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    1 2 4-triazole compound
    1.
    发明授权
    1 2 4-triazole compound 有权
    1 2 4-三唑化合物

    公开(公告)号：US07074816B2

    公开(公告)日：2006-07-11

    申请号：US10495322

    申请日：2002-12-03

    申请人： Hiroshi Nakamura ,  Soichi Kaneda ,  Takahiro Sato ,  Naoki Ashizawa ,  Koji Matsumoto ,  Takashi Iwanaga ,  Tsutomu Inoue

    发明人： Hiroshi Nakamura ,  Soichi Kaneda ,  Takahiro Sato ,  Naoki Ashizawa ,  Koji Matsumoto ,  Takashi Iwanaga ,  Tsutomu Inoue

    IPC分类号： C07D249/08 ,  A61K31/41

    CPC分类号： C07D413/10 ,  C07D311/16 ,  C07D401/04 ,  C07D401/14

    摘要： A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1): wherein R2 represents an unsubstituted or substituted pyridyl group, R1 represents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and R3 represents hydrogen or a lower alkyl group substituted with pivaloyloxy group and R3 bonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.

    摘要翻译： 提供了一种新颖的1,2,4-三唑化合物，其可用作高尿酸血症和由于高尿酸血症引起的痛风的治疗剂。 化合物由以下通式（1）表示：其中R 2代表未取代或取代的吡啶基，R 1代表类似的吡啶基，吡啶-N 对应于这些吡啶基的苯氧基或苯基，R 3表示氢或被三氟甲酰氧基取代的低级烷基和R 3键连接到氮原子上 在环中。 还提供了通过腈和酰肼反应生产化合物的方法，以及治疗剂，特别是黄嘌呤氧化酶抑制剂。

    NOVEL PHENOL DERIVATIVE
    3.
    发明申请
    NOVEL PHENOL DERIVATIVE 有权
    新颖的酚醛衍生物

    公开(公告)号：US20120184587A1

    公开(公告)日：2012-07-19

    申请号：US13499190

    申请日：2010-09-29

    申请人： Seiichi Kobashi ,  Junichiro Uda ,  Sachiho Miyata ,  Tsutomu Inoue ,  Naoki Ashizawa ,  Koji Matsumoto ,  Tetsuya Taniguchi ,  Takashi Iwanaga ,  Osamu Nagata

    发明人： Seiichi Kobashi ,  Junichiro Uda ,  Sachiho Miyata ,  Tsutomu Inoue ,  Naoki Ashizawa ,  Koji Matsumoto ,  Tetsuya Taniguchi ,  Takashi Iwanaga ,  Osamu Nagata

    IPC分类号： A61K31/428 ,  C07D417/10 ,  A61P7/00 ,  A61P3/04 ,  A61P19/06 ,  A61P3/10 ,  A61P9/12 ,  A61P9/10 ,  A61P7/02 ,  C07D277/62 ,  A61P3/06

    CPC分类号： C07D277/62 ,  C07D417/02 ,  C07D417/10

    摘要： Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(═O)— group or an —S(═O)2— group.)

    摘要翻译： 公开了一种新型化合物和药物，其具有显着的尿酸营养作用。 具体公开的是：图1所示的通式（1）表示的新型苯酚衍生物。 1; 其药学上可接受的盐; 衍生物或盐的水合物; 和衍生物或盐的溶剂化物。 （式中，R 1，R 2可以相同或不同，表示低级烷基，低级烯基，低级炔基，低级烷氧基，卤代烷基，卤代烷氧基，烷基硫烷基， 烷基亚磺酰基，烷基磺酰基，低级烷基取代氨基甲酰基，饱和含氮杂环N-羰基，卤素原子，氰基或氢原子; R3表示低级烷基，卤代烷基， 卤素原子，羟基或氢原子; X表示硫原子，-S（= O） - 基或-S（= O）2 - 基）。

    Phenol derivative
    4.
    发明授权
    Phenol derivative 有权
    苯酚衍生物

    公开(公告)号：US08367843B2

    公开(公告)日：2013-02-05

    申请号：US13499190

    申请日：2010-09-29

    申请人： Seiichi Kobashi ,  Junichiro Uda ,  Sachiho Miyata ,  Tsutomu Inoue ,  Naoki Ashizawa ,  Koji Matsumoto ,  Tetsuya Taniguchi ,  Takashi Iwanaga ,  Osamu Nagata

    发明人： Seiichi Kobashi ,  Junichiro Uda ,  Sachiho Miyata ,  Tsutomu Inoue ,  Naoki Ashizawa ,  Koji Matsumoto ,  Tetsuya Taniguchi ,  Takashi Iwanaga ,  Osamu Nagata

    IPC分类号： A61K31/428 ,  C07D277/62

    CPC分类号： C07D277/62 ,  C07D417/02 ,  C07D417/10

    摘要： Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, R1 and R2 may be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; R3 represents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an —S(═O)— group or an —S(═O)2— group.)

