METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION
    1.
    发明申请
    METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION 有权
    防止麻醉渗透性过渡的方法

    公开(公告)号:US20070027087A1

    公开(公告)日:2007-02-01

    申请号:US11427804

    申请日:2006-06-30

    IPC分类号: A61K38/10 A61K38/08

    摘要: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

    摘要翻译: 本发明提供了减少或预防线粒体渗透性转换的方法。 该方法包括施用有效量的具有至少一个净正电荷的芳族阳离子肽; 至少四个氨基酸; 最多约20个氨基酸; 净正电荷的最小数量(p t)之间的关系,其中2 a是小于或等于p < t + 1,除了当a为1时,p 也可以为1。

    Medicinal Uses of Mu-Opioid Receptor Agonists
    2.
    发明申请
    Medicinal Uses of Mu-Opioid Receptor Agonists 有权
    Mu-Opioid受体激动剂的药物用途

    公开(公告)号:US20070027070A1

    公开(公告)日:2007-02-01

    申请号:US11427606

    申请日:2006-06-29

    IPC分类号: A61K38/12 A61K38/08

    CPC分类号: A61K38/12 A61K38/07 A61K38/08

    摘要: The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two α-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-α-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.

    摘要翻译: 本发明提供了在有需要的哺乳动物中用激动剂肽刺激μ-阿片受体的方法。 所述方法包括向哺乳动物施用有效量的包含至少两个α-氨基酸残基的选择性μ-阿片受体激动剂肽。 至少一个氨基酸残基具有正电荷。 第一位置的氨基酸残基是酪氨酸或酪氨酸衍生物。 第二个位置的氨基酸是D-α-氨基酸。 本发明还提供了通过向哺乳动物施用有效量的肽来治疗患有病症或疾病的哺乳动物的方法。

    POCKET BALL TOY
    3.
    发明申请
    POCKET BALL TOY 审中-公开
    POCKET BALL玩具

    公开(公告)号:US20140349791A1

    公开(公告)日:2014-11-27

    申请号:US14284323

    申请日:2014-05-21

    申请人: Peter Schiller

    发明人: Peter Schiller

    IPC分类号: A63B39/00

    摘要: The present invention relates to a collapsible pocket-sized ball toy and a pocket-sized container or package for the toy, wherein the toy comprises a light weight exterior covering surrounding a light weight expandable spring.

    摘要翻译: 本发明涉及一种可折叠的口袋尺寸的球形玩具和用于玩具的袖珍尺寸的容器或包装,其中该玩具包括围绕重量轻的可膨胀弹簧的重量轻的外部覆盖物。

    Compounds useful in pain management
    4.
    发明授权
    Compounds useful in pain management 有权
    化合物可用于疼痛管理

    公开(公告)号:US06703483B1

    公开(公告)日:2004-03-09

    申请号:US09590165

    申请日:2000-06-09

    申请人: Peter Schiller

    发明人: Peter Schiller

    IPC分类号: C07K510

    摘要: Compounds of the formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, particular in the management of pain, and more particularly in the management of pain during labor.

    摘要翻译: 本申请中公开和要求保护的式I化合物及其药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在治疗疼痛方面的用途,尤其是在劳动中的疼痛管理中 。

    Loom With Detachable Connection Between a Drive Means and the Warp Beam of a Loom
    7.
    发明申请
    Loom With Detachable Connection Between a Drive Means and the Warp Beam of a Loom 审中-公开
    织机与驱动装置与织机经波束之间可拆卸连接的织机

    公开(公告)号:US20080314472A1

    公开(公告)日:2008-12-25

    申请号:US11919621

    申请日:2006-03-29

    IPC分类号: D03D49/60

    CPC分类号: D03D49/06

    摘要: The invention relates to a loom (1) with a warp beam (2) and a drive means (3), in particular, a warp beam gear, whereby the warp beam (2) has a warp beam flange (2.2) and a detachable connection is provided between the warp beam flange (2.2) and the drive means (3), said drive means (3) being mounted in a drive-side frame wall (4) of the loom (1) and the warp beam (2), the warp beam flange (2.2) and the drive means (3) are arranged on a common rotational axis (5). The drive means (3) is connected to the warp beam flange (2.2) by means of screws and the frame wall (4) is provided with recesses such that the screws may be screwed through the recesses and drillings in the drive means (3) into the warp beam flange (2.2).

