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11 条记录 (耗时 0.053 秒)

    Morpholine derivatives
    1.
    发明申请
    Morpholine derivatives 失效
    吗啉衍生物

    公开(公告)号：US20060241302A1

    公开(公告)日：2006-10-26

    申请号：US10561838

    申请日：2004-06-29

    申请人： Hideki Kubota ,  Takanori Yasukouchi ,  Satoru Miyauchi ,  Kayoko Motoki ,  Masanori Saito ,  Hitoshi Iimori

    发明人： Hideki Kubota ,  Takanori Yasukouchi ,  Satoru Miyauchi ,  Kayoko Motoki ,  Masanori Saito ,  Hitoshi Iimori

    IPC分类号： C07D403/02 ,  C07D401/02 ,  C07D213/02

    CPC分类号： C07D213/30 ,  C07C317/14 ,  C07C2601/14

    摘要： Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents —S—, —SO— or —SO2—); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

    摘要翻译： 提供能够抑制β淀粉样蛋白的产生或分泌的化合物。 由下式（1）表示的化合物：其中R 1表示可以具有取代基的杂环基，R 2表示可以具有 可以具有取代基的取代基或杂环基，R 3表示可以具有取代基的环状烃基或可以具有取代基的杂环基，R 4， 表示氢原子或C 1-6烷基，X表示-S - ， - SO-或-SO 2 - ）。 其N-氧化物或S-氧化物; 其盐; 或其溶剂合物; 和含有它们中任何一种的药物。

    Heterocyclic methyl sulfone derivative
    2.
    发明授权
    Heterocyclic methyl sulfone derivative 失效
    杂环甲基砜衍生物

    公开(公告)号：US07932271B2

    公开(公告)日：2011-04-26

    申请号：US10561838

    申请日：2004-06-29

    申请人： Hideki Kubota ,  Takanori Yasukouchi ,  Satoru Miyauchi ,  Kayoko Motoki ,  Masanori Saito ,  Hitoshi Iimori

    发明人： Hideki Kubota ,  Takanori Yasukouchi ,  Satoru Miyauchi ,  Kayoko Motoki ,  Masanori Saito ,  Hitoshi Iimori

    IPC分类号： A61K31/44 ,  C07D401/00 ,  C07D213/72 ,  C07D213/00

    CPC分类号： C07D213/30 ,  C07C317/14 ,  C07C2601/14

    摘要： Provided is a compound capable of inhibiting production or secretion of β amyloid protein.A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents —S—, —SO— or —SO2—); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

    摘要翻译： 本发明提供能够抑制β-葡聚糖的生成或分泌的化合物。 淀粉样蛋白。 由下式（1）表示的化合物：其中，R 1表示可以具有取代基的杂环基，R 2表示可以具有取代基的环状烃基或可以具有取代基的杂环基，R 3表示环状 可以具有取代基的烃基或可以具有取代基的杂环基，R4表示氢原子或C1-6烷基，X表示-S-，-SO-或-SO2-）; 其N-氧化物或S-氧化物; 其盐; 或其溶剂合物; 和含有它们中任何一种的药物。

    ALKYLSULFONE DERIVATIVES
    3.
    发明申请
    ALKYLSULFONE DERIVATIVES 审中-公开
    碱性衍生物

    公开(公告)号：US20100168136A1

    公开(公告)日：2010-07-01

    申请号：US12722282

    申请日：2010-03-11

    申请人： Hitoshi Iimori ,  Hideki Kubota ,  Satoru Miyauchi ,  Kayoko Motoki

    发明人： Hitoshi Iimori ,  Hideki Kubota ,  Satoru Miyauchi ,  Kayoko Motoki

    IPC分类号： C07D213/81 ,  A61K31/519 ,  A61K31/437 ,  A61P25/28 ,  A61P25/00 ,  C07D213/79 ,  C07D487/04 ,  C07D471/04 ,  C07D213/72 ,  C07D213/28 ,  A61K31/443