    摘要翻译： 公开了一种新型化合物和药物，其具有显着的尿酸营养作用。 具体公开的是：图1所示的通式（1）表示的新型苯酚衍生物。 1; 其药学上可接受的盐; 衍生物或盐的水合物; 和衍生物或盐的溶剂化物。 （式中，R 1，R 2可以相同或不同，表示低级烷基，低级烯基，低级炔基，低级烷氧基，卤代烷基，卤代烷氧基，烷基硫烷基， 烷基亚磺酰基，烷基磺酰基，低级烷基取代氨基甲酰基，饱和含氮杂环N-羰基，卤素原子，氰基或氢原子; R3表示低级烷基，卤代烷基， 卤素原子，羟基或氢原子; X表示硫原子，-S（= O） - 基或-S（= O）2 - 基）。

    Fuel injection device for diesel engines
    5.
    发明授权
    Fuel injection device for diesel engines 失效
    柴油发动机燃油喷射装置

    公开(公告)号：US5156132A

    公开(公告)日：1992-10-20

    申请号：US508712

    申请日：1990-04-16

    申请人： Takashi Iwanaga

    发明人： Takashi Iwanaga

    IPC分类号： F02B3/06 ,  F02M45/08 ,  F02M47/02

    CPC分类号： F02M45/08 ,  F02M47/027 ,  F02B3/06

    摘要： A Diesel fuel injection device has a pressure accumulation piping for accumualting a fuel at a high pressure and an injector for injecting the fuel supplied by the pressure accumulating piping. The injector including a nozzle needle operative to open and close an injection orifice and a three-way solenoid valve operative to control the fuel pressure acting on the nozzle needle. The three-way solenoid valve is controlled to actuate the nozzle needle and to cause the fuel in the pressure accumulation piping to be injected through the injection orifice. A control valve is provided to control the injection rate characteristic to provide a boot-type injection characteristic. A boot type invention characteristic that is defined by a first characteristic in which the injection rate is substantially constant for a predetermined time period, a subsequent second characteristic in which the injection rate is gradually increased from the first characteristic, and a subsequent third characteristic in which the injection rate is suddenly decreased from the second characteristic; whereby operation noise is be reduced.

    Mount for an earth magnetism sensor for use in an automotive vehicle
    6.
    发明授权
    Mount for an earth magnetism sensor for use in an automotive vehicle 失效
    安装用于汽车用的地磁传感器

    公开(公告)号：US4535547A

    公开(公告)日：1985-08-20

    申请号：US345415

    申请日：1982-02-03

    申请人： Norimitsu Kurihara ,  Toshiyasu Suzuki ,  Takashi Iwanaga ,  Masaru Hisadomi

    发明人： Norimitsu Kurihara ,  Toshiyasu Suzuki ,  Takashi Iwanaga ,  Masaru Hisadomi

    IPC分类号： G01C17/18 ,  G01C17/38

    CPC分类号： G01C17/18

    摘要： A mount for an earth magnetism sensor device for use in a bearing detecting apparatus which is to be provided on an automotive vehicle adapted to detect a horizontal component of the earth magnetism, characterized in that an axis of detecting a primary direction of the earth magnetism sensor means is offset in the horizontal direction in coincidence with an extent of magnetic declination at a given spot of observation with respect to a desired orientation by way of a map.

    摘要翻译： 一种用于用于轴承检测装置的地面磁传感器装置的安装件，其将设置在适于检测地磁的水平分量的机动车辆上，其特征在于，检测地磁传感器的主方向的轴 装置在水平方向上偏移，与通过地图相对于期望的取向在给定的观察点处的磁倾角的程度一致。

    Fuel injection system
    7.
    发明授权
    Fuel injection system 失效
    燃油喷射系统

    公开(公告)号：US4777921A

    公开(公告)日：1988-10-18

    申请号：US44859

    申请日：1987-05-01

    申请人： Masahiko Miyaki ,  Takashi Iwanaga ,  Hideya Fujisawa

    发明人： Masahiko Miyaki ,  Takashi Iwanaga ,  Hideya Fujisawa

    IPC分类号： F02M51/00 ,  F02B3/06 ,  F02D41/30 ,  F02D41/38 ,  F02M55/02 ,  F02M59/36 ,  F02M59/46 ,  F02M59/48 ,  F02M63/00 ,  F02M63/02 ,  F02M39/00

    CPC分类号： F02M63/0225 ,  F02D41/3827 ,  F02D41/3845 ,  F02M59/366 ,  F02M59/466 ,  F02M59/48 ,  F02M63/0007 ,  F02B3/06 ,  F02D2200/0602 ,  F02D2250/31 ,  F02M2200/40

    摘要： A fuel injection system for a diesel engine has fuel pump driven by the engine for producing highly pressurized fuel, a common rail for storing the pressurized fuel therein and injection nozzles for injecting the pressurized fuel stored in the common rail into the engine. The injection nozzles are electrically controlled in accordance with engine operating conditions (N, .alpha.) by the use of injection control solenoid valves provided between the injection nozzles and the common rail. The fuel pump is electrically controlled in accordance with the engine operating conditions by the use of a spill control solenoid valve which spills the pressurized fuel to a low pressure fuel channel so that loss of engine torque required by the pump is reduced.