    摘要翻译: 本发明涉及一种具有经轴(2)和驱动装置(3)的织机(1),特别涉及一种经轴齿轮,由此经轴(2)具有经轴凸缘(2.2)和可拆卸 在经轴法兰(2.2)和驱动装置(3)之间设置有连接,所述驱动装置(3)安装在织机(1)的驱动侧框架壁(4)和经轴(2)中, ,经轴法兰(2.2)和驱动装置(3)布置在共同的旋转轴线(5)上。 驱动装置(3)通过螺钉连接到经轴法兰(2.2),并且框架壁(4)设置有凹槽,使得螺钉可以穿过驱动装置(3)中的凹槽和钻孔, 进入经轴法兰(2.2)。

    Gyroscopic navigation system and method
    8.
    发明申请
    Gyroscopic navigation system and method 审中-公开
    陀螺仪导航系统及方法

    公开(公告)号:US20050192747A1

    公开(公告)日:2005-09-01

    申请号:US11052460

    申请日:2005-02-07

    CPC分类号: G01C19/5719 G01C23/00

    摘要: A compact, lightweight, cost effective, self-contained standby electronic navigation system with high signal-to-noise ratio and good dynamic stability is provided. The system includes a first sensor module for providing a plurality of rotational rate signals, a second sensor module for providing a plurality of compensation signals, and a microcontroller module for processing the rotational rate signals and the compensation signals and sending the signals to a display for displaying attitude information, directional information, and turn coordinate information on a single screen simultaneously. In one embodiment, the first sensor module includes a plurality of rotational sensors made of piezoelectric elements. The piezoelectric elements are made from a single sheet of piezoelectric material so that the elements possess uniform characteristics, and are arranged to reduce systematic drift and random noise normally present in a rotational rate sensor. The sensors can be configured on a single multi-sensor chip.

    摘要翻译: 提供了具有高信噪比和良好的动态稳定性的紧凑,重量轻,成本有效的独立待机电子导航系统。 该系统包括用于提供多个转速信号的第一传感器模块,用于提供多个补偿信号的第二传感器模块,以及用于处理旋转速率信号和补偿信号的微控制器模块,并将信号发送到显示器 在单个屏幕上同时显示姿态信息,方向信息和转动坐标信息。 在一个实施例中,第一传感器模块包括由压电元件制成的多个旋转传感器。 压电元件由单片压电材料制成,使得这些元件具有均匀的特性,并且被布置为减少通常存在于旋转速率传感器中的系统漂移和随机噪声。 传感器可以配置在单个多传感器芯片上。

    Controllable weft thread presenting and clamping apparatus including an
actuated clamp element
    9.
    发明授权
    Controllable weft thread presenting and clamping apparatus including an actuated clamp element 失效
    可控纬纱呈现和夹紧装置包括一个致动的夹紧元件

    公开(公告)号:US6119733A

    公开(公告)日:2000-09-19

    申请号:US441098

    申请日:1999-11-16

    IPC分类号: D03D47/12 D03D47/38 D03D47/34

    CPC分类号: D03D47/125 D03D47/38

    摘要: A weft thread clamp for a weft thread presenting lever is positively actuated to selectively open or close the clamp and thereby release or hold the weft thread respectively. To achieve this, a second clamp element is movable or deflectable relative to a first clamp element of the clamp. The movable second clamp element may be directly embodied as an actuator, or may be driven by an actuating motion provided by an actuator located remotely from the clamp on the lever. In the latter case, a motion transmission arrangement such as a sheathed push-pull cable or a rod linkage operatively connects the actuator to the movable second clamp element. The actuator may be a piezoelectric, electromagnetic, hybrid pneumatic-electric, or hybrid hydraulic-electric device, or an electric motor. The loom control unit is connected to the actuator for providing control signals thereto.

    摘要翻译: 用于纬纱呈现杆的纬纱夹具被积极地致动以选择性地打开或关闭夹具,从而分别释放或保持纬纱。 为了实现这一点,第二夹紧元件相对于夹具的第一夹紧元件是可移动的或可偏转的。 可移动的第二夹紧元件可以被直接体现为致动器,或者可以通过由位于杠杆上的夹具远离的致动器提供的致动运动来驱动。 在后一种情况下,诸如护套推挽电缆或杆连杆的运动传递装置将致动器可操作地连接到可移动的第二夹紧元件。 致动器可以是压电,电磁,混合气动电动或混合式液压电动装置或电动马达。 织机控制单元连接到致动器以向其提供控制信号。

    Weaving loom, particularly an air nozzle weaving loom
    10.
    发明授权
    Weaving loom, particularly an air nozzle weaving loom 失效
    编织机,特别是空气喷嘴编织机

    公开(公告)号:US6050304A

    公开(公告)日:2000-04-18

    申请号:US198447

    申请日:1998-11-24

    IPC分类号: D03D47/30 D03D47/34

    CPC分类号: D03D47/3013

    摘要: An air nozzle weaving loom has a prenozzle alignment arrangement for the weft yarn picking. Several prenozzles (8a) having respective blow pipe (8b) are accommodated in a prenozzle block 9 according to an order system (geometric configuration) corresponding to the order system (geometric configuration) of main nozzles (5a) in the main nozzle block (6).

    摘要翻译: 空气喷嘴编织机具有用于纬纱采摘的预喷嘴对准装置。 根据与主喷嘴块(6)中的主喷嘴(5a)的顺序系统(几何构造)对应的顺序系统(几何构造),将具有各个吹管(8b)的几个预喷嘴(8a)容纳在预喷嘴块9中 )。