1992-02-25
申请号：US566322
申请日：1990-08-13
申请人： Rudiger Marquardt , Johann Then , Hans-Matthias Deger , Gerhard Wohner , Martyn K. Robinson , Andrew Doherty
发明人： Rudiger Marquardt , Johann Then , Hans-Matthias Deger , Gerhard Wohner , Martyn K. Robinson , Andrew Doherty
CPC分类号： C12N9/1096 , C12P13/222 , Y10S435/849
摘要： The isolation of the tyrB gene contained in E. coli ATCC 11303 and its cloning onto a multicopy plasmid results in a 10-fold increase in the L-phenylalanine yield after the transformation of the starting strain with this plasmid.
摘要翻译： 大肠杆菌ATCC 11303中所含的tyrB基因的分离及其在多拷贝质粒上的克隆导致用该质粒转化起始菌株后，L-苯丙氨酸产量增加10倍。
-
公开(公告)号：US5120654A
公开(公告)日：1992-06-09
申请号：US566320
申请日：1990-08-13
申请人： Rudiger Marquardt , Johann Then , Hans-Matthias Deger , Gerhard Wohner , Martyn K. Robinson , Evelyn L. K. Doherty
发明人： Rudiger Marquardt , Johann Then , Hans-Matthias Deger , Gerhard Wohner , Martyn K. Robinson , Evelyn L. K. Doherty
CPC分类号： C12N9/1096 , C12P13/06 , C12P13/08 , Y10S435/849
摘要： The ilvE gene from the strain E. coli ATCC 11303 is suitable for achieving overproduction of the coded aliphatic transaminase and thus for preparing the branched-chain amino acids leucine, isoleucine and valine from the corresponding keto precursors.
摘要翻译： 来自大肠杆菌ATCC11303菌株的ilvE基因适用于实现编码的脂肪族转氨酶的过量产生，并因此用于从相应的酮前体制备支链氨基酸亮氨酸，异亮氨酸和缬氨酸。
-
4.发明授权Process for preparing L-tertiary-Leucine and L-phosphinothricine by transamination 失效通过转氨酶制备L-三 - 亮氨酸和L-膦丝菌素的方法
公开(公告)号：US5753470A
公开(公告)日：1998-05-19
申请号：US411072
申请日：1995-03-27
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465
CPC分类号： C12P13/06 , C12N9/1096 , C12P13/04
摘要： L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
摘要翻译： 通过在作为氨基供体的氨基酸存在下作为前体的相应酮酸的氨基转移可获得L-叔亮氨酸和L-膦酰四氢叶酸。 该反应优选用微生物或其转氨酶进行。
-
5.发明授权Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and N-(4-trifluoromethylphenyl)2-cyano-3-hydroxycrotonic acid amide 有权含有5-甲基异恶唑-4-羧酸 - （4-三氟甲基） - 苯胺和N-（4-三氟甲基苯基）-2-氰基-3-羟基巴豆酸酰胺公开(公告)号：US07071222B2
公开(公告)日：2006-07-04
申请号：US09101672
申请日：1997-03-07
申请人： Robert Bartlett , Johann Then
发明人： Robert Bartlett , Johann Then
IPC分类号： A61K31/42 , A61K31/275
CPC分类号： C07D261/18 , A61K31/42 , A61K31/275 , A61K2300/00
摘要： A solid composition comprising 5-methyl-4′-trifluoromethyl-4-isoxazole carboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonic acid amide, suitable for treatment of immunological and cancerous diseases.
摘要翻译： 包含5-甲基-4'-三氟甲基-4-异恶唑甲酰苯胺和N-（4-三氟甲基苯基）-2-氰基-3-羟基巴豆酸酰胺的固体组合物，适用于治疗免疫学和癌性疾病。
-
6.发明授权Process for the preparation of L-phosphinothricin using transaminases of different specificities in a linked process 失效在连锁过程中使用不同特异性的转氨酶制备L-膦丝菌素的方法
公开(公告)号：US5587319A
公开(公告)日：1996-12-24
申请号：US272286
申请日：1994-07-08
申请人： Johann Then , Werner Aretz , Klaus Sauber
发明人： Johann Then , Werner Aretz , Klaus Sauber
CPC分类号： C12P13/04 , C12P41/006
摘要： L-2-Amino-4-methylphosphinobutyric acid can be prepared by a racemate resolution in the presence of D-aminoacid and L-aminoacid transaminases by reaction with .alpha.-keto acids and amino-group donors. In particular, transaminases from Bacillus licheniformis and from Escherichia coli are used.
摘要翻译： L-2-氨基-4-甲基膦酰基丁酸可以通过在α-氨基酸和L-氨基酸转氨酶的存在下通过与α-酮酸和氨基供体的反应通过外消旋体拆分制备。 特别地，使用来自地衣芽孢杆菌和大肠杆菌的转氨酶。
-
公开(公告)号：US5919669A
公开(公告)日：1999-07-06
申请号：US466697
申请日：1995-06-06
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465 , C12N15/74 , C12N15/78
CPC分类号： C12P13/06 , C12N9/1096 , C12P13/04
摘要： L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
-
8.发明授权Process for preparing L-tertiary-leucine and L-phosphinothricine by transamination 失效通过转氨酶制备L-三聚亮氨酸和L-膦丝菌素的方法
公开(公告)号：US5962281A
公开(公告)日：1999-10-05
申请号：US466696
申请日：1995-06-06
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/10 , C12N15/00 , C12N15/54 , C12P13/04 , C12P13/06 , C12R1/01 , C12R1/05 , C12R1/185 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/465
CPC分类号： C12P13/06 , C12N9/1096 , C12P13/04
摘要： L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
摘要翻译： 通过在作为氨基供体的氨基酸存在下作为前体的相应酮酸的氨基转移可获得L-叔亮氨酸和L-膦酰四氢叶酸。 该反应优选用微生物或其转氨酶进行。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.025 秒)
