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    Biosynthetic human growth hormone
    4.
    发明授权
    Biosynthetic human growth hormone 失效
    生物合成人生长激素

    公开(公告)号：US5633352A

    公开(公告)日：1997-05-27

    申请号：US402286

    申请日：1995-03-10

    申请人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    发明人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    IPC分类号： C07K14/545 ,  C07K14/61 ,  C12N9/22 ,  C12N9/36 ,  C12N15/62 ,  C12P21/06

    CPC分类号： C12N9/2462 ,  C07K14/545 ,  C07K14/61 ,  C12N15/62 ,  C12N9/22 ,  C12P21/06 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/75

    摘要： A desired protein having the formula:A-B-C-Pwhereina) A is Lys or Arg, and B and C are arbitrary amino acids, orb) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro,is produced from a biosynthetically formed amino acid extended protein having the formula:X-A-B-C-Pwherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.

    摘要翻译： 具有下式的所需蛋白质：ABC-P，其中a）A是Lys或Arg，B和C是任意氨基酸，或b）A是不同于Pro，Lys和Arg的任意氨基酸，B和/或C Pro是由具有下式的生物合成形成的氨基酸延伸蛋白产生：XABC-P，其中A，B，C和P如上所定义，X是具有偶数氨基酸的氨基酸序列，其中 第一个，从N末端看，与Lys和Arg不同，所有其他不均匀的氨基酸与Pro，Lys和Arg不同，所有偶联氨基酸与Pro不同，通过与酶二肽基氨基肽酶（ DAP I）。 在纯状态下获得所需的蛋白质。 因此，例如 可以通过该过程产生没有Met-hGH含量的hGH。

    Amino-terminally extended human growth hormone (HGH)
    5.
    发明授权
    Amino-terminally extended human growth hormone (HGH) 失效
    氨基末端延长的人生长激素（HGH）

    公开(公告)号：US5635604A

    公开(公告)日：1997-06-03

    申请号：US450094

    申请日：1995-05-25

    申请人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    发明人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    IPC分类号： C07K14/545 ,  C07K14/61 ,  C12N9/22 ,  C12N9/36 ,  C12N15/62 ,  C12P21/06

    CPC分类号： C12N9/2462 ,  C07K14/545 ,  C07K14/61 ,  C12N15/62 ,  C12N9/22 ,  C12P21/06 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/75

    摘要： A desired protein having the formula:A-B-C-P,wherein (a) A is Lys or Arg, and B and C are arbitrary amino acids, or (b) A is an arbitrary amino acid different from Pro, Lys, and Arg, and B and/or C is Pro is produced from a biosynthetically formed amino-terminally extended protein having the formula:X-A-B-C-P,wherein A, B, C are defined above, and X is an amino acid sequence with an even number of amino acids, of which the first amino acid, seen from the N-terminal end, is different from Lys and Arg, all other am/no acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Specifically, P is human growth hormone (hGH). Thus, compositions of hGH may be produced without the presence of Met-hGH.

    摘要翻译： 具有下式的所需蛋白质：ABCP，其中（a）A是Lys或Arg，B和C是任意氨基酸，或（b）A是不同于Pro，Lys和Arg的任意氨基酸，B和 /或C是Pro由具有下式的生物合成形成的氨基末端延伸蛋白产生：XABCP，其中A，B，C如上定义，X​​是具有偶数氨基酸的氨基酸序列，其中 从N-末端观察到的第一个氨基酸不同于Lys和Arg，所有其他am / no酸都不同于Pro，Lys和Arg，并且所有甚至氨基酸与Pro不同，通过与酶二肽基 氨基肽酶（DAP I）。 在纯状态下获得所需的蛋白质。 具体来说，P是人生长激素（hGH）。 因此，可以在不存在Met-hGH的情况下生产hGH的组合物。

    HYDRAULIC VALVE ARRANGEMENT
    7.
    发明申请
    HYDRAULIC VALVE ARRANGEMENT 有权
    液压阀安装

    公开(公告)号：US20110204267A1

    公开(公告)日：2011-08-25

    申请号：US13098563

    申请日：2011-05-02

    申请人： Thorkild Christensen ,  Siegfried Zenker ,  Svend Erik Thomsen

    发明人： Thorkild Christensen ,  Siegfried Zenker ,  Svend Erik Thomsen

    IPC分类号： F16K31/00

    CPC分类号： F15B11/05 ,  E02F9/2225 ,  E02F9/2267 ,  F15B2211/20538 ,  F15B2211/30555 ,  F15B2211/329 ,  F15B2211/351 ,  F15B2211/50518 ,  F15B2211/50536 ,  F15B2211/55 ,  F15B2211/565 ,  F15B2211/6051 ,  F15B2211/7053 ,  F15B2211/7054

    摘要： The invention concerns a hydraulic valve arrangement (1) with a supply connection arrangement comprising a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement comprising two working connections (A, B), which can be connected to a motor (4), a directional valve arrangement (5) located between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and a compensation valve (15) acted upon in a first activation direction by a pressure in a first pressure chamber (33), which is connected to a load-sensing pipe (LS), and, if required, by a spring (32), and in a second activation direction opposite to the first activation direction by a pressure downstream of the directional valve arrangement (5), said pressure acting in a second pressure chamber (34), the compensation valve (15) having an inlet (14) and an outlet (19). In connection with a post-compensated valve, it is endeavoured to adjust the load pressures at the working connections (A, B) in dependence of the direction. For this purpose, each working connection (A, B) is connected to a control system, which amplifies the effect of the pressure in the first pressure chamber (33) on the compensation valve (15) in dependence of a pressure ruling at the working connection (A, B).

