公开(公告)号：US07262212B2

公开(公告)日：2007-08-28

申请号：US10530429

申请日：2003-10-10

申请人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Hideaki Kuroda ,  Motohiro Itotani ,  Takeshi Hasegawa ,  Yoshikazu Haraguchi ,  Takeshi Kuroda ,  Takayuki Matsuzaki ,  Kuninori Tai ,  Makoto Komatsu ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Yuji Seike ,  Masanori Kawasaki ,  Takumi Sumida ,  Shin Miyamura

发明人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Hideaki Kuroda ,  Motohiro Itotani ,  Takeshi Hasegawa ,  Yoshikazu Haraguchi ,  Takeshi Kuroda ,  Takayuki Matsuzaki ,  Kuninori Tai ,  Makoto Komatsu ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Yuji Seike ,  Masanori Kawasaki ,  Takumi Sumida ,  Shin Miyamura

IPC分类号： A61K31/424 ,  A61K31/438 ,  C07D498/04 ,  C07D401/14

CPC分类号： C07D498/04 ,  C07D498/20 ,  C07F7/0812

摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group —OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and —(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

摘要翻译： 本发明提供由下列通式表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物：其中R 1表示氢原子或C 1 -C 6烷基 ，n表示0〜6的整数，R 2表示基团-OR 3等，R 3表示氢原子 ，C 1 -C 6烷基等，或R 1和 - （CH 2）n R 2 R 2， 可以通过氮原子与与其相邻的碳原子彼此结合形成由通式（H）表示的螺环：其中R 41是氢，C 1 -C 6烷基或 喜欢。 本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

公开(公告)号：US20080119478A1

公开(公告)日：2008-05-22

申请号：US10574597

申请日：2004-10-29

申请人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Motohiro Itotani ,  Yoshikazu Haraguchi ,  Shin Miyamura ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Kinue Ohguro ,  Takumi Sumida ,  Takeshi Hasegawa ,  Kazuho Tanaka ,  Isao Takemura

发明人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Motohiro Itotani ,  Yoshikazu Haraguchi ,  Shin Miyamura ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Kinue Ohguro ,  Takumi Sumida ,  Takeshi Hasegawa ,  Kazuho Tanaka ,  Isao Takemura

IPC分类号： A61K31/497 ,  A61K31/41 ,  A61K31/445 ,  C07D211/68 ,  C07D413/00 ,  C07D498/02 ,  C07D215/00 ,  A61P31/00 ,  A61K31/47

CPC分类号： C07D498/04

摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

摘要翻译： 本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R 1和 - （CH 2）n R 2可以与下述式（30）表示的螺环连同相邻的碳原子（在 式中，RRR表示哌啶环上可具有取代基的哌啶基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。 本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

公开(公告)号：US08163753B2

公开(公告)日：2012-04-24

申请号：US10574597

申请日：2004-10-29

申请人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Motohiro Itotani ,  Yoshikazu Haraguchi ,  Shin Miyamura ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Kinue Ohguro ,  Takumi Sumida ,  Takeshi Hasegawa ,  Kazuho Tanaka ,  Isao Takemura

发明人： Hidetsugu Tsubouchi ,  Hirofumi Sasaki ,  Motohiro Itotani ,  Yoshikazu Haraguchi ,  Shin Miyamura ,  Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Kinue Ohguro ,  Takumi Sumida ,  Takeshi Hasegawa ,  Kazuho Tanaka ,  Isao Takemura

IPC分类号： A61K31/497 ,  A61K31/47 ,  A61K31/445 ,  A61K31/42 ,  C07D419/06 ,  C07D215/04 ,  C07D213/72 ,  C07D498/04

CPC分类号： C07D498/04

摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

摘要翻译： 本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R1和 - （CH2）nR2可以与相邻的碳原子一起形成由下式（30）表示的螺环（在下式中，RRR表示哌啶基 其可以在哌啶环上具有取代基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。 本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