    CPC分类号： C07D213/48 ,  C07D213/61 ,  C07D213/73 ,  C07D213/74 ,  C07D213/77 ,  C07D213/79 ,  C07D213/81 ,  C07D471/04

    摘要： A compound having activity to inhibit production and/or secretion of β-amyloid protein, and is useful for prevention and/or treatment of various diseases associated with abnormal production and/or secretion of β-amyloid protein, the compound represented by the general formula (I): [wherein, R1 represents a C1-C6 alkyl group which may have 1 to 6 halogen atoms as substituent groups, a C2-C6 alkenyl group which may have 1 to 6 halogen atoms as substituent groups, or a C3-C7 cycloalkyl group which may have 1 to 6 halogen atoms as substituent groups; R2 represents a 6-membered nitrogen-containing monocyclic aromatic heterocyclic group having 1 to 3 substituent groups, or a 9- or 10-membered nitrogen-containing bicyclic heterocyclic group having 1 to 4 substituent groups; Z1, Z2 and Z3 each independently represent a hydrogen atom, a halogen atom or a cyano group; and n represents 0, 1 or 2], salts thereof, or solvates thereof.

    摘要翻译： 具有抑制β-淀粉样蛋白的生成和/或分泌活性的化合物，可用于预防和/或治疗与淀粉样蛋白异常产生和/或分泌相关的各种疾病，所述化合物由 通式（I）：[其中，R 1表示可以具有1〜6个卤素原子作为取代基的C 1〜C 6烷基，可以具有1〜6个卤素原子作为取代基的C 2〜C 6烯基或C 3 可以具有1至6个卤素原子作为取代基的-C 7环烷基; R2表示具有1〜3个取代基的6元含氮单环芳族杂环基或具有1〜4个取代基的9元或10元含氮双环杂环基; Z 1，Z 2和Z 3各自独立地表示氢原子，卤素原子或氰基; 和n表示0,1或2]，其盐或溶剂化物。

    Method for processing magnetic resonance imaging image information and magnetic resonance imaging system
    9.
    发明授权
    Method for processing magnetic resonance imaging image information and magnetic resonance imaging system 失效
    磁共振成像图像信息和磁共振成像系统的处理方法

    公开(公告)号：US06943549B2

    公开(公告)日：2005-09-13

    申请号：US10679343

    申请日：2003-10-07

    申请人： Masahiko Matsuo ,  Hideo Eda ,  Satoru Miyauchi

    发明人： Masahiko Matsuo ,  Hideo Eda ,  Satoru Miyauchi

    IPC分类号： G01R33/32 ,  A61B5/055 ,  G01R33/54 ,  G01R33/56 ,  G06T1/00 ,  G01V3/00 ,  G06K9/36

    CPC分类号： G01R33/56 ,  G01R33/5608

    摘要： A method for processing magnetic resonance imaging image information is characterized by that a magnetic resonance spectral intensity value is measured at each of a plurality of measuring points that are arranged at predetermined intervals along a lengthwise direction, a crosswise direction and a height direction on an object to be measured and several kinds of magnetic resonance imaging image information as a set of the magnetic resonance spectral intensity values measured at the measuring point are obtained by a plurality of different spectral intensity measuring methods with respect to the object to be measured, a magnetic resonance spectral intensity value at the predetermined position is obtained directly or indirectly from a measured results of the magnetic resonance spectral intensity values that is included in the magnetic resonance imaging image information and the predetermined position is set to be identical for all of the several varieties of magnetic resonance imaging image information with respect to each of the magnetic resonance imaging image information, and new image information at the predetermined position is derived by linear calculation between the spectral intensity values.

    摘要翻译： 一种用于处理磁共振成像图像信息的方法的特征在于，在沿着物体上的长度方向，横向和高度方向以预定间隔布置的多个测量点中的每一个测量点处测量磁共振光谱强度值 通过针对被测量物体的多种不同的光谱强度测定方法得到测定点上测定的磁共振光谱强度值的集合的多种磁共振成像图像信息，磁共振 从包含在磁共振成像图像信息中的磁共振光谱强度值的测量结果直接或间接获得预定位置处的光谱强度值，并且将预定位置设置为对于所有几种磁性 共振成像图像 关于每个磁共振成像图像信息的e信息和在预定位置处的新图像信息通过光谱强度值之间的线性计算导出。