    摘要翻译： 用于柴油发动机的燃料喷射系统具有由用于产生高压燃料的发动机驱动的燃料泵，用于储存加压燃料的共轨和用于将存储在共轨中的加压燃料喷射到发动机中的喷嘴。 注射喷嘴根据发动机工作条件（N，α）通过使用设置在喷射喷嘴和共轨之间的喷射控制电磁阀来电控制。 燃料泵根据发动机的运行条件通过使用溢流控制电磁阀进行电控制，该溢流控制电磁阀将加压燃料溢出到低压燃料通道，从而减少泵所需的发动机转矩的损失。

    Valve
    8.
    发明授权
    Valve 失效
    阀

    公开(公告)号：US5125575A

    公开(公告)日：1992-06-30

    申请号：US762268

    申请日：1991-09-20

    申请人： Takashi Iwanaga

    发明人： Takashi Iwanaga

    IPC分类号： F02M51/06 ,  F02M47/00 ,  F02M47/02

    CPC分类号： F02M47/027

    摘要： A valve having a first valve body including a first contacting surface, a pressurized fluid supply path opening to the first contacting surface and a pressure-controlled chamber opening to the first contacting surface. A second valve body includes a second contacting surface contacting with the first contacting surface and a valve path whose ends open to the second contact surface, and which connects fluidly the pressurized fluid supply path to the pressure-controlled chamber. A valve is arranged in the second valve body and moved to a closed or open position at which the valve means does or does not cut off the fluidal connection between the pressurized fluid supply path and the pressure-controlled chamber. An actuator arranged on the second valve body moves the valve to the closed or opened position. A first drawing means presses the first contacting surface and the second contacting surface against each other. A second drawing means sets the actuator on the second valve body. The force of the first drawing means is not applied to the actuator and therefore the operation of the actuator is not disturbed by the force pressing the first contacting surface and the second contacting surface against each other. Also, the actuator can be removed from the valve without dissembling the first and second valve bodies.

    摘要翻译： 一种具有第一阀体的阀，包括第一接触表面，通向第一接触表面的加压流体供应通道和通向第一接触表面的压力控制室。 第二阀体包括与第一接触表面接触的第二接触表面和其端部朝向第二接触表面开口并且将加压流体供应路径流体地连接到压力控制室的阀路径。 阀被布置在第二阀体中并且移动到闭合或打开位置，在该位置阀装置确实或不切断加压流体供应路径和压力控制室之间的流体连接。 布置在第二阀体上的致动器将阀移动到关闭或打开位置。 第一拉丝装置将第一接触表面和第二接触表面相互压迫。 第二拉伸装置将致动器设置在第二阀体上。 第一拉伸装置的力不施加到致动器，因此致动器的操作不会受到第一接触表面和第二接触表面相互压迫的力的干扰。 此外，致动器可以从阀门移除，而不会拆卸第一和第二阀体。

    Accumulator fuel injection apparatus
    10.
    发明授权
    Accumulator fuel injection apparatus 失效
    蓄能器燃油喷射装置

    公开(公告)号：US5472142A

    公开(公告)日：1995-12-05

    申请号：US323226

    申请日：1994-10-14

    申请人： Takashi Iwanaga

    发明人： Takashi Iwanaga

    IPC分类号： F02B3/06 ,  F02M45/08 ,  F02M47/02 ,  F02M45/02

    CPC分类号： F02M47/027 ,  F02M45/083 ,  F02B3/06

    摘要： An accumulator fuel injection apparatus in which a nozzle element is divided into a first nozzle having one end side of said nozzle element and a second nozzle having the other end side of the nozzle element. The accumulator fuel injection apparatus comprises a stopper for setting a maximum movement position of the first nozzle toward the second nozzle, a second pressure control chamber communicating with a first pressure control chamber and forming a predetermined space or interval through which the first nozzle and the second nozzle are spaced away from each other under a condition that the first nozzle is arranged at the maximum movement position, and delay apparatus for delaying reduction of pressure within the first pressure control chamber due to the fact that fluid flows into a low-pressure chamber from the first pressure control chamber upon communication of the first pressure control chamber and the low-pressure chamber with each other. It is possible to easily perform operation of setting an amount of pre-lift of the nozzle needle which decides an injection rate, and operation of assembling constitutional elements thereof.

    摘要翻译： 一种蓄能器燃料喷射装置，其中喷嘴元件被分成具有所述喷嘴元件的一端侧的第一喷嘴和具有所述喷嘴元件的另一端侧的第二喷嘴。 蓄能器燃料喷射装置包括用于将第一喷嘴朝向第二喷嘴的最大运动位置设置的止动件，与第一压力控制室连通并形成预定空间或间隔的第二压力控制室，第一喷嘴和第二喷嘴 喷嘴在第一喷嘴布置在最大移动位置的条件下彼此间隔开;以及延迟装置，用于延迟第一压力控制室内的压力降低，这是由于流体从低压室流入低压室 所述第一压力控制室在所述第一压力控制室和所述低压室彼此连通时。 能够容易地进行决定喷射速度的喷嘴针的预升程量的设定以及组合构成要素的动作。