公开(公告)号：US09051333B2

公开(公告)日：2015-06-09

申请号：US14111262

申请日：2012-04-13

申请人： Yoshikazu Kawano ,  Yoshikazu Haraguchi ,  Hirofumi Sasaki ,  Yukitaka Uematsu ,  Hidetsugu Tsubouchi ,  Hiromi Yata ,  Hiroshi Shimizu ,  Kazuho Kohashi ,  Motohiro Itotani ,  Kuninori Tai ,  Isao Takemura ,  Mikayo Hayashi ,  Hiroyuki Hashizume ,  Miki Matsuba ,  Izuru Nakamura ,  Xiuhao Chen ,  Makoto Matsumoto

发明人： Yoshikazu Kawano ,  Yoshikazu Haraguchi ,  Hirofumi Sasaki ,  Yukitaka Uematsu ,  Hidetsugu Tsubouchi ,  Hiromi Yata ,  Hiroshi Shimizu ,  Kazuho Kohashi ,  Motohiro Itotani ,  Kuninori Tai ,  Isao Takemura ,  Mikayo Hayashi ,  Hiroyuki Hashizume ,  Miki Matsuba ,  Izuru Nakamura ,  Xiuhao Chen ,  Makoto Matsumoto

IPC分类号： C07D498/04 ,  A61K31/5383

CPC分类号： C07D498/04

摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.

摘要翻译： 本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。 具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。 任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基 ，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。 本发明还提供含有上述物质的药物组合物。

公开(公告)号：US20140031342A1

公开(公告)日：2014-01-30

申请号：US14111262

申请日：2012-04-13

申请人： Yoshikazu Kawano ,  Yoshikazu Haraguchi ,  Hirofumi Sasaki ,  Yukitaka Uematsu ,  Hidetsugu Tsubouchi ,  Hiromi Yata ,  Hiroshi Shimizu ,  Kazuho Kohashi ,  Motohiro Itotani ,  Kuninori Tai ,  Isao Takemura ,  Mikayo Hayashi ,  Hiroyuki Hashizume ,  Miki Matsuba ,  Izuru Nakamura ,  Xiuhao Chen ,  Makoto Matsumoto

发明人： Yoshikazu Kawano ,  Yoshikazu Haraguchi ,  Hirofumi Sasaki ,  Yukitaka Uematsu ,  Hidetsugu Tsubouchi ,  Hiromi Yata ,  Hiroshi Shimizu ,  Kazuho Kohashi ,  Motohiro Itotani ,  Kuninori Tai ,  Isao Takemura ,  Mikayo Hayashi ,  Hiroyuki Hashizume ,  Miki Matsuba ,  Izuru Nakamura ,  Xiuhao Chen ,  Makoto Matsumoto

IPC分类号： C07D498/04

CPC分类号： C07D498/04

摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.

摘要翻译： 本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异的杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。 具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。 任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基 ，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。 本发明还提供含有上述物质的药物组合物。

公开(公告)号：US20090275528A1

公开(公告)日：2009-11-05

申请号：US12088867

申请日：2006-10-04

申请人： Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Yoshihiko Shimokawa

发明人： Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Yoshihiko Shimokawa

IPC分类号： A61K31/7042 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/7008 ,  A61K31/4965

CPC分类号： A61K31/4965 ,  A61K31/133 ,  A61K31/424 ,  A61K31/427 ,  A61K31/451 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/52 ,  A61K31/536 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.

摘要翻译： 本发明提供具有较高效力的抗结核药物。 本发明还提供含有（I）通式（1）表示的恶唑化合物的抗结核药物：其中，R1表示氢原子或C1-6烷基，n表示0-6的整数，R2表示通式 （A）等，其中R 3表示苯氧基（选自卤素原子，任选卤素取代的C 1-6烷基和任选卤素取代的C 1-6烷氧基的至少一个基团可以 在苯环上取代）等]，其光学活性形式或其盐，以及药物（II）如初级抗结核药物。

公开(公告)号：US08987304B2

公开(公告)日：2015-03-24

申请号：US12088867

申请日：2006-10-04

申请人： Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Yoshihiko Shimokawa

发明人： Makoto Matsumoto ,  Hiroyuki Hashizume ,  Tatsuo Tomishige ,  Masanori Kawasaki ,  Yoshihiko Shimokawa

IPC分类号： A61K31/454 ,  A61K31/496 ,  A61K31/4409 ,  A61K31/133 ,  A61K31/70 ,  A61K31/50 ,  A61K31/451 ,  A61K31/424 ,  A61K45/06

CPC分类号： A61K31/4965 ,  A61K31/133 ,  A61K31/424 ,  A61K31/427 ,  A61K31/451 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/52 ,  A61K31/536 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.

