摘要:
Platelet Activating Factor (PAF) antagonists which comprise the compounds of the formula (I): ##STR1## wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R.sup.1, R.sup.2 and R.sup.3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal.Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4-yl group are novel compounds and exhibit excellent PAF antagonism.
摘要:
Novel 1,4-disubstituted piperazine compounds represented by the formula (I): ##STR1## wherein A is a condensed polycyclic hydrocarbon group;R is a phenyl group substituted with a lower alkoxy group;X is methylene group, carbonyl group or thiocarbonyl group;and m is 2 or 3, and their saltsare useful as a platelet activating factor antagonist.
摘要:
The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group represented by the formula: OR1 (wherein R1 represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents) or a group represented by the formula: wherein R1b represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R1c is, same with or different from R1b, a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R0 represents a hydrogen atom or an aliphatic hydrocarbon group, or R and R0 represents a bond with each other, Ar represents an aromatic hydrocarbon group optionally having substituents, and n is an integer of 1 to 4, or a salt thereof, which is a agent for preventing or treating diseases such as cardiac disease, autoimmune disease, septick shock, etc.
摘要:
The novel 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivertives of the formula (I): ##STR1## wherein, R.sup.0, R.sup.1 and R.sup.2 are the same or different and represent a hydrogen atom or a lower alkyl group; A represents a formula: ##STR2## wherein, X stands for a chemical bond or a formula: ##STR3## (wherein, X' stands for a chemical bond or an alkylene group having 1 to 5 carbon atoms which may contain sulfur or oxygen atom as the constituent atoms, R.sup.5 and R.sup.6 are the same or different and stand for a hydrogen atom or a lower alkyl group), R.sup.3 stands for an aromatic heterocyclic group which may be substituted, n denotes 0, 1 or 2), and R.sup.4 stands for a hydrogen atom or an alkanoyl group, or a physiologically acceptable salt thereof have antifungal activities, and they are used for preventing or treating infectious diseases caused by fungi.
摘要翻译:式(I)的新型2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丙醇衍生物:其中R 0 R 1和R 2相同或不同,表示氢原子或低级烷基; A表示下式:其中,X表示化学键或式:其中X表示化学键或可含有硫或氧原子的具有1至5个碳原子的亚烷基 作为构成原子,R5和R6相同或不同,代表氢原子或低级烷基),R3代表可被取代的芳族杂环基,n表示0,1或2),R4表示 对于氢原子或烷酰基或其生理上可接受的盐具有抗真菌活性,并且它们用于预防或治疗由真菌引起的感染性疾病。
摘要:
A compound having the formula (I) or (II) ##STR1## wherein R.sup.1 is a hydrogen atom or an organic residue bonded via a carbon atom, R.sup.2 is a hydrogen atom or a N-protecting group, --COR.sup.3 is an optionally esterified or amidated carboxyl group, R.sup.4 and R.sup.5 are the same or different and respectively a hydrogen atom or an acyl group or a chain or alicyclic hydrocarbon group optionally having an aryl substituent, R.sup.6 is NOH or O, n is an integer of 0 to 3, or R.sup.4 and R.sup.5 together with the adjacent nitrogen atom may form a ring or an optionally substituted benzylidene amino group, which is useful therapeutics of brain dysfunction.
摘要:
A voltage control system for vehicles includes a power supply control circuit which allows power to be supplied to a voltage regulator circuit from a battery through a voltage detection line only when a key switch is turned on. The voltage regulator circuit controls the energization of a generator depending on the terminal voltage of the battery detected through the voltage detection line. The power supply control circuit includes a voltage divider circuit for detecting a voltage developed at an output terminal of an auxiliary rectifier associated with the generator when the connection of the output terminal to the battery is completed upon closing the key switch. The power supply control circuit also includes an output transistor controlled by the voltage detected by the voltage divider circuit and when the detected voltage reaches a predetermined level, the output transistor is rendered conductive and allows the supply of power from the battery to the voltage regulator circuit through the voltage detection line.
摘要:
A generator operation indicating apparatus for vehicle generators having a protective circuit against abnormal voltage, includes a drive circuit for turning an indicating device on from the time of closing of a key switch until the time that a vehicle generator attains a predetermined operating condition to indicate the generator operation and a control circuit for forcibly rendering the drive circuit inoperative in response to the occurrence of an abnormal voltage between the indicating device and the drive circuit. When the generator attains the predetermined operating condition, the indicating device is turned off and the supply of current to a load circuit is started. In this case, the drive circuit is also forced to come out of operation upon occurrance of an abnormal supply voltage.
摘要:
A semi-conductor voltage regulation system for a vehicle includes engine rise-up detection circuit and an oscillator circuit. The field exciting current is intermittently supplied by the oscillator circuit before the engine starts and continuously supplied after the engine has started so as to minimize battery discharge. The engine rise-up detection circuit changes its input impedance in accordance with the voltage applied thereto, whereby a highly reliable regulator with less heat generation may be obtained.
摘要:
The plasma display panel includes a pair of glass substrates forming therein display cells. One substrate has address electrodes and the other has sustain electrodes including X-electrodes and Y-electrodes. X-electrodes are connected to terminals of sustain pulse generating circuits provided on a printed circuit board, via intermediate circuit boards. The printed circuit board and the intermediate circuit boards are connected to each other by connectors having a first set of terminals connected to the first sustain pulse generating circuit and a second set of terminals connected to the second sustain pulse generating circuit. Terminals of first and second sets are arranged in a row alternately one by one, or group by group.
摘要:
The present invention provides an azole compound represented by the formula (I): ##STR1## wherein Ar is an optionally substituted phenyl group; R.sup.1 and R.sup.2, the same or different, are a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 may combine together to form a lower alkylene group; R.sup.3 is a hydrogen atom or an acyl group; X is a nitrogen atom or a methine group; A is Y.dbd.Z (Y and Z, the same or different, are a nitrogen atom or a methine group optionally substituted with a lower alkyl group) or an ethylene group optionally substituted with a lower alkyl group; n is an integer from 0 to 2; and Az is an optionally substituted azolyl group, or its salt, which is useful for a prevention and therapy of a fungal infection of a mammal as a antifungal agent.