    摘要翻译： 本发明涉及具有包括高压连接（P）和低压连接（T）的供应连接装置的液压阀装置（1），包括两个工作连接（A，B）的工作连接装置，其可以 连接到电动机（4），位于供应连接装置（P，T）和工作连接装置（A，B）之间的方向阀装置（5）和补偿阀（15） 通过连接到负载传感管（LS）的第一压力室（33）中的压力，以及如果需要，通过弹簧（32）和在与第一激活相反的第二激活方向上的压力的激活方向 方向阀装置（5）下游的压力，所述压力作用在第二压力室（34）中，补偿阀（15）具有入口（14）和出口（19）。 结合补偿后阀门，努力根据方向调整工作连接（A，B）的负载压力。 为此，每个工作连接（A，B）连接到控制系统，该控制系统根据工作中的压力判定放大第一压力室（33）中的压力对补偿阀（15）的影响 连接（A，B）。

    Hydraulic valve arrangement
    9.
    发明授权
    Hydraulic valve arrangement 失效
    液压阀装置

    公开(公告)号：US06499505B2

    公开(公告)日：2002-12-31

    申请号：US09952364

    申请日：2001-09-11

    申请人： Siegfried Zenker ,  Thorkild Christensen ,  Carl Christian Dixen ,  Carsten Christensen

    发明人： Siegfried Zenker ,  Thorkild Christensen ,  Carl Christian Dixen ,  Carsten Christensen

    IPC分类号： F15B1304

    CPC分类号： F15B13/01 ,  F15B11/003 ,  F15B2211/3051 ,  F15B2211/30515 ,  F15B2211/30525 ,  F15B2211/3111 ,  F15B2211/3127 ,  F15B2211/3144 ,  F15B2211/31576 ,  F15B2211/327 ,  F15B2211/329 ,  F15B2211/6054 ,  Y10T137/87241

    摘要： A hydraulic valve arrangement includes a control valve (3), which, in a first operating position (5), connects a motor connection (21) with a pump connection, in a second operating position (6), connects a motor connection with a tank connection, and, in a locking position (4), disconnects the motor connection (21) from the pump and tank connection. A locking valve (19) is coupled between the control valve (3) and the motor connection (21), dividing the motor line (22) into a first section (23) allocated to the control valve (3) and a second section (24) allocated to the motor connection (21). For the locking valve (19), a pressure release valve (20) in the shape of a seated valve is provided that is fixed to the housing thereby improving control accuracy.

    摘要翻译： 液压阀装置包括控制阀（3），其在第一操作位置（5）中将马达连接件（21）与泵连接件连接在第二操作位置（6）中，将马达连接件与 油箱连接，并且在锁定位置（4）中，断开马达连接（21）与泵和油箱连接。 锁定阀（19）联接在控制阀（3）和马达连接件（21）之间，将马达管线（22）分成分配给控制阀（3）的第一部分（23）和第二部分 24）分配给电动机连接（21）。 对于锁定阀（19），提供了一种固定在壳体上的带座阀形式的压力释放阀（20），从而提高了控制精度。

    Hydraulic control apparatus for a servomotor
    10.
    发明授权
    Hydraulic control apparatus for a servomotor 失效
    伺服电机液压控制装置

    公开(公告)号：US4548035A

    公开(公告)日：1985-10-22

    申请号：US441105

    申请日：1982-11-12

    申请人： Svend E. Thomsen ,  Thorkild Christensen

    发明人： Svend E. Thomsen ,  Thorkild Christensen

    IPC分类号： F15B9/08 ,  B62D5/09 ,  F15B9/10

    CPC分类号： B62D5/09

    摘要： The invention relates to a steering control unit for a bidirectional servomotor which is connectable to steerable wheels. A steering wheel controlled quantity setting unit of a known type has ports connectable to a pump and a return tank and two control ports through which metered quantities of fluid flow to opposite sides of the servomotor and to other parts of the apparatus for actuating the servomotor. A directional control valve for selectivity directing pressurized fluid from a power circuit to opposite sides of the servomotor is controlled by a control circuit containing the setting unit. A utility valve having pressure regulating and control and power valve capabilities is provided. In cases wherein the quantity setting apparatus is remotely located from the regulating valve the length of the signal channels add to the reaction time. Such reaction time is reduced herein by connecting the metering throttle as a fixed throttle between the regulating valve and quantity setting apparatus so that the regulating valve feeds a substantially constant quantity to the control cicuit, and that the quantity setting apparatus comprises a short circuit path to the tank which closes with an increase in the quantity.

    摘要翻译： 本发明涉及一种用于双向伺服电机的转向控制单元，其可连接到可转向的车轮。 已知类型的方向盘控制量设定单元具有可连接到泵和回流罐的端口和两个控制端口，计量量的流体流过伺服电机的相对侧以及用于致动伺服电动机的装置的其它部分。 用于将加压流体从功率电路选择性地引导到伺服电动机的相对侧的方向控制阀由包含设定单元的控制电路控制。 本发明提供一种具有压力调节和功率阀功能的电力阀。 在数量设定装置远离调节阀的情况下，信号通道的长度增加到反应时间。 这样的反应时间通过将调节阀和量设定装置之间的固定节流阀连接在一起，使得调节阀向控制电路供给基本上恒定的量，并且量设定装置包括短路路径 随着数量的增加关闭的油箱。