摘要翻译： 本发明提供具有较高效力的抗结核药物。 本发明还提供含有（I）通式（1）表示的恶唑化合物的抗结核药物：其中，R1表示氢原子或C1-6烷基，n表示0-6的整数，R2表示通式 （A）等，其中R 3表示苯氧基（选自卤素原子，任选卤素取代的C 1-6烷基和任选卤素取代的C 1-6烷氧基的至少一个基团可以 在苯环上取代）等]，其光学活性形式或其盐，以及药物（II）如初级抗结核药物。

公开(公告)号：US09023365B2

公开(公告)日：2015-05-05

申请号：US12278916

申请日：2007-02-08

申请人： Shigeto Yoshida ,  Yoshio Ohba ,  Norimitsu Hariguchi ,  Masami Mizukoshi ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshihiro Goto

发明人： Shigeto Yoshida ,  Yoshio Ohba ,  Norimitsu Hariguchi ,  Masami Mizukoshi ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshihiro Goto

IPC分类号： C12N15/62 ,  C12N15/866 ,  A61K39/015 ,  C12N15/86 ,  A61K39/04 ,  A61K39/145 ,  C07K14/005 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/00 ,  A61K39/015 ,  A61K39/04 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/543 ,  A61K2039/544 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/43 ,  C12N2710/14143 ,  C12N2760/16134 ,  C12N2830/205 ,  Y02A50/386 ,  Y02A50/394 ,  Y02A50/41 ,  Y02A50/412

摘要： A recombinant transfer vector capable of expressing a foreign gene fused to a viral gene under the control of dual promoters and a recombinant baculovirus, and methods for production thereof, as well as pharmaceuticals comprising the recombinant baculovirus as an active ingredient.

摘要翻译： 能够在双重启动子和重组杆状病毒的控制下表达与病毒基因融合的外源基因的重组转移载体及其制备方法，以及包含重组杆状病毒作为活性成分的药物。

公开(公告)号：US09333249B2

公开(公告)日：2016-05-10

申请号：US12192927

申请日：2008-08-15

申请人： Shigeto Yoshida ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshio Ohba ,  Masahiro Saito ,  Yoshihiro Goto ,  Katsuya Inagaki ,  Masami Mizukoshi ,  Norimitsu Hariguchi ,  Kuniko Hirota

发明人： Shigeto Yoshida ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshio Ohba ,  Masahiro Saito ,  Yoshihiro Goto ,  Katsuya Inagaki ,  Masami Mizukoshi ,  Norimitsu Hariguchi ,  Kuniko Hirota

IPC分类号： A61K39/145 ,  C12N15/00 ,  A61K35/76 ,  A61K9/127 ,  A61K39/015 ,  A61K39/04 ,  C07K14/005 ,  A61K39/12 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/04 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/543 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2710/14143 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/394 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.

公开(公告)号：US09327018B2

公开(公告)日：2016-05-03

申请号：US13617825

申请日：2012-09-14

申请人： Shigeto Yoshida ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshio Ohba ,  Masahiro Saito ,  Yoshihiro Goto ,  Katsuya Inagaki ,  Masami Mizukoshi ,  Norimitsu Hariguchi ,  Kuniko Hirota

发明人： Shigeto Yoshida ,  Masanori Kawasaki ,  Makoto Matsumoto ,  Yoshio Ohba ,  Masahiro Saito ,  Yoshihiro Goto ,  Katsuya Inagaki ,  Masami Mizukoshi ,  Norimitsu Hariguchi ,  Kuniko Hirota

IPC分类号： A61K39/12 ,  A61P33/06 ,  C12N7/01 ,  A61K39/015 ,  A61K39/04 ,  A61K39/145 ,  C07K14/005 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/04 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/543 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2710/14143 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/394 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.

摘要翻译： 本发明提供新型转移载体和重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物，其可用作传染病如疟疾和流感的预防或治疗药物; 以及预防和治疗疟疾和流感等传染病的方法。 更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物; 以及用于预防和治疗诸如疟疾和流感的传染病的方法，包括向患者施用重组杆状病毒。