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12 条记录 (耗时 0.027 秒)

    Method of treating cystic fibrosis
    2.
    发明授权
    Method of treating cystic fibrosis 失效
    囊性纤维化的治疗方法

    公开(公告)号：US6083954A

    公开(公告)日：2000-07-04

    申请号：US114537

    申请日：1998-07-13

    申请人： Harvey B. Pollard ,  Kenneth A. Jacobson

    发明人： Harvey B. Pollard ,  Kenneth A. Jacobson

    IPC分类号： G01N33/566 ,  A61K31/52 ,  A61K31/522 ,  A61K38/00 ,  A61K38/17 ,  A61P11/00 ,  A61P43/00 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08 ,  C07D473/12 ,  C07H21/00 ,  C07K14/47 ,  C12N15/09

    CPC分类号： A61K31/52 ,  C07D473/04 ,  C07K14/4712 ,  A61K38/00

    摘要： The present invention provides a method of identifying CFTR-binding compounds for treating cells having a reduced apical Cl.sup.- conductance, such as cystic fibrosis cells. This identification method involves the use of polypeptide I.alpha., which constitutes a portion of the CFTR protein. The present invention also provides a method of treating CF cells by contacting cells having a reduced apical Cl.sup.- conductance with a therapeutically effective quantity of a compound selected by the present inventive identification method. Preferred compounds for such treatment have little or no affinity for adenosine cell receptors. The present invention provides novel compounds useful in practicing the present inventive method, as well as pharmaceutical compositions containing such compounds.

    摘要翻译： 本发明提供了一种鉴定用于治疗具有降低的顶端Cl-电导的细胞的CFTR结合化合物的方法，例如囊性纤维化细胞。 该鉴定方法涉及使用构成CFTR蛋白的一部分的多肽Iα。 本发明还提供了通过使具有降低的顶端C1电导的细胞与治疗有效量的本发明鉴定方法选择的化合物接触来治疗CF细胞的方法。 用于这种治疗的优选化合物对腺苷细胞受体几乎没有或没有亲和力。 本发明提供了可用于实施本发明方法的新化合物，以及含有这些化合物的药物组合物。

    Method for treating hemophilia A and B and AIDS and devices used therein
    5.
    发明授权
    Method for treating hemophilia A and B and AIDS and devices used therein 有权
    治疗A型和B型血友病的方法及其中使用的装置

    公开(公告)号：US06174299B1

    公开(公告)日：2001-01-16

    申请号：US09205964

    申请日：1998-12-04

    申请人： Harvey B. Pollard ,  Bette S. Pollard

    发明人： Harvey B. Pollard ,  Bette S. Pollard

    IPC分类号： A61M3700

    CPC分类号： B01D69/02 ,  A61M1/1678 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3486 ,  A61M2202/0449 ,  A61M2202/0452 ,  Y10S436/811 ,  A61M2202/0035 ,  A61M2202/0078

    摘要： The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive Factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber. The present invention also provides a method for treating Hemophilia A or B extracorporeally. The present invention further provides methods for treating AIDS as well as permeable membranes for use in the methods above.

    摘要翻译： 本发明提供了一种治疗血友病A或B的方法，其包括与需要这种治疗的哺乳动物的血液流体连通地植入，该渗透膜具有一个或多个壁，其中的中空室，多个孔延伸通过 膜的壁并且允许流体进入和离开膜的室，每个孔的尺寸使得其足够大以允许非活性因子VII进入膜的腔室并激活因子VIIa以离开膜的室 膜，但足够小以防止纤维蛋白原进入膜的腔室，多个支撑件设置在腔室内，并且有效量的因子VII活化剂或活化剂源与载体结合，其中非活性因子 通过膜的血液中的VII与活化剂在室内接触时被激活成因子VIIa。本发明a 还提供了一种治疗血友病A或B体外的方法。 本发明还提供了用于治疗AIDS的方法以及用于上述方法的渗透膜。

    Method and apparatus for washing solid media
    7.
    发明授权
    Method and apparatus for washing solid media 失效
    洗涤固体介质的方法和设备

    公开(公告)号：US5112957A

    公开(公告)日：1992-05-12

    申请号：US810503

    申请日：1985-12-19

    申请人： Harvey B. Pollard

    发明人： Harvey B. Pollard

    IPC分类号： C12M1/24

    CPC分类号： C12M23/08 ,  B01L3/10 ,  B01L2200/082 ,  B01L2300/069

    摘要： A method is described for safely and effectively washing solid gels or films containing biological macromolecules such as proteins or nucleic acids. The method involves placing the gels in an open plastic container and decanting a wash solution horizontally so as to leave the gel at the bottom of the container without using external means to hold the gel down. The undamaged gel can then be safely removed and detection experiments can thus be carried out. A preferred apparatus for carrying out this method is also described and consists of an elongated open-topped side spouted tray.

    摘要翻译： 描述了一种安全有效地洗涤含有生物大分子如蛋白质或核酸的固体凝胶或薄膜的方法。 该方法包括将凝胶放置在开放的塑料容器中并水平倾析洗涤溶液，以便将凝胶留在容器的底部，而不用外部手段将凝胶保持在下方。 然后可以安全地除去未损坏的凝胶，因此可以进行检测实验。 还描述了用于执行该方法的优选装置，并且由细长的开口顶部喷射托盘组成。

    Knockout mouse for the tumor suppressor gene ANX7
    9.
    发明授权
    Knockout mouse for the tumor suppressor gene ANX7 失效
    敲除小鼠肿瘤抑制基因ANX7

    公开(公告)号：US07504223B2

    公开(公告)日：2009-03-17

    申请号：US11017756

    申请日：2004-12-22

    申请人： Meera Srivastava ,  Harvey B. Pollard

    发明人： Meera Srivastava ,  Harvey B. Pollard

    IPC分类号： G01N33/53

    CPC分类号： A01K67/0276 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K48/00 ,  C07K14/4721 ,  C12N15/8509 ,  C12N2799/022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/57415 ,  G01N33/57434

    摘要： This invention provides methods, including a method of assessing the prognosis of a breast cancer patient, comprising assaying for loss of heterozygosity at the 10q21 region of the genome of the patient, a method of identifying a probability that a patient with breast cancer has metastasized breast cancer, a method of determining a survival probability of a patient with breast cancer, and a method of identifying a probability that a patient with prostate cancer has a severe form of prostate cancer. This invention also provides assay complexes, including assay complexes which comprise at least one prostate tissue sample or tissue sample extract, an antibody that specifically binds ANX7, and a label, or which comprise at least one breast tissue sample or tissue sample extract, an antibody that specifically binds ANX7, and a label.

    摘要翻译： 本发明提供了包括评估乳腺癌患者的预后的方法的方法，包括测定患者基因组的10q21区域的杂合性丧失的方法，确定乳腺癌患者已转移乳腺的可能性的方法 癌症，确定患有乳腺癌的患者的存活概率的方法，以及鉴定前列腺癌患者具有严重形式的前列腺癌的可能性的方法。 本发明还提供测定复合物，包括测定复合物，其包含至少一种前列腺组织样品或组织样品提取物，特异性结合ANX7的抗体和标记，或包含至少一种乳腺组织样品或组织样品提取物的抗体 特异性结合ANX7和标签。